Analysis of patient-specific stimulation with segmented leads in the subthalamic nucleus. [PDF]
PLoS ONE, 2019 ObjectiveSegmented deep brain stimulation leads in the subthalamic nucleus have shown to increase therapeutic window using directional stimulation. However, it is not fully understood how these segmented leads with reduced electrode size modify the ...
T A Khoa Nguyen +6 more
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Subthalamic Nucleus: Neuroanatomical Review
Brazilian Neurosurgery, 2017 Discovered in 1865 by Jules Bernard Luys, the subthalamic nucleus is a set of small nuclei located in the diencephalon, inferior to the thalamus and superior to the substantia nigra, that can be visualized in a posterior coronal section.
Marcelo José Silva de Magalhães +9 more
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Architecture of the subthalamic nucleus
Communications BiologyThe subthalamic nucleus (STN) is a major neuromodulation target for the alleviation of neurological and neuropsychiatric symptoms using deep brain stimulation (DBS). STN-DBS is today applied as treatment in Parkinson´s disease, dystonia, essential tremor,
Asheeta A. Prasad +1 more
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Unraveling the enigmatic role of the subthalamic nucleus
eLifeSubpopulations of neurons in the subthalamic nucleus have distinct activity patterns that relate to the three hypotheses of the Drift Diffusion Model.
Qianli Yang
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Hardware Sophistications in Subthalamic Nucleus Deep Brain Stimulation for Parkinson's Disease; Is the Juice Worth the Squeeze? [PDF]
Mov Disord Clin PractAbstract Background New sophisticated deep brain stimulation (DBS) systems enabling steering of current and aiming at improving further motor outcome and decreasing side effects have virtually replaced old omnidirectional systems, despite being more labor‐intensive and expensive.
Hariz M, Blomstedt P.
europepmc +2 more sources
Are there three Subdivisions in the primate Subthalamic Nucleus? [PDF]
Frontiers in Neuroanatomy, 2012 The prevailing academic opinion holds that the subthalamic nucleus (STN) consists of three parts, each anatomically distinct and selectively associated with cognitive, emotional, or motor functioning.
Max C Keuken +7 more
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Targeting the Subthalamic Nucleus in MEGDEL Syndrome: A Case Report of a Clinically Effective Intervention for Debilitating Lingual Dyskinesia and Dystonia. [PDF]
Mov Disord Clin PractMovement Disorders Clinical Practice, EarlyView.
Köberle P +9 more
europepmc +2 more sources
A Species-Dependent Spatial Patterning of FOXP1 and nNOS Protein Expression in the Adult Mammalian Subthalamic Nucleus. [PDF]
J Comp NeurolFOXP1+ and nNOS+ neurons constitute distinct neuronal populations in the adult subthalamic nucleus, with spatial segregation in rodents but extensive intermixing in humans. The human STN also shows an expanded nNOS+ population and increased FOXP1+/nNOS+ colocalization, highlighting species‐specific differences in STN organization.
Medenica T +3 more
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The subthalamic nucleus, oscillations, and conflict [PDF]
Movement Disorders, 2015 AbstractThe subthalamic nucleus (STN), which is currently the most common target for deep brain stimulation (DBS) for Parkinson's disease (PD), has received increased attention over the past few years for the roles it may play in functions beyond simple motor control.
Baltazar, Zavala +2 more
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Targeting the Subthalamic Nucleus
Stereotactic and Functional Neurosurgery, 2001 The small size and surrounding neuronal structures and fibre tracts make the STN a difficult stereotactic target. In this article we present the technique used by us to target the STN. Our combined experience from two centres comprises 18 lesions and 27 stimulator implants in the STN.
Aziz, T +9 more
openaire +3 more sources