Results 101 to 110 of about 2,709,938 (252)

Preventing cognitive decline and dementia a way forward

, 2017
"Societies around the world are concerned about dementia and the other forms of cognitive impairment that affect many older adults. We now know that brain changes typically begin years before people show symptoms, which suggests a window of opportunity ...
Leshner, Alan I.
core  

Bioinspired Adaptive Sensors: A Review on Current Developments in Theory and Application

Advanced Materials, EarlyView.
This review comprehensively summarizes the recent progress in the design and fabrication of sensory‐adaptation‐inspired devices and highlights their valuable applications in electronic skin, wearable electronics, and machine vision. The existing challenges and future directions are addressed in aspects such as device performance optimization ...
Guodong Gong, You Zhou, Qingxiu Li, Wenyu Zhao, Sunyingyue Geng, Hangfei Li, Yan‐Bing Leng, Shirui Zhu, Guanglong Ding, Yongbiao Zhai, Ziyu Lv, Ye Zhou, Su‐Ting Han   +12 more
wiley   +1 more source

Toward Perception‐Native Electronic Skin: Bio‐Inspired In‐/Near‐Sensor and Neuromorphic Computing for Humanoid Robots

Advanced Materials Technologies, EarlyView.
Dense tactile streams from across the humanoid body converge on collide in a central wiring and data bottleneck. By relocating computation closer to and then into the skin itself, near‐ and in‐sensor architectures, together with neuromorphic computing, chart a path toward perception‐native electronic skin, in which the conversion of stimulus into ...
Mijin Kim, Chang‐Jae Beak, Jiyoung Park, Youngdo Jung, Sunjong Oh, Sin‐Hyung Lee, Bo‐Yeon Lee   +6 more
wiley   +1 more source

Radiation-Induced Cognitive Decline: Challenges and Solutions [PDF]

Parisa Shamsesfandabadi,1 Arpeet Patel,2 Yun Liang,1 Matthew J Shepard,3 Rodney E Wegner1 1Radiation Oncology department, Allegheny Health Network, Pittsburgh, PA, USA; 2Drexel University College of Medicine, Philadelphia, PA, USA; 3Neurosurgery ...
Patel A, Wegner RE, Liang Y, Shamsesfandabadi P, Shepard MJ   +4 more
core  

Multimodal Engagement Assessment in Children During Invented Story Paradigm With a Social Robot

Advanced Robotics Research, EarlyView.
A multimodal framework is proposed to assess children's engagement during storytelling interactions with a social robot. Gaze, physiological, and behavioral data are combined and validated against observer ratings. An automated gaze‐labeling strategy is introduced, and supervised classifiers achieve high accuracy. The study supports scalable engagement
Laura Fiorini, Elena Adelucci, Stefano Scatigna, Lorenzo Pugi, Alice Bruni, Benedetta Carotenuto, Chiara Pecini, Filippo Cavallo   +7 more
wiley   +1 more source

Smartphone-based detection of subtle memory decline in prodromal Alzheimer’s disease

npj Digital Medicine
The slow progression of Alzheimer’s disease (AD) poses a challenge for the quantification of early disease-driven cognitive decline. Here, we show that frequently administered remote and unsupervised digital cognitive assessments can detect differences ...
Sarah E. Polk, Lindsay R. Clark, Kristin Basche, Luca Kleineidam, Wenzel Glanz, Michaela Butryn, Robert Perneczky, Katharina Buerger, Klaus Fliessbach, Christoph Laske, Annika Spottke, Anja Schneider, Jens Wiltfang, Stefan Teipel, Claudia Bartels, Ayda Rostamzadeh, Daniel Janowitz, Boris-Stephan Rauchmann, Ingo Kilimann, Sebastian Sodenkamp, Marie Coenjaerts, Frederic Brosseron, Michael Wagner, Ingo Frommann, Melina Stark, Matthias Schmid, Björn H. Schott, Sterling C. Johnson, Frank Jessen, Emrah Düzel, David Berron   +30 more
doaj   +1 more source

Modulation of miR‐23b Wnt/β‐catenin Axis Strengthens Endothelial Barrier Properties

Advanced Science, EarlyView.
Early blood‐brain barrier (BBB) disruption contributes to stroke and CNS disease pathology. miR‐23b was identified as a regulator of BBB integrity in brain endothelial cells. Inhibition of miR‐23b enhanced barrier‐associated properties, promoted repair‐related signaling, and reduced BBB leakage in experimental stroke models, supporting further ...
Victor Anthony Martinez, Rose E. Presby, Sara Nakanishi, Pallavi Gaur, Ugur Akcan, Johannes Daugaard Krog, Iben Daugaard Krog, Lipi Das, David S. Johnson, Danny Jamoul, Douglas Jury, Brian Lawson, Jacob Körbelin, Lewis M. Brown, Vilas Menon, Dritan Agalliu, Irene Munk Pedersen   +16 more
wiley   +1 more source

Subjective memory complaints are associated with altered resting-state functional connectivity but not structural atrophy

NeuroImage: Clinical, 2019
Research indicates that a subtle cognitive decline, accompanied by pathological changes, occurs in individuals with subjective memory complaints (SMC). However, there is less evidence regarding the measurement of resting-state functional connectivity to ...
Toshikazu Kawagoe, Keiichi Onoda, Shuhei Yamaguchi   +2 more
doaj   +1 more source

Disrupted TFEB/GDNF–cAMP/ATP Coupling Underlies Astrocytic Dysfunction and Depression in LRRK2 G2019S Parkinson's Mice

Advanced Science, EarlyView.
ABSTRACT The LRRK2 G2019S mutation, a Parkinson's disease–linked variant, has been associated with depression‐like phenotypes, but mechanisms remain unclear. We chart age‐dependent behavioral changes and astrocyte reactivity in G2019S mice and define a pathway connecting LRRK2 to TFEB/GDNF signaling, cellular energetics, and inflammation.
Longping Yao, Maryam Hatami, Sumeyye Koc, Qing Jiang, Thomas Skutella, Yuanfeng Zhang   +5 more
wiley   +1 more source

Molecular pathways and biomarkers associated with age-related cognitive decline

Academia Biology
Age-related cognitive decline is the gradual decrease in memory, reduced attention, difficulty with multitasking, reduced ability to recall information, and decreased processing speed with age. These changes are considered normal, and the rate
Shreyasi Mitra, Sampoorn Pandey, Aman Gill, Anannya Roy, Shibam Dutta, Amit Kumar, Majid Ali, Geetanjali Chawla   +7 more
doaj   +1 more source