Results 41 to 50 of about 43,561 (219)

Symposium 13: Prediabetes and brain

Revista de la Sociedad Argentina de Diabetes, 2022
Prediabetes is a serious but reversible problem characterized by hyperglycemia and insulin resistance1. Decline in β-cell function was seen in prediabetes due to metabolic and epigenetic changes and alterations at the level of its cellular biology ...
Gustavo Díaz
doaj   +1 more source

An explainable machine learning model of cognitive decline derived from speech

Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, 2023
INTRODUCTION Traditional Alzheimer's disease (AD) and mild cognitive impairment (MCI) screening lacks the sensitivity and timeliness required to detect subtle indicators of cognitive decline.
Chelsea Chandler, Catherine Diaz‐Asper, Raymond S. Turner, Brigid Reynolds, Brita Elvevåg   +4 more
doaj   +1 more source

Low thalamic activity during a digit-symbol substitution task is associated with symptoms of subjective cognitive decline

Frontiers in Psychiatry, 2023
IntroductionSubjective cognitive decline (SCD) may represent the earliest preclinical stage of Alzheimer's Disease (AD) for some older adults. However, the underlying neurobiology of SCD is not completely understood.
Akiko Mizuno, Helmet Talib Karim, Helmet Talib Karim, Maria J. Ly, Maria J. Ly, Brian J. Lopresti, Ann D. Cohen, Areej A. Ali, Chester A. Mathis, William E. Klunk, Howard J. Aizenstein, Howard J. Aizenstein, Beth E. Snitz   +12 more
doaj   +1 more source

Management of patients with pre-dementia cognitive impairment

Российский журнал гериатрической медицины
Cognitive disorders are one of the most significant problems for elderly and senile people. Particular attention should be paid to the diagnosis of early pre-dementia stages of cognitive impairment: subjective and subtle cognitive decline and mild ...
N. N. Koberskaya
doaj   +1 more source

Effects of non-pharmacological or pharmacological interventions to promote cognition and brain plasticity in aging individuals

Frontiers in Systems Neuroscience, 2014
Brain aging and aging-related neurodegenerative disorders are major health challenges faced by modern societies. Brain aging is associated with cognitive and functional decline and represents the favourable background for the onset and development of ...
Valentina ePieramico, Roberto eEsposito, Stefano eCesinaro, Valerio eFrazzini, Stefano Luca Sensi, Stefano Luca Sensi, Stefano Luca Sensi   +6 more
doaj   +1 more source

Conventional clock drawing tests have low to moderate reliability and validity for detecting subtle cognitive impairments in community-dwelling older adults

Frontiers in Aging Neuroscience, 2023
BackgroundEarly identification of subtle cognitive decline in community-dwelling older adults is critical, as mild cognitive impairment contributes to disability and can be a precursor to dementia.
Kristen E. Kehl-Floberg, Timothy S. Marks, Dorothy F. Edwards, Dorothy F. Edwards, Gordon M. Giles   +4 more
doaj   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Five‐Year Disease Progression in Synuclein Seeding Positive Sporadic Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To provide a comprehensive description of disease progression in synuclein seeding assay (SAA) positive sporadic Parkinson Disease participants, using Neuronal Synuclein Disease integrated biological and functional impairment staging framework.
Paulina Gonzalez‐Latapi, Caroline Gochanour, Seung Ho Choi, Hyunkeun Cho, Chelsea Caspell‐Garcia, Christopher Coffey, Michael Brumm, David‐Erick Lafontant, Yuge Xiao, Thomas Tropea, John Seibyl, Caroline Tanner, Charles S. Venuto, Karl Kieburtz, Lana M. Chahine, Kathleen L. Poston, Andrew Siderowf, Kenneth Marek, Tanya Simuni, The Parkinson's Progression Markers Initiative   +19 more
wiley   +1 more source

Location‐Specific Hematoma Volume Predicts Early Neurological Deterioration in Supratentorial ICH

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Early neurological deterioration (END) adversely affects outcomes in patients with intracerebral hemorrhage (ICH). This study aimed to determine the location‐specific hematoma volumes for END in supratentorial ICH patients. Methods We retrospectively analyzed supratentorial ICH patients presenting from two prospective cohorts.
Zuoqiao Li, Guilin Meng, Zijie Wang, Xiao Hu, Jing Cheng, Chu Chen, Tiannan Yang, Jiaxin Luo, Zizhen Meng, Xueyun Liu, Qi Li   +10 more
wiley   +1 more source

Effects of metabolic syndrome, apolipoprotein E, and CYP46 on cognition among Taiwanese Chinese

Kaohsiung Journal of Medical Sciences, 2014
The combined effects of metabolic syndrome and the apolipoprotein E and CYP46 genotypes on the risk of cognitive decline has yet to be determined among Taiwanese Chinese.
Chiou-Lian Lai, Li-Min Liou, Ching-Kuan Liu, Yuan-Han Yang, Ruey-Tay Lin   +4 more
doaj   +1 more source