Regional hyperperfusion in older adults with objectively-defined subtle cognitive decline [PDF]
Journal of Cerebral Blood Flow and Metabolism, 2021 Although cerebral blood flow (CBF) alterations are associated with Alzheimer’s disease (AD), CBF patterns across prodromal stages of AD remain unclear. Therefore, we investigated patterns of regional CBF in 162 Alzheimer’s Disease Neuroimaging Initiative participants characterized as cognitively unimpaired (CU; n = 80), objectively-defined subtle ...
Kelsey R Thomas +2 more
exaly +7 more sources
EClinicalMedicine, 2023 Summary: Background: High antiretroviral therapy (ART) coverage and viral suppression among people with HIV (PWH) in Australia provide a unique context to study individual cognitive trajectories, cognitive aging and factors associated with longitudinal ...
Htein Linn Aung +6 more
doaj +5 more sources
Using Neuropsychological Process Scores to Identify Subtle Cognitive Decline and Predict Progression to Mild Cognitive Impairment [PDF]
Journal of Alzheimer's Disease, 2018 Background: We previously operationally-defined subtle cognitive decline (SCD) in preclinical Alzheimer’s disease (AD) using total scores on neuropsychological (NP) tests. NP process scores (i.e., provide information about how a total NP score was achieved) may be a useful tool for identifying early cognitive ...
Kelsey R Thomas +2 more
exaly +7 more sources
Elevated plasma neurofilament light predicts a faster rate of cognitive decline over 5 years in participants with objectively‐defined subtle cognitive decline and MCI [PDF]
Alzheimer's and Dementia, 2021 AbstractIntroductionNeurofilament light (NFL) reflects neuroaxonal damage and is implicated in mild cognitive impairment (MCI) and Alzheimer's disease (AD). Little is known about NFL in pre‐MCI stages, such as in individuals with objectively‐defined subtle cognitive decline (Obj‐SCD).MethodsTwo hundred ninety‐four participants from the Alzheimer's ...
Katherine J Bangen +2 more
exaly +6 more sources
Personality-Related Determinants of Subtle Cognitive Decline in Old Age: A Population-Based Study [PDF]
Dementia and Geriatric Cognitive Disorders Extra, 2016 Background/Aims: Recent studies of cases with mild cognitive impairment (MCI) suggested that besides Alzheimer disease (AD)-related biomarkers, some personality dimensions are associated with progression to AD.
Cristelle Rodriguez +7 more
doaj +4 more sources
Using the Montreal cognitive assessment to identify individuals with subtle cognitive decline. [PDF]
Neuropsychology, 2022 Dementia is a devastating neurological disease that may be better managed if diagnosed earlier when subclinical neurodegenerative changes are already present, including subtle cognitive decline and mild cognitive impairment. In this study, we used item-level performance on the Montreal Cognitive Assessment (MoCA) to identify individuals with subtle ...
Cersonsky TEK +7 more
europepmc +3 more sources
Cognitive Heterogeneity and Risk of Progression in Data-Driven Subtle Cognitive Decline Phenotypes. [PDF]
J Alzheimers Dis, 2022 Background: There is increasing recognition of cognitive and pathological heterogeneity in early-stage Alzheimer’s disease and other dementias. Data-driven approaches have demonstrated cognitive heterogeneity in those with mild cognitive impairment (MCI), but few studies have examined this heterogeneity and its association with progression to MCI ...
Thomas KR +7 more
europepmc +5 more sources
Altered functional connectivity pattern of hippocampal subfields in individuals with objectively‐defined subtle cognitive decline and its association with cognition and cerebrospinal fluid biomarkers [PDF]
European Journal of Neuroscience, 2022 Tiantian Qiu +2 more
exaly +2 more sources
Associations of plasma phosphorylated tau181 and neurofilament light chain with brain amyloid burden and cognition in objectively defined subtle cognitive decline patients [PDF]
CNS Neuroscience and Therapeutics, 2022 Yuehua Li, Fang Xie, Qihao Guo
exaly +2 more sources
Analysis of the relationship between blood pressure variability and subtle cognitive decline in older adults. [PDF]
World J Psychiatry, 2023 BACKGROUND Blood pressure variability (BPV) has been shown to be related to mild cognitive impairment and Alzheimer's disease in a number of studies. However, the relationship between BPV and subtle cognitive decline (SCD) has received minimal attention in this field of research to date and has rarely been reported. AIM To
Guo HF, Wu Y, Li J, Pan FF.
europepmc +3 more sources