Results 81 to 90 of about 2,709,938 (252)

Human Pegivirus Encephalitis With Brain Detection and Response to Sofosbuvir Ledipasvir

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Human pegivirus (HPgV‐1) has been associated with severe encephalomyelitis in immunocompromised patients. Its neurological spectrum remains poorly defined. We report a slowly progressive encephalitis in a person living with well‐controlled HIV, characterized by white matter abnormalities and inflammatory cerebrospinal fluid (CSF). HPgV RNA was
Antoine Moulignier, Françoise Heran, Francis Lallemand, Pierre Bourdillon   +3 more
wiley   +1 more source

Subtle Objective and Subjective Cognitive Decline Predict Risk of Dementia

Alzheimer's & Dementia
Abstract Background Subjective cognitive decline (SCD) has been linked to an increased risk of progression to mild cognitive impairment (MCI) and dementia. Furthermore, informant confirmation of SCD has been associated with a higher likelihood of future decline than participant‐reported SCD ...
Kim, Jonathan S, Farahmand, Ghasem, Corona, Maria G, Nan, Bin, Zou, April, Sajjadi, Seyed Ahmad   +5 more
openaire   +2 more sources

The influence of life course socioeconomic position on cognitive function and cognitive decline in older age: the impact of missing data [PDF]

, 2012
Cognitive function has been associated with many physical and mental health conditions, as well as mortality. Cognitive decline is one aspect of ageing that causes anxiety among the general population.
Landy, R
core  

Digital Cognitive Phenotyping for Differential Diagnosis and Monitoring in Neurological Conditions

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To assess the utility, accessibility, and equivalence to supervised scales of online cognitive assessment in older individuals with cognitive impairment. Methods Patients with Alzheimer's disease (AD, n = 31), idiopathic normal pressure hydrocephalus (iNPH, n = 26), and traumatic brain injury (TBI, n = 23) completed online cognitive ...
Martina Del Giovane, Valentina Giunchiglia, Michael C. B. David, Magdalena A. Kolanko, William R. Trender, Peter J. Hellyer, Harmeena Kaur, David J. Sharp, Christopher Carswell, Paresh A. Malhotra, Adam Hampshire   +10 more
wiley   +1 more source

Digital Cognitive Testing in Mitochondrial Disease: Validity and Challenges for Clinical Trial Use

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Primary mitochondrial disease is a group of genetic disorders caused by pathogenic variants in nuclear or mitochondrial DNA, often resulting in progressive neurodegeneration and cognitive decline. Current management is primarily supportive, though recent research offers hope for disease‐modifying treatments in the future.
Oksana Pogoryelova, Jan Smeitink, Herma Renkema, Rosabeth White, Frankie Barton, Rachel Lyon, Jane Newman, Aye Moe, Yi Shiau Ng, Grainne Siobhan Gorman   +9 more
wiley   +1 more source

Hearing loss and cognitive decline in older adults: questions and answers.

, 2014
The association between hearing impairment, the diagnosis of dementia, and the role of sensory therapy has been proposed for some time, but further research is needed. Current understanding of this association requires the commitment of those experts
Memo M, Marengoni A, Pecorelli S, Maggi S, Bernabei R, Bonuccelli U, QUARANTA, Nicola Antonio Adolfo, Lin FR, For the participants in the Workshop on Hearing Loss, Martini A, Peracino AP, Cognitive Decline in Older Adults, Stella R   +12 more
core   +2 more sources

Minimum pulse rate during sleep as a MMSE-associated factor: a multifaceted exploratory study in older adults without long-term care certification

BMC Geriatrics
Background Developing quantitative indicators of daily life that detect subtle cognitive decline is an important challenge in today's growing population of older adults worldwide.
Yuji Tanaka, Kozo Saito, Kyoichiro Tsuchiya, Yusuke Iwata, Takashi Ando, Kazuki Mochizuki, Tamami Taniguchi, Takahiko Mitsui   +7 more
doaj   +1 more source

MRI-Driven Longitudinal Studies of Hippocampal Alterations During the Initial Cognitive Decline

IEEE Journal of Translational Engineering in Health and Medicine
Based on available magnetic resonance imaging (MRI) studies, hippocampal alteration is one of the hallmarks during cognitive decline. However, the longitudinal hippocampal morphometric changes during the initial cognitive decline are unclear. Exploring a
Qunxi Dong, Yuhang Sheng, Junru Zhu, Honghong Liu, Zhigang Li, Jingyu Liu, Yalin Wang, Bin Hu   +7 more
doaj   +1 more source

Characterizing Cutaneous α‐Synuclein Deposition and Seeding Activity in Parkinson's Disease Subtypes

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Cutaneous phosphorylated α‐synuclein (p‐syn) and α‐synuclein seeding activity are promising biomarkers for Parkinson's disease (PD), but their clinical value remains uncertain due to disease heterogeneity. This study evaluates these two biomarkers in PD patients to inform phenotype‐specific diagnosis and disease severity assessment ...
Yuting Jin, Tianyuan Yang, Minglei Liu, Haiyang Luo, Jing Yuan, Ke Zhang, Xinsheng Han, Jing Yang, Yuming Xu   +8 more
wiley   +1 more source

Sarcopenic Obesity and Longitudinal Trajectories on Cognitive Performance and Subtle Cognitive Impairment Over 6 Years in Older Adults

Journal of Cachexia, Sarcopenia and Muscle
Background Sarcopenic obesity has been suggested as a potential risk factor for cognitive decline; however, few prospective studies have been conducted to test this hypothesis. We aimed to assess the relationship between baseline sarcopenic obesity and 6‐
Héctor Vázquez‐Lorente, Indira Paz‐Graniel, Hernando J. Margara‐Escudero, Miguel Ángel Martínez‐González, Dora Romaguera, D. Martinez Urbistondo, Ramon Estruch, Vicente Martín Sánchez, Josep Vidal, Montserrat Fitó, Nuria Goñi, Alice Chaplin, M. Angeles Zulet, Emilio Sacanella, José Antonio dePaz Fernández, Andreu Altés, Jesús F. García‐Gavilán, Jadwiga Konieczna, J. Alfredo Martínez, Jordi Salas‐Salvadó   +19 more
doaj   +1 more source