Results 121 to 130 of about 335,108 (249)

Intervention outcomes of children with non‐degenerative dystonia and associated hyperkinetic movement disorders: A scoping review

Developmental Medicine &Child Neurology, EarlyView.
Abstract Aim To identify the outcomes reported in published studies of intervention approaches used with non‐degenerative childhood hyperkinetic movement disorders, including dystonia, dyskinesia, hypertonia, athetosis, chorea, cerebral palsy, involuntary movement, and kernicterus, and map them to the International Classification of Functioning ...
Hortensia Gimeno, Hannah Scott, Rocio Muñoz Sanchez, Alice Doohan, Deepti Chugh, Adrienne Harvey, Kirsty Stewart, Peter Rosenbaum, Grace Stynes, Khamani Edwards, Katherine Knighting   +10 more
wiley   +1 more source

Deep brain stimulation outcomes and management of childhood‐onset dystonia and associated hyperkinetic movements disorders

Developmental Medicine &Child Neurology, EarlyView.
Abstract Aim To examine longitudinal changes in self‐selected goals and dystonia severity over 1 year, 2 years, and 5 years after deep brain stimulation (DBS) in children and young people (CYP) with dystonia and other hyperkinetic movement disorders, using CYP and caregiver reports.
Sinead Barkey, Laura Ainaga, Eva Maria Navarrete Muñoz, Verity McClelland, Keyoumars Ashkan, Richard Selway, Harutomo Hasegawa, Daniel E Lumsden, Jean‐Pierre Lin, Hortensia Gimeno   +9 more
wiley   +1 more source

Subthalamic nucleus

, 1997
Subthalamic nucleus. Coronal plane.

core  

Subthalamic stimulation causally modulates human voluntary decision-making to stay or go

npj Parkinson's Disease
The voluntary nature of decision-making is fundamental to human behavior. The subthalamic nucleus is important in reactive decision-making, but its role in voluntary decision-making remains unclear.
Yichen Wang, Linbin Wang, Luis Manssuer, Yi-jie Zhao, Qiong Ding, Yixin Pan, Peng Huang, Dianyou Li, Valerie Voon   +8 more
doaj   +1 more source

Synaptic Integration of Functionally Diverse Pallidal Information in the Entopeduncular Nucleus and Subthalamic Nucleus in the Rat

, 1997
To determine the principles of synaptic innervation of neurons in the entopeduncular nucleus and subthalamic nucleus by neurons of functionally distinct regions of the pallidal complex, double anterograde labeling was carried out at both light and ...
J. Paul Bolam, Nick P. Clarke, Mark D. Bevan   +2 more
core   +1 more source

A rapid multi-parametric quantitative MR imaging method to assess Parkinson’s disease: a feasibility study

BMC Medical Imaging
Background MULTIPLEX is a single-scan three-dimensional multi-parametric MRI technique that provides 1 mm isotropic T1-, T2*-, proton density- and susceptibility-weighted images and the corresponding quantitative maps. This study aimed to investigate its
Min Duan, Rongrong Pan, Qing Gao, Xinying Wu, Hai Lin, Jianmin Yuan, Yamei Zhang, Lindong Liu, Youyong Tian, Tong Fu   +9 more
doaj   +1 more source

Subthalamic nucleus stimulation in severe obsessive-compulsive disorder.

, 2008
International audienceBACKGROUND: Severe, refractory obsessive-compulsive disorder (OCD) is a disabling condition. Stimulation of the subthalamic nucleus, a procedure that is already validated for the treatment of movement disorders, has been proposed as
Pelissolo, Antoine, Chaynes, Patrick, Chabardès, Stephan, Arbus, Christophe, Montcel, Sophie Tezenas du, Pollak, Pierre, Chéreau, Isabelle, Magnié-Mauro, Marie-Noële, Bougerol, T., Millet, Bruno, Benabid, Alim-Louis, Devaux, B., Damier, Philippe, Krack, Paul, Millet, B., Burbaud, P., Arbus, C., Pelissolo, A., Bataille, B., Dormont, D., Jaafari, Nematollah, Czernecki, Virginie, Derost, P., Bardinet, E., Du Montcel, Sophie Tezenas, Houeto, J. L., Polosan, Mircea, Burbaud, Pierre, Devaux, Bertrand, Bardinet, Eric, Mattei, Vianney, Aouizerate, Bruno, Aouizerate, B., Agid, Yves, Ardouin, Claire, Dormont, Didier, Damier, P., Benabid, A. L., Bougerol, Thierry, Fontaine, Denys, Ardouin, C., Krebs, Marie-Odile, Cornu, Philippe, Vérin, Marc, Agid, Y., Mallet, Luc, Houeto, Jean-Luc, Renseigné, Non, Baup, Nicolas, Chabardes, S., Raoul, Sylvie, Krebs, M. O., Chaynes, P., Czernecki, V., Yelnik, J., Mattei, V., Yelnik, Jérôme, Verin, M., Chereau, I., Raoul, S., Welter, Marie-Laure, Derost, Philippe, Bataille, Benoit, du Montcel, S. T.   +63 more
core   +1 more source

Muscarinic agonists for schizophrenia: Bridging preclinical evidence and clinical enthusiasm

British Journal of Pharmacology, Volume 183, Issue 19, Page 5701-5731, October 2026.
Abstract Antipsychotic drugs targeting dopamine receptors have been used to treat schizophrenia for decades, primarily alleviating positive symptoms such as hallucinations and delusions. However, they provide limited benefit for cognitive and negative symptoms—major contributors to poor outcomes—and are frequently associated with significant side ...
Brian J. Morris, Judith A. Pratt
wiley   +1 more source

A Toolkit for Targeted Neuromodulation of Striatal Direct Pathway Neurons Rescues Parkinsonian Motor Deficits in Mice

Advanced Science, Volume 13, Issue 49, 3 September 2026.
An adeno‐associated virus (AAV) toolkit enables selective anatomical and functional targeting of striatal D1‐MSNs through retrograde transduction. Enhanced capsids and engineered enhancers drive robust transgene expression across murine and primate models.
Zexuan Hong, Yujing Zhang, Junjiao Zhang, Hanhe Liu, Qiwei Liu, Yanglei Li, Lixin Yang, Lixia Li, Zhongjie Liu, Zhen Yuan, Zhonghua Lu, Yefei Chen, Yuantao Li, Yuwu Jiang, Taian Liu   +14 more
wiley   +1 more source

Dopamine regulates the impact of the cerebral cortex on the subthalamic nucleus-globus pallidus network.

, 2001
The subthalamic nucleus-globus pallidus network plays a central role in basal ganglia function and dysfunction. To determine whether the relationship between activity in this network and the principal afferent of the basal ganglia, the cortex, is altered
Bolam, JP, Bevan, MD, Magill, PJ, Magill, Peter   +3 more
core   +1 more source