Results 41 to 50 of about 490,973 (323)

Dexmedetomidine depresses neuronal activity in the subthalamic nucleus during deep brain stimulation electrode implantation surgery

BJA Open, 2022
Background: Micro-electrode recordings are often necessary during electrode implantation for deep brain stimulation of the subthalamic nucleus. Dexmedetomidine may be a useful sedative for these procedures, but there is limited information regarding its ...
Corey Amlong, Deborah Rusy, Robert D. Sanders, Wendell Lake, Aeyal Raz   +4 more
doaj  

Modulation of Beta Bursts in the Subthalamic Nucleus Predicts Motor Performance

Journal of Neuroscience, 2018
Considerable evidence suggests a role of beta-band oscillations in voluntary movements. However, most of the studies linking beta power to motor performance are based on data averaged across trials that ignore the fast dynamics of oscillatory activity ...
F. Torrecillos, G. Tinkhauser, P. Fischer, A. Green, T. Aziz, T. Foltynie, P. Limousin, L. Zrinzo, K. Ashkan, P. Brown, H. Tan   +10 more
semanticscholar   +1 more source

Optogenetics and deep brain stimulation neurotechnologies [PDF]

, 2015
Brain neural network is composed of densely packed, intricately wired neurons whose activity patterns ultimately give rise to every behavior, thought, or emotion that we experience. Over the past decade, a novel neurotechnique, optogenetics that combines
A Berndt, A Berndt, A Priori, AA Kuhn, AA Kuhn, AS Chuong, B Sauer, B Wingeier, BY Chow, BY Chow, C Bamann, D Luo, D Oesterhelt, D Oesterhelt, D Williams, ES Boyden, EY Uc, F Zhang, F Zhang, G Foffani, G Miesenbock, G Nagel, J Cavanaugh, J Mobley, J Volkmann, J Wells, J Wietek, JG Bernstein, JG Bernstein, JG Bernstein, JL Spudich, JL Spudich, JO Dostrovsky, JZ Tsien, L Bekar, L Madisen, LA Gunaydin, M Weinberger, M Weinberger, MC Rodriguez-Oroz, MJ Lehmkuhle, ML Welter, MM Doroudchi, O Yizhar, P Brown, P Silberstein, R Levy, R Levy, R Levy, R Waehler, S Zhao, TW Chen, VC Anderson, X Han, X Han, X Han, X Han, X Han, X Liu   +58 more
core   +2 more sources

Analysis of patient-specific stimulation with segmented leads in the subthalamic nucleus.

PLoS ONE, 2019
ObjectiveSegmented deep brain stimulation leads in the subthalamic nucleus have shown to increase therapeutic window using directional stimulation. However, it is not fully understood how these segmented leads with reduced electrode size modify the ...
T A Khoa Nguyen, Milan Djilas, Andreas Nowacki, André Mercanzini, Michael Schüpbach, Philipp Renaud, Claudio Pollo   +6 more
doaj   +1 more source

Dynamic modulation of subthalamic nucleus activity facilitates adaptive behavior.

PLoS Biology, 2023
Adapting actions to changing goals and environments is central to intelligent behavior. There is evidence that the basal ganglia play a crucial role in reinforcing or adapting actions depending on their outcome.
Damian M Herz, Manuel Bange, Gabriel Gonzalez-Escamilla, Miriam Auer, Muthuraman Muthuraman, Martin Glaser, Rafal Bogacz, Alek Pogosyan, Huiling Tan, Sergiu Groppa, Peter Brown   +10 more
doaj   +1 more source

Connectivity and Dynamics Underlying Synaptic Control of the Subthalamic Nucleus

Journal of Neuroscience, 2019
Adaptive motor control critically depends on the interconnected nuclei of the basal ganglia in the CNS. A pivotal element of the basal ganglia is the subthalamic nucleus (STN), which serves as a therapeutic target for deep brain stimulation (DBS) in ...
L. Steiner, F. J. Barreda Tomás, H. Planert, H. Alle, I. Vida, Jörg R. P. Geiger   +5 more
semanticscholar   +1 more source

Informed consent decision-making in deep brain stimulation [PDF]

, 2018
Deep brain stimulation (DBS) has proved useful for several movement disorders (Parkinson’s disease, essential tremor, dystonia), in which first and/or second line pharmacological treatments were inefficacious.
Appelbaum, Bell, Berg, Gilbert, Grisso, Jahanshahi, Mehdorn   +6 more
core   +2 more sources

Subthalamic Nucleus Deep Brain Stimulation Evokes Resonant Neural Activity

Annals of Neurology, 2018
Deep brain stimulation (DBS) is a rapidly expanding treatment for neurological and psychiatric conditions; however, a target‐specific biomarker is required to optimize therapy.
N. Sinclair, Hugh J. McDermott, K. Bulluss, J. Fallon, T. Perera, San San Xu, P. Brown, W. Thevathasan   +7 more
semanticscholar   +1 more source

Functional atlases for analysis of motor and neuropsychological outcomes after medial globus pallidus and subthalamic stimulation.

PLoS ONE, 2018
Anatomical atlases have been developed to improve the targeting of basal ganglia in deep brain stimulation. However, the sole anatomy cannot predict the functional outcome of this surgery.
Claire Haegelen, Clément Baumgarten, Jean-François Houvenaghel, Yulong Zhao, Julie Péron, Sophie Drapier, Pierre Jannin, Xavier Morandi   +7 more
doaj   +1 more source

Pallidal versus subthalamic nucleus deep brain stimulation for levodopa‐induced dyskinesia

Annals of Clinical and Translational Neurology, 2019
To compare the efficacy of subthalamic nucleus (STN) and globus pallidus internus (GPi) deep brain stimulation (DBS) on reducing levodopa‐induced dyskinesia (LID) in Parkinson’s disease, and to explore the potential underlying mechanisms.
Shiying Fan, Kailiang Wang, Wei Hu, R. Eisinger, Alexander Han, C. Han, Qiao Wang, Shimabukuro Michitomo, Jian-Guo Zhang, Feng Wang, A. Ramirez-Zamora, F. Meng   +11 more
semanticscholar   +1 more source