Results 11 to 20 of about 335,108 (249)

Analysis of patient-specific stimulation with segmented leads in the subthalamic nucleus. [PDF]

PLoS ONE, 2019
ObjectiveSegmented deep brain stimulation leads in the subthalamic nucleus have shown to increase therapeutic window using directional stimulation. However, it is not fully understood how these segmented leads with reduced electrode size modify the ...
T A Khoa Nguyen, Milan Djilas, Andreas Nowacki, André Mercanzini, Michael Schüpbach, Philipp Renaud, Claudio Pollo   +6 more
doaj   +4 more sources

Subthalamic Nucleus: Neuroanatomical Review

Brazilian Neurosurgery, 2017
Discovered in 1865 by Jules Bernard Luys, the subthalamic nucleus is a set of small nuclei located in the diencephalon, inferior to the thalamus and superior to the substantia nigra, that can be visualized in a posterior coronal section.
Marcelo José Silva de Magalhães, Claudiojanes dos Reis, Juliana Rabelo da Silva Sousa, Victória Souza Marques, Tayná Cardoso Gonçalves, Iara Cristina Vieira Ribeiro, Leide Daiana Silveira Cardoso, Victor Caribé Crosland Guimarães, Frederico Gustavo de Souza Marques, Sarah Dias Pereira   +9 more
doaj   +2 more sources

Architecture of the subthalamic nucleus

Communications Biology
The subthalamic nucleus (STN) is a major neuromodulation target for the alleviation of neurological and neuropsychiatric symptoms using deep brain stimulation (DBS). STN-DBS is today applied as treatment in Parkinson´s disease, dystonia, essential tremor,
Asheeta A. Prasad, Åsa Wallén-Mackenzie   +1 more
doaj   +4 more sources

Unraveling the enigmatic role of the subthalamic nucleus

eLife
Subpopulations of neurons in the subthalamic nucleus have distinct activity patterns that relate to the three hypotheses of the Drift Diffusion Model.
Qianli Yang
doaj   +3 more sources

Topography and distribution of adenosine A2A and dopamine D2 receptors in the human Subthalamic Nucleus

Frontiers in Neuroscience, 2022
The human Subthalamic Nucleus (STh) is a diencephalic lens-shaped structure located ventrally to the thalamus and functionally implicated in the basal ganglia circuits.
Aron Emmi, Aron Emmi, Aron Emmi, Angelo Antonini, Angelo Antonini, Michele Sandre, Michele Sandre, Andrea Baldo, Martina Contran, Veronica Macchi, Veronica Macchi, Diego Guidolin, Andrea Porzionato, Andrea Porzionato, Raffaele De Caro, Raffaele De Caro   +15 more
doaj   +1 more source

Disrupted dopamine transmission and the emergence of exaggerated beta oscillations in subthalamic nucleus and cerebral cortex [PDF]

, 2008
In the subthalamic nucleus (STN) of Parkinson’s disease (PD) patients, a pronounced synchronization of oscillatory activity at beta frequencies (15–30 Hz) accompanies movement difficulties.
Sharott, A, Brown, Peter, Bolam, JP, Pogosyan, A, Magill, PJ, Brown, P, Mallet, N, Csicsvari, J   +7 more
core   +1 more source

The contribution of the subthalamic nucleus to executive functions in rat [PDF]

, 2014
Lesions of the subthalamic nucleus (STN) alleviate the cardinal signs of idiopathic as well as MPTP-induced Parkinson’s disease in primates. For this reason, the STN is a target for clinical treatment of Parkinson’s disease using deep brain ...
Xia, Shuang
core   +2 more sources

The subthalamic nucleus becomes a generator of bursts in the dopamine-depleted state. Its high frequency stimulation dramatically weakens transmission to the globus pallidus

Frontiers in Systems Neuroscience, 2011
Excessive burst firing in the dopamine-depleted basal ganglia correlates with severe motor symptoms of Parkinson’s disease that are attenuated by high frequency electrical stimulation of the subthalamic nucleus.
Rachida eAmmari, Rachida eAmmari, Bernard eBioulac, Liliana eGarcia, Constance eHammond   +4 more
doaj   +1 more source

Dopamine dependency of oscillations between subthalamic nucleus and pallidum in Parkinson's disease [PDF]

, 2001
The extent of synchronization within and between the nuclei of the basal ganglia is unknown in Parkinson's disease. The question is an important one because synchronization will increase postsynaptic efficacy at subsequent projection targets.
Peter Brown, Vincenzo Di Lazzaro, Oliviero, A, Insola, A, Brown, Peter, Antonio Oliviero, Di Lazzaro, V, Mazzone, P, Brown, P, Pietro Tonali, Tonali, P, Paolo Mazzone, Angelo Insola   +12 more
core   +1 more source

Targeting the Subthalamic Nucleus

Stereotactic and Functional Neurosurgery, 2001
The small size and surrounding neuronal structures and fibre tracts make the STN a difficult stereotactic target. In this article we present the technique used by us to target the STN. Our combined experience from two centres comprises 18 lesions and 27 stimulator implants in the STN.
Aziz, T, Nandi, D, Parkin, S, Liu, X, Giladi, N, Bain, P, Gregory, R, Joint, C, Scott, R, Stein, J   +9 more
openaire   +3 more sources