Dopamine dependency of oscillations between subthalamic nucleus and pallidum in Parkinson's disease [PDF]
The extent of synchronization within and between the nuclei of the basal ganglia is unknown in Parkinson's disease. The question is an important one because synchronization will increase postsynaptic efficacy at subsequent projection targets.
Peter Brown +11 more
core +1 more source
The role of the subthalamic nucleus in cognition [PDF]
Because the complex functions of the basal ganglia have been increasingly studied over the past several decades, the understanding of the role of the subthalamic nucleus (STN) in motor and cognitive functions has evolved. The traditional role in motor function ascribed to the STN, based on its involvement in the cortico-striato-thalamo-cortical motor ...
David B, Weintraub, Kareem A, Zaghloul
openaire +2 more sources
Subthalamic–pallidal interactions are critical in determining normal and abnormal functioning of the basal ganglia [PDF]
The subthalamic nucleus (STN) and external globus pallidus (GP) form a recurrent excitatory–inhibitory interaction within the basal ganglia. Through a computational model of these interactions we show that, under the influence of appropriate external ...
Willshaw, D. +3 more
core +1 more source
Disrupted dopamine transmission and the emergence of exaggerated beta oscillations in subthalamic nucleus and cerebral cortex [PDF]
In the subthalamic nucleus (STN) of Parkinson’s disease (PD) patients, a pronounced synchronization of oscillatory activity at beta frequencies (15–30 Hz) accompanies movement difficulties.
Sharott, A +6 more
core +1 more source
The contribution of the subthalamic nucleus to executive functions in rat [PDF]
Lesions of the subthalamic nucleus (STN) alleviate the cardinal signs of idiopathic as well as MPTP-induced Parkinson’s disease in primates. For this reason, the STN is a target for clinical treatment of Parkinson’s disease using deep brain ...
Xia, Shuang
core +2 more sources
Dorsal subthalamic nucleus targeting in deep brain stimulation:microelectrode recording versus 7-Tesla connectivity [PDF]
Connectivity-derived 7-Tesla MRI segmentation and intraoperative microelectrode recording can both assist subthalamic nucleus targeting for deep brain stimulation in Parkinson's disease. It remains unclear whether deep brain stimulation electrodes placed
Potters, Wouter V. +22 more
core +1 more source
Parkinsonian beta oscillations in the external globus pallidus and their relationship with subthalamic nucleus activity [PDF]
Inappropriately synchronized beta (β) oscillations (15–30 Hz) in the subthalamic nucleus (STN) accompany movement difficulties in idiopathic Parkinson's disease (PD).
Bolam, JP +11 more
core +1 more source
Role of the subthalamic nucleus in motor control. [PDF]
González-Escamilla G +2 more
europepmc +3 more sources
We aimed to explore the effects of bilateral subthalamic nucleus stimulation and levodopa on cardiovascular autonomic function in Parkinson’s disease.
Kai Li +6 more
doaj +1 more source
Dynamic modulation of subthalamic nucleus activity facilitates adaptive behavior.
Adapting actions to changing goals and environments is central to intelligent behavior. There is evidence that the basal ganglia play a crucial role in reinforcing or adapting actions depending on their outcome.
Damian M Herz +10 more
doaj +1 more source

