Results 41 to 50 of about 488,438 (323)
Connectivity and Dynamics Underlying Synaptic Control of the Subthalamic Nucleus
Journal of Neuroscience, 2019 Adaptive motor control critically depends on the interconnected nuclei of the basal ganglia in the CNS. A pivotal element of the basal ganglia is the subthalamic nucleus (STN), which serves as a therapeutic target for deep brain stimulation (DBS) in ...
L. A. Steiner +5 more
semanticscholar +1 more source
Analysis of patient-specific stimulation with segmented leads in the subthalamic nucleus.
PLoS ONE, 2019 ObjectiveSegmented deep brain stimulation leads in the subthalamic nucleus have shown to increase therapeutic window using directional stimulation. However, it is not fully understood how these segmented leads with reduced electrode size modify the ...
T A Khoa Nguyen +6 more
doaj +1 more source
Efficient Micro-electrode Recording Modeling using a Filtered Point Process [PDF]
TNSRE-2014-00276.R1, 2013 In this paper we present an efficient model of the neuronal potentials recorded by a deep brain stimulation microelectrode (DBS MER) in the subthalamic nucleus. It is shown that a computationally efficient filtered point process consisting of 10,000 neurons, including extracellular filtering closely matches recordings from 13 Parkinson's disease ...
arxiv +1 more source
Subthalamic Nucleus Deep Brain Stimulation Evokes Resonant Neural Activity
Annals of Neurology, 2018 Deep brain stimulation (DBS) is a rapidly expanding treatment for neurological and psychiatric conditions; however, a target‐specific biomarker is required to optimize therapy.
N. Sinclair +7 more
semanticscholar +1 more source
PLoS ONE, 2018 Anatomical atlases have been developed to improve the targeting of basal ganglia in deep brain stimulation. However, the sole anatomy cannot predict the functional outcome of this surgery.
Claire Haegelen +7 more
doaj +1 more source
Dynamic modulation of subthalamic nucleus activity facilitates adaptive behavior.
PLoS Biology, 2023 Adapting actions to changing goals and environments is central to intelligent behavior. There is evidence that the basal ganglia play a crucial role in reinforcing or adapting actions depending on their outcome.
Damian M Herz +10 more
doaj +1 more source
Modeling effect of GABAergic current in a basal ganglia computational model [PDF]
Cogn. Neurodyn. 6(4), 333-341 (2012), 2013 Electrical high frequency stimulation (HFS) of deep brain regions is a method shown to be clinically effective in different types of movement and neurological disorders. In order to shed light on its mode of action a computational model of the basal ganglia network coupled the HFS as injection current into the cells of the subthalamic nucleus (STN ...
arxiv +1 more source
Pallidal versus subthalamic nucleus deep brain stimulation for levodopa‐induced dyskinesia
Annals of Clinical and Translational Neurology, 2019 To compare the efficacy of subthalamic nucleus (STN) and globus pallidus internus (GPi) deep brain stimulation (DBS) on reducing levodopa‐induced dyskinesia (LID) in Parkinson’s disease, and to explore the potential underlying mechanisms.
Shiying Fan +11 more
semanticscholar +1 more source
Is Deep Brain Stimulation a viable treatment for substance-related addiction? [PDF]
Romanian Journal of Neurology, 2019 For the ability to modulate the activity of dysregulated networks Deep Brain Stimulation (DBS) of areas involved in reward system and motivational states may have a potential application in addiction despite risks associated with its invasiveness.
Giusy Guzzi +3 more
doaj +1 more source
Nomogram for Predicting Depression Improvement after Deep Brain Stimulation for Parkinson’s Disease
Brain Sciences, 2022 Background: Parkinson’s disease is a common neurodegenerative disease, with depression being a common non-motor symptom. Bilateral subthalamic nucleus deep brain stimulation is an effective method for the treatment of Parkinson’s disease.
Bowen Chang +6 more
doaj +1 more source