Results 101 to 110 of about 351,721 (248)

Molecular glucose imaging reveals functional brain reconfiguration by subthalamic deep brain stimulation in Parkinsonian rats

Translational Neurodegeneration
Background In order to elucidate the neuromodulatory mechanisms underlying therapeutic subthalamic deep brain stimulation (DBS), we here reverse-translate a methodological pipeline that integrates neurostimulation effect parameterization and molecular ...
Jiazhi Chen, Ningfei Li, Muthuraman Muthuraman, Nengxing Liang, Jens Volkmann, Takahiro Higuchi, Chi Wang Ip   +6 more
doaj   +1 more source

Disease Duration Differentiates Freezing of Gait Response to Subthalamic and Nigral Stimulation for Parkinson's Disease in an Exploratory Multicenter Controlled Trial

Movement Disorders Clinical Practice, EarlyView.
Abstract Background Freezing of gait (FoG) belongs to most pressing unmet symptoms in the treatment of Parkinson's disease. Objectives To explore whether combined subthalamic and nigral (STN + SNr) deep brain stimulation improves FoG compared with optimized STN stimulation alone; to identify clinical variables associated with therapeutic response ...
Daniel Weiss, Idil Cebi, Marion Schütt, Imma Fischer, Lukas Pavelka, Pierre Kolber, Monika Pötter‐Nerger, Wolfgang Hamel, Andrea A. Kühn, Christian J. Hartmann, Kai Bötzel, Thomas Köglsperger, Michael T. Barbe, Zacharias Kohl, Steffen Paschen, Markus A. Hobert, Sergiu Groppa, Tobias Warnecke, Inga Claus, Rejko Krüger, Alireza Gharabaghi, For the Multicenter STN+SNr Study Group, Christian Stallinger, Frank Hertel, Daniel Kroneberg, Carsten Buhmann, Alessandro Gulberti, Beate Schönewald, Verena Zentsch, Verle Visser‐Vandewalle   +29 more
wiley   +1 more source

Deep Brain Stimulation of the Subthalamic Nucleus in Parkinson’s Disease: A Meta-Analysis of Mood Effects

, 2021
Deep Brain Stimulation of the Subthalamic Nucleus in Parkinson’s Disease: A Meta-Analysis of Mood ...
Jane McGillivray (13083930), Linda Byrne (13081350), David Skvarc (13067847), Michael Berk (13060851), T Cartmill (9849020), R Bittar (13358481)   +5 more
core  

Effects of aging on nitrergic neurons in human striatum and subthalamic nucleus

Arquivos de Neuro-Psiquiatria, 2015
Nitric oxide (NO) is a major neurotransmitter associated with motor control in basal ganglia. Movement disorders, as essential tremor and Parkinson’s disease, are more prevalent on aged individuals.
Bruno Lopes dos Santos-Lobato, Elaine Aparecida Del-Bel, José Eymard Homem Pittella, Vitor Tumas   +3 more
doaj   +1 more source

Continuous Subcutaneous Apomorphine as a Temporary Bridging Therapy for Dopamine Dysregulation Syndrome in Patients with Deep Brain Stimulation

Movement Disorders Clinical Practice, EarlyView.
Abstract Background Dopamine dysregulation syndrome (DDS) is a challenging complication of dopaminergic therapy in Parkinson's disease and can persist despite subthalamic deep brain stimulation (STN‐DBS). We evaluated a temporary bridging concept in which oral dopaminergic medication was replaced by continuous subcutaneous apomorphine infusion while ...
Tobias Binder, Johannes Hartig, Lennart Sitzmann, Chi Wang Ip, Philipp Capetian, Florian Lange, Martin Reich, Christine Daniels, Jens Volkmann   +8 more
wiley   +1 more source

Subthalamic nucleus correlates of force adaptation

, 2023
Dataset available at: https://data.mrc.ox.ac.uk/data-set/subthalamic-nucleus-correlates-force-adaptation This code analyses behavioural data from a group of 16 Parkinson patients and 15 healthy control participants performing an action adaptation tasks ...

core   +1 more source

Prefrontal-Subthalamic Hyperdirect Pathway Modulates Movement Inhibition in Humans [PDF]

, 2020
The ability to dynamically change motor outputs, such as stopping an initiated response, is an important aspect of human behavior. A hyperdirect pathway between the inferior frontal gyrus and subthalamic nucleus is hypothesized to mediate movement ...
Miller, Andrew M, Chen, Witney, Larson, Paul S, Starr, Philip A, Leibbrand, Michael, Little, Simon J, de Hemptinne, Coralie, Lim, Daniel A   +7 more
core   +1 more source

Quantifying local field potential dynamics with amplitude and frequency stability between ON and OFF medication and stimulation in Parkinson's disease

Neurobiology of Disease
Neural oscillations are critical to understanding the synchronisation of neural activities and their relevance to neurological disorders. For instance, the amplitude of beta oscillations in the subthalamic nucleus has gained extensive attention, as it ...
Xuanjun Guo, Shenghong He, Xinyi Geng, Pan Yao, Christoph Wiest, Yingnan Nie, Huiling Tan, Shouyan Wang   +7 more
doaj   +1 more source

No Additional Benefit of 185 Hz Versus 130 Hz at Equivalent Energy in Deep Brain Stimulation for Tremor: A Randomized Prospective Clinical Trial

Movement Disorders Clinical Practice, EarlyView.
Abstract Background Deep brain stimulation (DBS) of the ventral intermediate nucleus and posterior subthalamic area (VIM/PSA) in Essential Tremor (ET) and the subthalamic nucleus (STN) in Parkinson's disease (PD) are established treatments for tremor. To achieve maximum tremor control, increasing stimulation frequency beyond 130 Hz is part of clinical ...
Christina van der Linden, Peer Trapp, Till A. Dembek, Charlotte Schedlich‐Teufer, Gregor A. Brandt, Hannah Jergas, Gereon R. Fink, Veerle Visser‐Vandewalle, Michael T. Barbe, Jan Niklas Petry‐Schmelzer   +9 more
wiley   +1 more source

A Gap Analysis of Deep Brain Stimulation for Childhood‐Onset Movement Disorders

Movement Disorders, EarlyView.
Abstract Background Deep brain stimulation (DBS) is an established and increasingly utilized therapy for childhood‐onset movement disorders. However, pediatric DBS poses unique challenges that are not adequately addressed by adult‐derived paradigms. Objective To identify key gaps in the current use of DBS in childhood‐onset movement disorders and to ...
Daniela Munoz‐Chesta, Carolina Gorodetsky, Todd M. Herrington, Angela L. Hewitt, Daniel E. Lumsden, Jennifer O'Malley, Terence Sanger   +6 more
wiley   +1 more source