Results 91 to 100 of about 38,228 (259)

In Parkinson's disease STN stimulation enhances responsiveness of movement initiation speed to high reward value [PDF]

, 2016
Objective: The subthalamic nucleus (STN) is part of the motor, associative, and limbic cortico-striatal circuits through which it can influence a range of behaviours, with preclinical and clinical evidence suggesting that the STN is involved in ...
Higgins, A, Jahanshahi, M, Kojovic, M
core   +1 more source

Local Field Potential‐Based Programming: A Proof‐of‐Concept Pilot Study

Neuromodulation: Technology at the Neural Interface, EarlyView., 2021
Abstract Objectives Programming deep brain stimulation (DBS) is still based on a trial‐and‐error approach, often becoming a time‐consuming process for both treating physicians and patients. Several strategies have been proposed to streamline DBS programming, most of which are preliminary and mainly address Parkinson's disease, a condition readily ...
Alfonso Fasano, Carolina Gorodetsky, Darcia Paul, Jürgen Germann, Aaron Loh, Han Yan, Peter L. Carlen, Sara Breitbart, Andres M. Lozano, George M. Ibrahim, Suneil K. Kalia   +10 more
wiley   +1 more source

Subcortical correlates of consciousness with human single neuron recordings

eLife
Subcortical brain structures such as the subthalamic nucleus or the thalamus are involved in regulating motor and cognitive behavior. However, their contribution to perceptual consciousness remains unclear, due to the inherent difficulties of recording ...
Michael Pereira, Nathan Faivre, Fosco Bernasconi, Nicholas Brandmeir, Jacob E Suffridge, Kaylee Tran, Shuo Wang, Victor Finomore, Peter Konrad, Ali Rezai, Olaf Blanke   +10 more
doaj   +1 more source

Acute hemiballismus in the absence of subthalamic nucleus lesion

MGM Journal of Medical Sciences, 2020
A 68-year-old male, known hypertensive on irregular medication presented with sudden onset of involuntary movements of the left upper limb, in the form of severely violent, arrhythmic, and flinging large amplitude movements for 2 days, suggestive of ...
Shreya Gudi, Tushar Kanti Biswas, Rucha Sane   +2 more
doaj   +1 more source

Subthalamic nucleus stabilizes movements by reducing neural spike variability in monkey basal ganglia

Nature Communications, 2022
Chemogenetic inactivation of the subthalamic nucleus in monkeys increases spike train variability in the pallidum and prolongs movement time, suggesting its role in stabilizing pallidal spike trains to achieve stable motor control.
Taku Hasegawa, Satomi Chiken, Kenta Kobayashi, Atsushi Nambu   +3 more
doaj   +1 more source

Pallidal origin of GABA release within the substantia nigra pars reticulata during high-frequency stimulation of the subthalamic nucleus [PDF]

, 2005
High-frequency stimulation of the subthalamic nucleus (HFS-STN) is an effective treatment for alleviating the motor symptoms of parkinsonian patients. However, the neurochemical basis of its effects remains unknown.
Carcenac, Carole, Poupard, Annie, Savasta, Marc, Windels, François   +3 more
core   +3 more sources

The Intraoperative Microlesion Effect Positively Correlates With the Short‐Term Clinical Effect of Deep Brain Stimulation in Parkinson's Disease

Neuromodulation: Technology at the Neural Interface, EarlyView., 2021
Abstract Objective During the surgical procedure of deep brain stimulation (DBS), insertion of an electrode in the subthalamic nucleus (STN) frequently causes a temporary improvement of motor symptoms, known as the microlesion effect (MLE). The objective of this study was to determine the correlation between the intraoperative MLE and the clinical ...
Stèfan F. Lange, Naomi I. Kremer, Teus van Laar, Fiete Lange, T. Elien Steendam‐Oldekamp, D. L. Marinus Oterdoom, Anthony R. Absalom, J. Marc C. van Dijk, Gea Drost   +8 more
wiley   +1 more source

Molecular glucose imaging reveals functional brain reconfiguration by subthalamic deep brain stimulation in Parkinsonian rats

Translational Neurodegeneration
Background In order to elucidate the neuromodulatory mechanisms underlying therapeutic subthalamic deep brain stimulation (DBS), we here reverse-translate a methodological pipeline that integrates neurostimulation effect parameterization and molecular ...
Jiazhi Chen, Ningfei Li, Muthuraman Muthuraman, Nengxing Liang, Jens Volkmann, Takahiro Higuchi, Chi Wang Ip   +6 more
doaj   +1 more source

Imaging the Centromedian Thalamic Nucleus Using Quantitative Susceptibility Mapping. [PDF]

, 2019
The centromedian (CM) nucleus is an intralaminar thalamic nucleus that is considered as a potentially effective target of deep brain stimulation (DBS) and ablative surgeries for the treatment of multiple neurological and psychiatric disorders.
Gutierrez, Lorenzo, Li, Dianyou, Li, Jun, Li, Yufei, Liu, Chunlei, Sun, Bomin, Wei, Hongjiang, Wu, Yiwen, Xu, Wenying, Zhang, Chencheng   +9 more
core  

Inference with interference between units in an fMRI experiment of motor inhibition

, 2017
An experimental unit is an opportunity to randomly apply or withhold a treatment. There is interference between units if the application of the treatment to one unit may also affect other units.
Aron A. R., Chiang-Shan R. Li, Cochran W. G., Conover W. J., Cox D. R., David O., Deshpande J. V., Duann J. R., Dylan S. Small, Fisher R. A., Forstmann B. U., Friston K. J., Friston K. J., Hoeffding W., Hudgens M. G., Lehmann E. L., Lehmann E. L., Li C. S., Lindquist M. A., Lindquist M. A., Lindquist M. A., Neyman J., Neyman J., Neyman J., Orban J., Paul R. Rosenbaum, Puri M. L., Rosenbaum P. R., Rosenbaum P. R., Rosenbaum P. R., Rosenbaum P. R., Rosenbaum P. R., Rubin D. B., Salsburg D. S., Simmonds D. J., Sobel M. E., Stephenson W. R., Stephenson W. R., Tukey J. W., Weiss L., Welch B. L., Xi Luo   +41 more
core   +1 more source