Results 181 to 190 of about 2,773 (218)
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Protein engineering of subtilisin
Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology, 2000The serine protease subtilisin is an important industrial enzyme as well as a model for understanding the enormous rate enhancements affected by enzymes. For these reasons along with the timely cloning of the gene, ease of expression and purification and availability of atomic resolution structures, subtilisin became a model system for protein ...
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SUBTILISIN: AN ENZYME DESIGNED TO BE ENGINEERED
Trends in Biochemical Sciences, 1988Abstract Almost every property of subtilisin, a simple bacterial serine protease, has been altered by protein engineering including its catalysis, substrate specificity, pH/rate profile, and stability to oxidative, thermal and alkaline inactivation.
J A, Wells, D A, Estell
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Alkaline-Resistance Model of Subtilisin ALP I, a Novel Alkaline Subtilisin
Journal of Biochemistry, 2001The alkaline-resistance mechanism of the alkaline-stable enzymes is not yet known. To clarify the mechanism of alkaline-resistance of alkaline subtilisin, structural changes of two typical subtilisins, subtilisin ALP I (ALP I) and subtilisin Sendai (Sendai), were studied by means of physicochemical methods.
H, Maeda +4 more
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Crystal structures of Streptomyces subtilisin inhibitor and its complex with subtilisin BPN′
Nature, 1979Crystal structure of a microbial protein proteinase inhibitor SSI (Streptomyces subtilisin inhibitor) and its complex with subtilisin BPN′ were solved at 2.6 A and 4.3 A resolution respectively. The mode of binding to the proteinase of SSI is compared with that of bovine pancreatic trypsin inhibitor, soybean trypsin inhibitor and the substrates ...
Y, Mitsui +4 more
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Degradation of ribonuclease by subtilisin
Biochimica et Biophysica Acta, 1955S M, KALMAN +3 more
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Biochemistry. Biokhimiia, 1999
This review presents a systematization of available data on subtilisin-like serine proteinases of plants. Enzymatic and physicochemical properties of the enzymes, their structure and processing, as well as their biological functions and origin are considered.
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This review presents a systematization of available data on subtilisin-like serine proteinases of plants. Enzymatic and physicochemical properties of the enzymes, their structure and processing, as well as their biological functions and origin are considered.
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The activation of chymotrypsinogen by subtilisin
Biochimica et Biophysica Acta, 1956A, BRONFENBRENNER +2 more
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