Results 51 to 60 of about 43,561 (219)

Objective Criteria for Subtle Cognitive Decline in Aging and Preclinical AD: A Systematic Review [PDF]

Alzheimers Dement
AbstractBackgroundThe field of Alzheimer’s disease and related dementias (ADRD) has continued to move toward earlier detection. Within the 2018 NIA‐AA AD Research Framework, clinical stage 2 recognizes that someone can be cognitively unimpaired but still experience “subtle cognitive decline” as measured by subjective report or evidence of objective ...
Thomas K, Edmonds E.
europepmc   +2 more sources

Normal‐Appearing White Matter Injury Mediates Chronic Deep Venous Hypoxia and Disease Progression in Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To explore how cerebral hypoxia and Normal‐Appearing White Matter (NAWM) integrity affect MS lesion burden and clinical course. Methods Seventy‐nine MS patients, including 13 clinically isolated syndrome (CIS) patients and 66 relapsing–remitting multiple sclerosis (RRMS) patients, and 44 healthy controls (HCs) were recruited from ...
Xinli Wang, Huiying Wang, Zhizheng Zhuo, Ai Guo, Ke Lv, Decai Tian, Chao Chai, Yunyun Duan, Shuang Xia   +8 more
wiley   +1 more source

Poor decision making is a consequence of cognitive decline among older persons without Alzheimer's disease or mild cognitive impairment. [PDF]

PLoS ONE, 2012
Decision making is an important determinant of health and well-being across the lifespan but is critical in aging, when many influential decisions are made just as cognitive function declines.
Patricia A Boyle, Lei Yu, Robert S Wilson, Keith Gamble, Aron S Buchman, David A Bennett   +5 more
doaj   +1 more source

A Depolarizing Leak in Sodium Bicarbonate Cotransporter NBCe1 Causes Brain Edema

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives SLC4A4 encodes electrogenic sodium bicarbonate cotransporter NBCe1, prominently expressed in kidney and brain. Recessive loss‐of‐function variants in SLC4A4 cause proximal renal tubular acidosis, no brain edema. In the brain, NBCe1 is expressed by astrocytes, where it regulates pH and mediates astrocyte volume changes.
Quinty Bisseling, Mark D. Parker, Sven Kerst, Richard A. Pasternack, Jacob Tondreau, Marjolein Breur, Gemma M. van Rooijen‐van Leeuwen, Davide Tonduti, Ettore Salsano, Alejandra Darling, Joanna A. E. van Wijk, Susanna Törnroth‐Horsefield, Marianna Bugiani, Petra J. W. Pouwels, Quinten Waisfisz, Marjo S. van der Knaap, Rogier Min   +16 more
wiley   +1 more source

Neuropsychological decrements in midlife type-2 diabetes are not associated with peripheral NLRP3 inflammasome responsiveness

Frontiers in Immunology, 2022
Midlife Type 2 Diabetes Mellitus (T2DM) is associated with an increased risk of Alzheimer Disease (AD) in later life, with altered inflammatory responses postulated as key pathological drivers.
Adam H. Dyer, Adam H. Dyer, Adam H. Dyer, Adam H. Dyer, Isabella Batten, Isabella Batten, Conor Reddy, Conor Reddy, Liam Townsend, Conor P. Woods, Desmond O’Neill, Desmond O’Neill, James Gibney, Sean P. Kennelly, Sean P. Kennelly, Nollaig M. Bourke, Nollaig M. Bourke   +16 more
doaj   +1 more source

[18F]Fluorodeprenyl‐D2 PET as a Tool to Monitor Disease Activity in GAD65‐Ab Autoimmune Encephalitis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To evaluate [18F]fluorodeprenyl‐D2 ([18F]F‐DED) positron‐emission tomography (PET) imaging as a biomarker of disease activity in autoimmune encephalitis (AIE) associated with glutamic acid decarboxylase 65 (GAD65) antibodies. Methods [18F]F‐DED PET was performed in 25 GAD65‐AIE patients and 8 controls using dynamic (0–60 min) and ...
Julia S. Dorneich, Jonathan A. Gernert, Hanna Zimmermann, Lisa Tagnin, Marianthi Zeinaki, Laura Sanzo, Letizia Vogler, Elisabeth Kaufmann, Justina Dargvainiene, Frank Leypoldt, Gérard N. Bischof, Robert Perneczky, Boris‐Stephan Rauchmann, Simon Lindner, Günter U. Höglinger, Rudolf A. Werner, Martin Kerschensteiner, Tania Kümpfel, Matthias Brendel, Franziska S. Thaler   +19 more
wiley   +1 more source

Cognitive performance before and after the onset of subjective cognitive decline in old age

Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, 2015
Background Our objectives were (1) to test the association between the report of subjective cognitive decline (SCD) and prospective objective cognitive performance in high age individuals and (2) to study the course of longitudinal cognitive performance ...
Alexander Koppara, Michael Wagner, Carolin Lange, Annette Ernst, Birgitt Wiese, Hans‐Helmut König, Christian Brettschneider, Steffi Riedel‐Heller, Melanie Luppa, Siegfried Weyerer, Jochen Werle, Horst Bickel, Edelgard Mösch, Michael Pentzek, Angela Fuchs, Steffen Wolfsgruber, André Beauducel, Martin Scherer, Wolfgang Maier, Frank Jessen   +19 more
doaj   +1 more source

Cognitive impairment and dementia in Parkinson's disease

Neurobiology of Disease, 2012
Relatively subtle cognitive disturbances may be present from the initial stages of Parkinson's disease (PD) that progress in many patients to a more severe cognitive impairment and dementia.
Javier Pagonabarraga, Jaime Kulisevsky
doaj   +1 more source

Developing Early Markers of Cognitive Decline and Dementia Derived From Survey Response Behaviors: Protocol for Analyses of Preexisting Large-scale Longitudinal Data

JMIR Research Protocols, 2023
BackgroundAccumulating evidence shows that subtle alterations in daily functioning are among the earliest and strongest signals that predict cognitive decline and dementia.
Haomiao Jin, Doerte U Junghaenel, Bart Orriens, Pey-Jiuan Lee, Stefan Schneider   +4 more
doaj   +1 more source

Comparing the Effect of Semi‐Immersive Virtual Reality, Computerized Cognitive Training, and Traditional Rehabilitation on Cognitive Function in Multiple Sclerosis: A Randomized Clinical Trial

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Cognitive impairment is a common non‐motor symptom in Multiple Sclerosis (MS), negatively affecting autonomy and Quality of Life (QoL). Innovative rehabilitation strategies, such as semi‐immersive virtual reality (VR) and computerized cognitive training (CCT), may offer advantages over traditional cognitive rehabilitation (TCR ...
Maria Grazia Maggio, Desiree Latella, Lilla Bonanno, Paulo Cezar Rocha dos Santos, Marcos Maldonado‐Díaz, Meir Plotnik, Rosaria De Luca, Angelo Quartarone, Rocco Salvatore Calabrò   +8 more
wiley   +1 more source