Dynamic modulation of subthalamic nucleus activity facilitates adaptive behavior.
PLoS Biology, 2023 Adapting actions to changing goals and environments is central to intelligent behavior. There is evidence that the basal ganglia play a crucial role in reinforcing or adapting actions depending on their outcome.
Damian M Herz +10 more
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Development of a novel gripping test for the evaluation of the finger fine motor ability in MPTP-treated monkeys [PDF]
Journal of Integrative Neuroscience, 2020 Assessing the finger fine motor ability is extremely important. However, conventional behavioral tests in monkeys are complicated and costly. We attempted to develop a new task to assess the precise finger grip in Parkinson's disease monkeys based on the
Susumu Kobayashi, Tetsuya Asakawa, Takao Nozaki, Kenji Sugiyama, Tetsuro Sameshima, Kazuhiko Kurozumi
doaj +1 more source
The subcortical cocktail problem; mixed signals from the subthalamic nucleus and substantia nigra.
PLoS ONE, 2015 The subthalamic nucleus and the directly adjacent substantia nigra are small and important structures in the basal ganglia. Functional magnetic resonance imaging studies have shown that the subthalamic nucleus and substantia nigra are selectively ...
Gilles de Hollander +2 more
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Translational Psychiatry, 2022 Patients with psychiatric symptoms, such as depression, anxiety, and visual hallucinations, may be at increased risk for adverse effects following deep brain stimulation of the subthalamic nucleus for Parkinson’s disease, but there have been relatively ...
Ian H. Kratter +7 more
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Neuronal Activity in the Human Subthalamic Nucleus Encodes Decision Conflict during Action Selection [PDF]
, 2012 The subthalamic nucleus (STN), which receives excitatory inputs from the cortex and has direct connections with the inhibitory pathways\ud of the basal ganglia, is well positioned to efficiently mediate action selection.
Baltuch, G. H. +5 more
core +2 more sources
Physical therapy and deep brain stimulation in Parkinson’s Disease: Protocol for a pilot randomized controlled trial [PDF]
, 2018 Background Subthalamic nucleus deep brain stimulation (STN-DBS) reduces tremor, muscle stiffness, and bradykinesia in people with Parkinson’s Disease (PD).
Duncan, Ryan P +4 more
core +2 more sources
Basal ganglia role in learning rewarded actions and executing previously learned choices: Healthy and diseased states [PDF]
, 2020 The basal ganglia (BG) is a collection of nuclei located deep beneath the cerebral cortex that is involved in learning and selection of rewarded actions. Here, we analyzed BG mechanisms that enable these functions.
Atwood, Brady +2 more
core +1 more source
Analysis of patient-specific stimulation with segmented leads in the subthalamic nucleus.
PLoS ONE, 2019 ObjectiveSegmented deep brain stimulation leads in the subthalamic nucleus have shown to increase therapeutic window using directional stimulation. However, it is not fully understood how these segmented leads with reduced electrode size modify the ...
T A Khoa Nguyen +6 more
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PLoS ONE, 2018 Anatomical atlases have been developed to improve the targeting of basal ganglia in deep brain stimulation. However, the sole anatomy cannot predict the functional outcome of this surgery.
Claire Haegelen +7 more
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Striatal cholinergic interneurons generate beta and gamma oscillations in the corticostriatal circuit and produce motor deficits [PDF]
, 2016 Cortico-basal ganglia-thalamic (CBT) neural circuits are critical modulators of cognitive and motor function. When compromised, these circuits contribute to neurological and psychiatric disorders, such as Parkinson's disease (PD).
Bucklin, Mark +5 more
core +1 more source