Results 71 to 80 of about 5,618 (220)
Obesity and hypertension co‐exist and share molecular mechanisms in terms of dietary therapy, modulated by food bioactive constituents. ABSTRACT Obesity and hypertension are among the most pressing global public health challenges. They frequently co‐exist, with obesity‐related hypertension accounting for an estimated 75% of the hypertension burden ...
Samuel Oluwasegun Maccarthy +3 more
wiley +1 more source
Certain beneficial fungi are widely used to control harmful nematodes in crops, especially when combined with organic matter. Together, they improve soil health, support plant growth, and enhance nutrient cycling. This natural partnership offers a promising, environmentally friendly approach to strengthening sustainable agriculture and reducing ...
Ndivhuwo Ramatsitsi +2 more
wiley +1 more source
NbRD21 protease controls receptor kinase homeostasis in Nicotiana benthamiana
Proteomic analysis revealed that receptor kinases (red) accumulate higher in rd21 knockout Nicotiana benthamiana plants. Summary RD21‐like proteases are papain‐like cysteine proteases with a C‐terminal granulin domain that are abundant and ubiquitous in angiosperms and have often been implicated in immunity.
Alice Godson +13 more
wiley +1 more source
A structure‐informed, fragment‐based approach was used to identify non‐peptidomimetic inhibitors of plasmepsin V. Pyrrolidine, piperidine, and piperazine containing fragments showed activity in a FRET assay. The optimization of the pyrrolidine scaffold resulted in N‐sulfonamide analogs with potency up to ~10 µM, establishing a promising scaffold for ...
Marija Skvorcova +4 more
wiley +1 more source
Schematic representation of the balloon passage via microwire navigation technology. ABSTRACT This case presents that balloon passage via microwire navigation technology could be a beneficial option for patients with severe MCA stenosis, with the diameter of the proximal blood vessel in the stenotic segment is < 1.5 mm and there is antegrade blood flow.
Yang Gao +10 more
wiley +1 more source
In cardiac cells, Plin5/AMPK regulate lipid homeostasis; excess CD36‐mediated uptake drives lipotoxicity, mitochondrial dysfunction, and CVDs (e.g., heart failure). Biomarkers (ApoB/ApoA‐1) and therapies (SGLT2 inhibitors) target this cascade. ABSTRACT Cardiac lipid metabolism is fundamental to myocardial energy homeostasis, with fatty acid oxidation ...
Peiyun Xie +3 more
wiley +1 more source
Abstract Evaluation of the pharmacokinetics (PK) of new drugs in Japanese individuals is regularly requested by the Japanese regulatory agency prior to participation in global clinical trials or for bridging approaches for regulatory approval. However, the need for PK assessments in the Japanese population may be less compelling for monoclonal ...
Paridhi Gupta +2 more
wiley +1 more source
New robust subtilisins from halotolerant and halophilic Bacillaceae. [PDF]
Falkenberg F +4 more
europepmc +1 more source

