Results 141 to 150 of about 351,721 (248)

Obsessive–Compulsive Disorder: Comorbidity, Biomarkers, Circuits, and Treatment Strategies

MedComm, Volume 7, Issue 11, November 2026.
OCD has a high comorbidity with other psychiatric conditions, among which anxiety is the most frequent one. The shared genetic biomarkers and common neural circuits underlying the co‐occurrence of OCD and anxiety pave a new path for understanding the pathogenic mechanism of OCD and suggest tailored and integrative treatment therapies for OCD from the ...
Xiao‐Yang Zhang, Zi‐Hao Li, Li‐Ping Shen, Bing‐Qing Kong, Qi‐Peng Zhang, Ya Ke, Juan Tu, Fei Wang, Wing‐Ho Yung, Jing‐Ning Zhu   +9 more
wiley   +1 more source

Auditory oddball responses in the human subthalamic nucleus and substantia nigra pars reticulata

Neurobiology of Disease
The auditory oddball is a mainstay in research on attention, novelty, and sensory prediction. How this task engages subcortical structures like the subthalamic nucleus and substantia nigra pars reticulata is unclear.
Dallas Leavitt, Frhan I. Alanazi, Tameem M. Al-Ozzi, Melanie Cohn, Mojgan Hodaie, Suneil K. Kalia, Andres M. Lozano, Luka Milosevic, William D. Hutchison   +8 more
doaj   +1 more source

Subthalamic Nucleus [PDF]

, 2020
openaire   +1 more source

Neurodegenerative Diseases: Epidemiology, Risk Factors, Classification, Pathophysiology, Clinical Features, Diagnosis, and Therapeutic Strategies

MedComm, Volume 7, Issue 11, November 2026.
Neurodegenerative diseases share convergent risk architectures and pathological mechanisms, yet diverge in selective vulnerability, clinical presentation, and therapeutic responsiveness. This review integrates cross‐disease epidemiology, pathophysiology, diagnosis, and treatment, highlighting the transition from symptomatic care toward biomarker‐guided
Zimeng He, Jingjing Zeng, Guoqing Wang, Yuxin Li, Feng Zhang   +4 more
wiley   +1 more source

GABAergic Network Dysregulation in Alcohol Use Disorder: Receptor–Transporter Interactions Driving the Transition From Goal‐Directed to Compulsive Behaviour

Addiction Biology, Volume 31, Issue 11, November 2026.
Astrocytic GAT3 regulates ambient GABA levels in the globus pallidus externus (GPe). Reduced GAT3 function enhances extrasynaptic GABAergic signalling and disrupts subthalamic nucleus (STN) regulation and cortical signal fidelity.ABSTRACTAlcohol use disorder (AUD) is characterized by a shift from controlled, goal‐directed drinking to compulsive ...
Hannah Aranda, Nathan Jones, Humza Haroon, Doo‐Sup Choi   +3 more
wiley   +1 more source

Decoding neuronal vulnerability: Multidimensional analysis of D1R‐ and D2R‐ medium‐sized spiny neurons in Huntington's disease

Brain Pathology, Volume 36, Issue 6, November 2026.
D1R and D2R MSNs show distinct responses to Huntington's pathology. G&T‐sequencing of pre‐symptomatic MSNs reveals global LINE‐1 downregulation. While D1R‐MSNs display early transcriptomic changes (OXPHOS/translation upregulation) and reduced mutant huntingtin aggregation, D2R‐MSNs exhibit higher nuclear mHTT accumulation and greater CAG somatic ...
Guendalina Bergonzoni, Miguel Pellegrini, Aurora Savino, Martina Lazioli, Sarah Geurs, Lorenzo Graziani, Denise Ferrarini, Solaleh Khoramian Tusi, Esaria Oliver, Jarne Geurts, Sara Vinciguerra, Michele Tebaldi, Takshashila Tripathi, Isabella Pesce, Valeria Poli, Alessandro Romanel, Rosario Moratalla, Thierry Voet, Jasmin Morandell, Remo Sanges, Vanessa C. Wheeler, Erik Dassi, Marta Biagioli   +22 more
wiley   +1 more source

Potentiation effects of the positive allosteric modulator PTC‐174 on NMDA receptors in neonatal male rat substantia nigra dopaminergic neurons

British Journal of Pharmacology, Volume 183, Issue 21, Page 6481-6500, November 2026.
Abstract Background and Purpose Positive allosteric modulators bind to secondary binding sites on the receptor and alter receptor conformation and activation, changing agonist potency and efficacy. PTC‐174 is a novel NMDA receptor positive allosteric modulator that particularly enhances activity of receptors containing GluN2C or GluN2D subunits.
Bangyuan Liu, Alasdair J. Gibb
wiley   +1 more source

Time to Move Upstream? A Framework for Expanding the Focus of Freezing of Gait to Prodromal, Subclinical, and Pre‐FOG Stages

European Journal of Neuroscience, Volume 64, Issue 9, November 2026.
Freezing of gait (FOG) is conceptualized as an upstream process evolving from vulnerability (Stages −3, prodromal), to subclinical (Stage −2) to downstream FOG expression (Stages −1, pre‐FOG and Stage 0, FOG episode). Earlier stages reflect underlying susceptibility, whereas later stages reflect the dynamic unfolding of freezing episodes.
Jeffrey M. Hausdorff, Kaylena A. Ehgoetz Martens, Moran Gilat, Jorik Nonnekes, Martina Mancini, J. Lucas McKay, Pieter Ginis, Jamie L. Adams, Jennifer R. Mammen, Erika E. Howe, Simon J. G. Lewis, Fay Horak, Alice Nieuwboer   +12 more
wiley   +1 more source

Inferior Frontal Gyrus Alterations in Freezing of Gait in Parkinson's Disease Without Evidence for Overall Hemispheric Lateralization: A Systematic Review and Activation Likelihood Estimation Meta‐Analysis

European Journal of Neuroscience, Volume 64, Issue 9, November 2026.
Our systematic review included 108 neuroimaging articles examining freezing of gait in Parkinson's disease, with 33 included in the primary activation likelihood estimation meta‐analysis. We assessed spatial convergence and hemispheric lateralization of reported abnormalities, identifying the right inferior frontal gyrus as the main convergent region ...
Seira Taniguchi, Hannah Deckmyn, Moran Gilat   +2 more
wiley   +1 more source

Neurophysiology of the subthalamic nucleus

, 2018
Having investigated high frequency firing in the STN, and how such increased levels of activity could influence co-ordinated firing within the STN, the effects of one of the STNs targets was assessed. Lesions of the globus pallidus have been shown to create a chronic increase in the levels of STN activity in vivo.
openaire   +1 more source