Results 61 to 70 of about 2,709,938 (252)

Informant reported cognitive decline in older adults [PDF]

, 2017
Objectives: Gaining an informant’s perspective on cognitive decline has become an increasingly popular, and recommended practice, in the assessment of dementia. However, concern regarding the accuracy of such reports has been documented.
Morrell, L.
core  

[18F]Fluorodeprenyl‐D2 PET as a Tool to Monitor Disease Activity in GAD65‐Ab Autoimmune Encephalitis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To evaluate [18F]fluorodeprenyl‐D2 ([18F]F‐DED) positron‐emission tomography (PET) imaging as a biomarker of disease activity in autoimmune encephalitis (AIE) associated with glutamic acid decarboxylase 65 (GAD65) antibodies. Methods [18F]F‐DED PET was performed in 25 GAD65‐AIE patients and 8 controls using dynamic (0–60 min) and ...
Julia S. Dorneich, Jonathan A. Gernert, Hanna Zimmermann, Lisa Tagnin, Marianthi Zeinaki, Laura Sanzo, Letizia Vogler, Elisabeth Kaufmann, Justina Dargvainiene, Frank Leypoldt, Gérard N. Bischof, Robert Perneczky, Boris‐Stephan Rauchmann, Simon Lindner, Günter U. Höglinger, Rudolf A. Werner, Martin Kerschensteiner, Tania Kümpfel, Matthias Brendel, Franziska S. Thaler   +19 more
wiley   +1 more source

Objective Criteria for Subtle Cognitive Decline in Aging and Preclinical AD: A Systematic Review [PDF]

Alzheimers Dement
AbstractBackgroundThe field of Alzheimer’s disease and related dementias (ADRD) has continued to move toward earlier detection. Within the 2018 NIA‐AA AD Research Framework, clinical stage 2 recognizes that someone can be cognitively unimpaired but still experience “subtle cognitive decline” as measured by subjective report or evidence of objective ...
Thomas K, Edmonds E.
europepmc   +2 more sources

Comparing the Effect of Semi‐Immersive Virtual Reality, Computerized Cognitive Training, and Traditional Rehabilitation on Cognitive Function in Multiple Sclerosis: A Randomized Clinical Trial

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Cognitive impairment is a common non‐motor symptom in Multiple Sclerosis (MS), negatively affecting autonomy and Quality of Life (QoL). Innovative rehabilitation strategies, such as semi‐immersive virtual reality (VR) and computerized cognitive training (CCT), may offer advantages over traditional cognitive rehabilitation (TCR ...
Maria Grazia Maggio, Desiree Latella, Lilla Bonanno, Paulo Cezar Rocha dos Santos, Marcos Maldonado‐Díaz, Meir Plotnik, Rosaria De Luca, Angelo Quartarone, Rocco Salvatore Calabrò   +8 more
wiley   +1 more source

Prodromal Lewy Body Disorder Features in REM Sleep Behavior Disorder With Biomarker‐Defined Synucleinopathy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Isolated rapid eye movement sleep behavior disorder (iRBD) is a prodromal state for Lewy body disorders and exhibits biological heterogeneity that may influence clinical expression and progression. We examined clinical features in individuals with iRBD and biomarker‐defined synucleinopathy.
Daniel Weintraub, Michele K. York, Roseanne Dobkin, Anuprita R. Nair, Ryan Kurth, David‐Erick Lafontant, Chelsea Caspell‐Garcia, Roy N. Alcalay, Ethan G. Brown, Lana M. Chahine, Christopher Coffey, Tatiana Foroud, Douglas Galasko, Karl Kieburtz, Kenneth Marek, Kalpana Merchant, Brit Mollenhauer, Kathleen L. Poston, Andrew Siderowf, Cristina Simonet, Tanya Simuni, Caroline M. Tanner, Thomas F. Tropea, Aleksandar Videnovic, The Parkinson's Progression Markers Initiative   +24 more
wiley   +1 more source

Effects of metabolic syndrome, apolipoprotein E, and CYP46 on cognition among Taiwanese Chinese

Kaohsiung Journal of Medical Sciences, 2014
The combined effects of metabolic syndrome and the apolipoprotein E and CYP46 genotypes on the risk of cognitive decline has yet to be determined among Taiwanese Chinese.
Chiou-Lian Lai, Li-Min Liou, Ching-Kuan Liu, Yuan-Han Yang, Ruey-Tay Lin   +4 more
doaj   +1 more source

Poor decision making is a consequence of cognitive decline among older persons without Alzheimer's disease or mild cognitive impairment. [PDF]

PLoS ONE, 2012
Decision making is an important determinant of health and well-being across the lifespan but is critical in aging, when many influential decisions are made just as cognitive function declines.
Patricia A Boyle, Lei Yu, Robert S Wilson, Keith Gamble, Aron S Buchman, David A Bennett   +5 more
doaj   +1 more source

Evaluation of Digital Technologies for Home‐Based Assessment in People With Amyotrophic Lateral Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Digital technologies hold promise for transforming healthcare by enhancing personalized treatments and offer valuable opportunities to improve patient care. Here, we evaluated several novel, self‐administered, home‐based, digital endpoints for their association with corresponding conventional standard clinical measures (primary) in ...
Arne Mueller, Vanessa Vallejo, Mónica Povedano Panadés, Orla Hardiman, Véronique Danel‐Brunaud, Senda Ajroud‐Driss, Philippe Couratier, Jeremy Shefner, Anna Gokey, Mike DiCesare, Erin Lennox, Jens Praestgaard, Lucie Brujin, Peggy Allred, Ram Miller   +14 more
wiley   +1 more source

Cognitive performance before and after the onset of subjective cognitive decline in old age

Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, 2015
Background Our objectives were (1) to test the association between the report of subjective cognitive decline (SCD) and prospective objective cognitive performance in high age individuals and (2) to study the course of longitudinal cognitive performance ...
Alexander Koppara, Michael Wagner, Carolin Lange, Annette Ernst, Birgitt Wiese, Hans‐Helmut König, Christian Brettschneider, Steffi Riedel‐Heller, Melanie Luppa, Siegfried Weyerer, Jochen Werle, Horst Bickel, Edelgard Mösch, Michael Pentzek, Angela Fuchs, Steffen Wolfsgruber, André Beauducel, Martin Scherer, Wolfgang Maier, Frank Jessen   +19 more
doaj   +1 more source

Medical Foods and Dietary Approaches in Cognitive Decline, Mild Cognitive Impairment, and Dementia

, 2015
There has been considerable research focused on effective dietary interventions that may prevent or ameliorate age-related cognitive decline, mild cognitive impairment, and dementia (e.g., Alzheimer’s disease). Results from numerous observational studies
James E. Galvin, Galvin, James E.
core   +1 more source