Results 51 to 60 of about 2,709,938 (252)

Symposium 13: Prediabetes and brain

Revista de la Sociedad Argentina de Diabetes, 2022
Prediabetes is a serious but reversible problem characterized by hyperglycemia and insulin resistance1. Decline in β-cell function was seen in prediabetes due to metabolic and epigenetic changes and alterations at the level of its cellular biology ...
Gustavo Díaz
doaj   +1 more source

Management of patients with pre-dementia cognitive impairment

Российский журнал гериатрической медицины
Cognitive disorders are one of the most significant problems for elderly and senile people. Particular attention should be paid to the diagnosis of early pre-dementia stages of cognitive impairment: subjective and subtle cognitive decline and mild ...
N. N. Koberskaya
doaj   +1 more source

Low thalamic activity during a digit-symbol substitution task is associated with symptoms of subjective cognitive decline

Frontiers in Psychiatry, 2023
IntroductionSubjective cognitive decline (SCD) may represent the earliest preclinical stage of Alzheimer's Disease (AD) for some older adults. However, the underlying neurobiology of SCD is not completely understood.
Akiko Mizuno, Helmet Talib Karim, Helmet Talib Karim, Maria J. Ly, Maria J. Ly, Brian J. Lopresti, Ann D. Cohen, Areej A. Ali, Chester A. Mathis, William E. Klunk, Howard J. Aizenstein, Howard J. Aizenstein, Beth E. Snitz   +12 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Effects of non-pharmacological or pharmacological interventions to promote cognition and brain plasticity in aging individuals

Frontiers in Systems Neuroscience, 2014
Brain aging and aging-related neurodegenerative disorders are major health challenges faced by modern societies. Brain aging is associated with cognitive and functional decline and represents the favourable background for the onset and development of ...
Valentina ePieramico, Roberto eEsposito, Stefano eCesinaro, Valerio eFrazzini, Stefano Luca Sensi, Stefano Luca Sensi, Stefano Luca Sensi   +6 more
doaj   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Listening Effort and Cognitive Decline: An Exploratory Study Using Pupillometry [PDF]

, 2019
For today’s ageing population, hearing loss and dementia prevalence are expected to increase. Recent research suggests that hearing loss is the highest modifiable risk factor for dementia in midlife.
Patou, François, Waldemar, Gunhild, Maier, Anja, Feldman, Alix   +3 more
core   +3 more sources

Conventional clock drawing tests have low to moderate reliability and validity for detecting subtle cognitive impairments in community-dwelling older adults

Frontiers in Aging Neuroscience, 2023
BackgroundEarly identification of subtle cognitive decline in community-dwelling older adults is critical, as mild cognitive impairment contributes to disability and can be a precursor to dementia.
Kristen E. Kehl-Floberg, Timothy S. Marks, Dorothy F. Edwards, Dorothy F. Edwards, Gordon M. Giles   +4 more
doaj   +1 more source

Cognitive decline in people with mild dementia during COVID-19 pandemic

, 2023
reservedBackground: restrictive measures adopted to prevent the spread of COVID-19 infection resulted in pre-existing neuropsychiatric symptoms and cognitive worsening in people with MCI and dementia in the first year of pandemic.
MARIOTTI, MARTINA
core  

Self‐Regulated Learning Meets AI: Reinterpreting Self‐Regulation, Co‐Regulation, and Socially Shared Regulation in Human–AI Interaction

New Directions for Adult and Continuing Education, EarlyView.
ABSTRACT Advancing artificial intelligence (AI) has transformed learning and work, yet higher education and professional development programs have not systematically equipped learners for AI‐prevalent environments. This lack of preparation creates uncertainty regarding control, responsibility, trust, and accountability.
Moon‐Heum Cho, Jerusalem Merkebu
wiley   +1 more source