Results 111 to 120 of about 2,773 (218)

PCSK9 Inhibitors Reduce Oxidative Stress Biomarkers in Heterozygous Familial Hypercholesterolemia

Journal of Cellular and Molecular Medicine, Volume 30, Issue 10, May 2026.
ABSTRACT Proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors, such as alirocumab and evolocumab, effectively reduce LDL‐C levels, improve cardiovascular outcomes, and are well tolerated in the treatment of heterozygous familial hypercholesterolemia (HeFH).
Agnieszka Woźniak‐Szczepocka, Agnieszka Pawlos, Paulina Gorzelak‐Pabiś, Marlena Broncel, Bożena Bukowska, Ewelina Woźniak   +5 more
wiley   +1 more source

Autoactive MtDMI1 Reprogrammes Immunity and Development in Tomato via Ethylene Signalling

Plant Biotechnology Journal, Volume 24, Issue 5, Page 2861-2875, May 2026.
ABSTRACT The Common Symbiosis Signalling Pathway (CSSP) underpins interactions between plants and microbes, yet its potential for crop improvement remains underexplored. Here, we investigated the gain‐of‐function mutant SPD1 (MtDMI1S760N), which constitutively activates the symbiotic signalling pathway in Medicago truncatula, by expressing it in tomato
Haiyue Liu, Ji Xu, Fang Xie
wiley   +1 more source

Processing and release of endogenous immunogenic peptide signals

The Plant Journal, Volume 126, Issue 3, May 2026.
SUMMARY In both animals and plants, small secreted peptides known as cytokines and phytocytokines mediate local and systemic communication during immune and stress responses. These signaling molecules are typically synthesized as inactive precursors that require proteolytic processing to become active.
Maurice Koenig, Hermanyanto Laia, Gunther Doehlemann, Johana C. Misas Villamil   +3 more
wiley   +1 more source

Tempo and Mode of Spliceosomal Intron Evolution in Actin of Foraminifera [PDF]

, 2018
Spliceosomal introns are present in almost all eukaryotic genes, yet little is known about their origin and turnover in the majority of eukaryotic phyla.
Bolivar, Ignacio, Fahrni, José, Flakowski, Jérôme, Pawlowski, Jan   +3 more
core  

Safety evaluation of the food enzyme glutaminase from the genetically modified Bacillus subtilis strain Glu3‐3

EFSA Journal, Volume 24, Issue 5, May 2026.
Abstract The food enzyme glutaminase (l‐glutamine amidohydrolase; EC 3.5.1.2) is produced with the genetically modified Bacillus subtilis strain Glu3‐3 by Angel Yeast Co., Ltd. The production strain of the food enzyme contains multiple copies of acquired antimicrobial resistance genes.
EFSA Panel on Food Enzymes (FEZ), Holger Zorn, José Manuel Barat Baviera, Claudia Bolognesi, Francesco Catania, Gabriele Gadermaier, Ralf Greiner, Baltasar Mayo, Alicja Mortensen, Yrjö Henrik Roos, Marize L. M. Solano, Henk Van Loveren, Laurence Vernis, Jaime Aguilera, Magdalena Andryszkiewicz, Daniele Cavanna, Yi Liu   +16 more
wiley   +1 more source

Safety evaluation of an extension of use of the food enzyme subtilisin from the non‐genetically modified Bacillus licheniformis strain NZYM‐CX

EFSA Journal, Volume 24, Issue 5, May 2026.
Abstract The food enzyme subtilisin (EC 3.4.21.62) is produced with the non‐genetically modified Bacillus licheniformis strain NZYM‐CX by Novozymes A/S. The safety of this food enzyme was evaluated previously and it did not give rise to safety concerns when used in eight food manufacturing processes.
EFSA Panel on Food Enzymes (FEZ), Holger Zorn, José Manuel Barat Baviera, Claudia Bolognesi, Francesco Catania, Gabriele Gadermaier, Ralf Greiner, Baltasar Mayo, Alicja Mortensen, Yrjö Henrik Roos, Marize L. M. Solano, Henk Van Loveren, Laurence Vernis, Anna Ferrandis Rosell, Daniele Cavanna, Yi Liu   +15 more
wiley   +1 more source

Safety of oil from Schizochytrium sp. A2 for use in infant and follow‐on formula as a novel food pursuant to regulation (EU) 2015/2283

EFSA Journal, Volume 24, Issue 5, May 2026.
Abstract Following a request from the European Commission, the EFSA Panel on Nutrition, Novel Foods and Food Allergens (NDA) was asked to deliver an opinion on the safety of an oil derived from the microalga‐like organism Schizochytrium sp. A2 as a novel food (NF) pursuant to Regulation (EU) 2015/2283.
EFSA Panel on Nutrition, Novel Foods and Food Allergens (NDA), Dominique Turck, Torsten Bohn, Montaña Cámara, Jacqueline Castenmiller, Stefaan De Henauw, Ángeles Jos, Alexandre Maciuk, Inge Mangelsdorf, Breige McNulty, Androniki Naska, Kristina Pentieva, Alfonso Siani, Frank Thies, Thomas Frenzel, Margarita Aguilera‐Gómez, Francesca Marcon, Monika Neuhäuser‐Berthold, Irene Nuin Garciarena, Emanuela Turla, Areti Favata, Karen Ildico Hirsch‐Ernst   +22 more
wiley   +1 more source

Subtilisin Carlsberg

Journal of Biological Chemistry, 1968
R J DeLange, E L Smith
  +4 more sources

Evaluation of evolocumab on saphenous vein graft patency following coronary artery bypass graft surgery in people living with and without diabetes in the NEWTON‐CABG CardioLink‐5 trial

Diabetes, Obesity and Metabolism, Volume 28, Issue 5, Page 4376-4381, May 2026.
Hwee Teoh, Subodh Verma, G. B. John Mancini, Adrian Quan, Michael Szarek, Randi Elituv, Meena Verma, Elizabeth Misner, Aishwarya Krishnaraj, Peter Jüni, Michael J. Koren, Stephen J. Nicholls, Deepak L. Bhatt, C. David Mazer, Lawrence A. Leiter   +14 more
wiley   +1 more source

Protein engineering on subtilisin

International Journal of Biochemistry, 1991
openaire   +5 more sources