Results 81 to 90 of about 490,973 (323)
Genetics‐Based Targeting Strategies for Precise Neuromodulation
Advanced Science, EarlyView.In this Review, the fundamental principles and implementation protocols of genetics‐based precision neuromodulation are first introduced. Then, wireless and low‐invasive strategies based on nano‐transducing materials are highlighted, along with a dissection and analysis of the strengths and weaknesses of representative studies.
Yuyuan He +11 more
wiley +1 more source
Frontiers in Human Neuroscience, 2018 Objective: Magnetic resonance imaging fusion techniques guided by frame-based stereotactic computed tomography and microelectrode recordings are widely used to target the subthalamic nucleus. However, MRI is not always available.
Po-Hsun Tu +10 more
doaj +1 more source
Selective stimulation of the subthalamic nucleus [PDF]
, 2013 Parkinson's disease (PD) is the second most common neurodegenerative disorder. In 2008, about 30.000 PD patients were registered at hospitals in the Netherlands. The number of PD patients is expected to increase by 47% from 2005 to 2025. PD is characterized by several motor related symptoms including tremor, bradykinesia, i.e.
openaire +3 more sources
Neural electrodes for brain‐computer interface system: From rigid to soft
BMEMat, EarlyView.Here, we review the development trends of neural electrodes in BCI. This paper highlights the critical role of electrodes in BCI systems, analyzes the limitations of rigid electrodes, and introduces various flexible electrodes. Furthermore, we discuss application scenarios and prospects of BCI electrode technology, aiming to provide valuable references
Dan Yang +7 more
wiley +1 more source
Striatal cholinergic interneurons generate beta and gamma oscillations in the corticostriatal circuit and produce motor deficits [PDF]
, 2016 Cortico-basal ganglia-thalamic (CBT) neural circuits are critical modulators of cognitive and motor function. When compromised, these circuits contribute to neurological and psychiatric disorders, such as Parkinson's disease (PD).
Bucklin, Mark +5 more
core +1 more source
Parkinson's Disease, 2020 Background. Treatment of freezing of gait (FOG) is always challenging because of its unpredictable nature and multifactorial physiopathology. Intestinal levodopa infusion has been proposed in recent years as a valuable option for its improvement.
Belén González-Herrero +4 more
doaj +1 more source
Subthalamic nucleus high-frequency stimulation restores altered electrophysiological properties of cortical neurons in parkinsonian rat. [PDF]
PLoS ONE, 2013 Electrophysiological recordings performed in parkinsonian patients and animal models have confirmed the occurrence of alterations in firing rate and pattern of basal ganglia neurons, but the outcome of these changes in thalamo-cortical networks remains ...
Bertrand Degos +3 more
doaj +1 more source
Annals of Neurology, 2017 Deep brain stimulation (DBS) of the subthalamic nucleus (STN) is a highly effective symptomatic therapy for motor deficits in Parkinson's disease (PD).
T. Musacchio +6 more
semanticscholar +1 more source
ChemMedChem, EarlyView.Dysregulated proteolysis mediated by kallikrein‐related peptidases (KLKs) and iron overload are involved in the progression of neurodegenerative diseases. Deferasirox, an clinically‐approved iron chelator, and its newly synthesized derivatives have been identified as inhibitors of major central nervous system KLKs with low cytotoxicity and effective ...
Rilès Boumali +11 more
wiley +1 more source
Measuring activity of the subthalamic nucleus in acute slices using multi electrode arrays [PDF]
, 2009 The symptoms of Parkinson’s disease (a.o.: tremor, rigidity) can be suppressed by electrical stimulation of the basal ganglia. The most common target nucleus of this so called Deep Brain Stimulation (DBS) is the subthalamic nucleus (STN).
Heida, T., Stegenga, J.
core +1 more source