Results 21 to 30 of about 43,561 (219)

Clinical meaningfulness of subtle cognitive decline on longitudinal testing in preclinical AD. [PDF]

Alzheimers Dement, 2020
AbstractIntroductionDemonstrating the “clinical meaningfulness” of slowing early cognitive decline in clinically normal (CN) older adults with elevated amyloid‐β (Aβ+) is critical for Alzheimer's disease secondary prevention trials and for understanding early cognitive progression.MethodsCox regression analyses were used to determine whether 3‐year ...
Papp KV, Buckley R, Mormino E, Maruff P, Villemagne VL, Masters CL, Johnson KA, Rentz DM, Sperling RA, Amariglio RE, Collaborators from the Harvard Aging Brain Study, the Alzheimer's Disease Neuroimaging Initiative and the Australian Imaging, Biomarker and Lifestyle Study of Aging.   +12 more
europepmc   +3 more sources

Beyond PD-MCI: objectively defined subtle cognitive decline predicts future cognitive and functional changes. [PDF]

J Neurol, 2021
Cognitive impairment is prevalent among individuals with Parkinson's disease (PD). Effort has been made to identify individuals at risk for cognitive decline and dementia. Objectively-defined subtle cognitive decline (Obj-SCD) is a novel classification that may identify individuals at risk for cognitive decline prior to a diagnosis of mild cognitive ...
Jones JD, Uribe C, Bunch J, Thomas KR.
europepmc   +4 more sources

Subtle Cognitive Decline and Biomarker Staging in Preclinical Alzheimer's Disease. [PDF]

J Alzheimers Dis, 2015
The NIA-AA criteria for “preclinical” Alzheimer’s disease (AD) propose a staging method in which AD biomarkers follow an invariable temporal sequence in accordance with the amyloid cascade hypothesis. However, recent findings do not align with the proposed temporal sequence and “subtle cognitive decline,” which has not been definitively operationalized,
Edmonds EC, Delano-Wood L, Galasko DR, Salmon DP, Bondi MW, Alzheimer’s Disease Neuroimaging Initiative.   +5 more
europepmc   +6 more sources

Alteration of functional connectivity network in population of objectively-defined subtle cognitive decline. [PDF]

Brain Commun, 2023
Abstract The objectively-defined subtle cognitive decline individuals had higher progression rates of cognitive decline and pathological deposition than healthy elderly, indicating a higher risk of progressing to Alzheimer’s disease. However, little is known about the brain functional alterations during this stage.
Zhang X, Zeng Q, Wang Y, Jin Y, Qiu T, Li K, Luo X, Wang S, Xu X, Liu X, Zhao S, Li Z, Hong L, Li J, Zhong S, Zhang T, Huang P, Zhang B, Zhang M, Chen Y.   +19 more
europepmc   +3 more sources

Pre-dementia cognitive impairment

Российский журнал гериатрической медицины, 2022
Cognitive disorders are one of the most significant problems of older. Special attention should be paid to the diagnosis of early pre-dementia stages of cognitive impairment (CI): subjective, subtle and mild.The aim of this study was to determine the ...
N. N. Koberskaya, E. A. Mkhitaryan, A. B. Lokshina, D. A. Grishina   +3 more
doaj   +1 more source

Influence of genetic and comorbid emotional-affective factors on pre-mild cognitive decline in middle-aged patients

Неврология, нейропсихиатрия, психосоматика, 2021
Recently, maximum attention has been drawn to the earliest forms of cognitive deficit - pre-mild cognitive decline (PMCD), which includes subjective (SjCD) and subtle cognitive decline (SCD), being the most promising in cognitive decline prevention ...
N. N. Koberskaya, T. M. Ostroumova, V. A. Perepelov, D. S. Smirnov   +3 more
doaj   +1 more source

Neuropsychological Decline Stratifies Dementia Risk in Cognitively Unimpaired and Impaired Older Adults

Frontiers in Aging Neuroscience, 2022
ObjectiveValidation and widespread use of markers indicating decline in serial neuropsychological exams has remained elusive despite potential value in prognostic and treatment decision-making.
Jean K. Ho, Daniel A. Nation, Daniel A. Nation   +2 more
doaj   +1 more source

Objective Criteria for Subtle Cognitive Decline in Aging and Preclinical Alzheimer Disease: A Systematic Review. [PDF]

Neurology
Although the Alzheimer's Association (AA) biomarker-only Alzheimer disease (AD) criteria and the International Working Group clinical-pathologic AD criteria differ, both approaches appreciate the need for early detection efforts. Within the AA approach, clinical stage 2 recognizes that someone can be cognitively unimpaired but still experience "subtle ...
Thomas KR, Edmonds EC.
europepmc   +3 more sources

Hippocampal and Amygdala Gray Matter Loss in Elderly Controls with Subtle Cognitive Decline. [PDF]

Front Aging Neurosci, 2017
In contrast to the idea that hippocampal and amygdala volume loss occur in late phases of neurodegeneration, recent contributions point to the relevance of preexisting structural deficits that are associated with aging and are independent of amyloid deposition in preclinical Alzheimer disease cases. The present work explores GM hippocampal and amygdala
Zanchi D, Giannakopoulos P, Borgwardt S, Rodriguez C, Haller S.   +4 more
europepmc   +7 more sources

Postoperative neurocognitive disorders [PDF]

Korean Journal of Anesthesiology, 2021
A decline in cognitive function is a frequent complication of major surgery. Postoperative cognitive impairments have generally been divided into short- (postoperative delirium) and long-term disturbances (postoperative cognitive dysfunction [POCD ...
Setayesh Reza Tasbihgou, Anthony Ray Absalom   +1 more
doaj   +1 more source