Results 71 to 80 of about 2,709,938 (252)

Sex‐Stratified Association of Regional Dopamine Transporter Binding With Disease Progression in Amyotrophic Lateral Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To clarify the clinical relevance of dopamine transporter single‐photon emission computed tomography (DAT‐SPECT) abnormalities in amyotrophic lateral sclerosis (ALS), with a prespecified focus on sex‐stratified associations with disease progression and short‐term prognosis.
Tomoya Kawazoe, Keizo Sugaya, Kentaro Hayashi, Keiko Hino, Yasuhiro Nakata, Kota Bokuda, Toshio Shimizu, Kazushi Takahashi   +7 more
wiley   +1 more source

Neuropsychological decrements in midlife type-2 diabetes are not associated with peripheral NLRP3 inflammasome responsiveness

Frontiers in Immunology, 2022
Midlife Type 2 Diabetes Mellitus (T2DM) is associated with an increased risk of Alzheimer Disease (AD) in later life, with altered inflammatory responses postulated as key pathological drivers.
Adam H. Dyer, Adam H. Dyer, Adam H. Dyer, Adam H. Dyer, Isabella Batten, Isabella Batten, Conor Reddy, Conor Reddy, Liam Townsend, Conor P. Woods, Desmond O’Neill, Desmond O’Neill, James Gibney, Sean P. Kennelly, Sean P. Kennelly, Nollaig M. Bourke, Nollaig M. Bourke   +16 more
doaj   +1 more source

Persistent cognitive decline in older hospitalized patients in Taiwan

, 2011
Aim. This paper is a report of a study conducted to determine the prevalence and predictors of persistent and transient cognitive decline in older hospitalized patients over 6 months after hospital discharge. Background. Cognitive decline occurs in 16–35·
Chen, Cheryl Chia-Hui; Chang, Yue-Cune; Huang, Guan-Hua; Peng, Jui-Hua; Tseng, Chien-Ning
core   +1 more source

Electroencephalographic Normalization as a Biomarker of Clinical Recovery in Down Syndrome Regression Disorder

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Down syndrome regression disorder is a syndrome characterized by subacute loss of cognitive, behavioral, and functional abilities in individuals with Down syndrome. Electroencephalography abnormalities are frequently observed during evaluation, but it remains unclear whether these findings represent a dynamic marker of disease ...
Jonathan D. Santoro, Mackenzie Silverman, Maeve C. Lucas, Mariam M. Yousuf, Samuel T. Otey, Stella V. Gray, Brittany Jordan, Madeline D. Kahan, Latanya D. Agurs, Michelle Van Hirtum Das, Deborah Holder, Devin King, Eileen A. Quinn, Ryan Kammeyer, Michael S. Rafii   +14 more
wiley   +1 more source

Cognitive impairment and dementia in Parkinson's disease

Neurobiology of Disease, 2012
Relatively subtle cognitive disturbances may be present from the initial stages of Parkinson's disease (PD) that progress in many patients to a more severe cognitive impairment and dementia.
Javier Pagonabarraga, Jaime Kulisevsky
doaj   +1 more source

Association between gait features assessed by artificial intelligent system and cognitive function decline in patients with silent cerebrovascular disease: study protocol of a multicenter prospective cohort study (ACCURATE-2)

BMC Neurology, 2022
Background Gait disturbances may appear prior to cognitive dysfunction in the early stage of silent cerebrovascular disease (SCD). Subtle changes in gait characteristics may provide an early warning of later cognitive decline.
Yan-min Tang, Bei-ni Fei, Xin Li, Jin Zhao, Wei Zhang, Guo-you Qin, Min Hu, Jing Ding, Xin Wang   +8 more
doaj   +1 more source

Developing Early Markers of Cognitive Decline and Dementia Derived From Survey Response Behaviors: Protocol for Analyses of Preexisting Large-scale Longitudinal Data

JMIR Research Protocols, 2023
BackgroundAccumulating evidence shows that subtle alterations in daily functioning are among the earliest and strongest signals that predict cognitive decline and dementia.
Haomiao Jin, Doerte U Junghaenel, Bart Orriens, Pey-Jiuan Lee, Stefan Schneider   +4 more
doaj   +1 more source

Homocysteine and cognitive decline in healthy elderly

, 2001
This article is not available through ChesterRep.Serum homocysteine is increased, and correlates inversely with cognitive scores, in Alzheimer's disease (AD), vascular dementia and "age-associated memory impairment".
Hudson, Peter R., Williams, John H. H., Hughes, Alan, Davies, Gareth K., Wilkinson, Clare, McCaddon, Andrew   +5 more
core   +1 more source

Paramagnetic Rim Lesions and Choroid Plexus Volume at Diagnosis Are Associated With Cognitive Progression Independent of Relapse and MRI Activity in Early Relapsing–Remitting Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Paramagnetic rim lesions (PRLs) and choroid plexus (CP) enlargement reflect smoldering inflammation in multiple sclerosis. Their role in cognitive progression remains unexplored. Eighty‐seven early relapsing–remitting MS patients were enrolled at diagnosis and followed longitudinally.
Stefano Ziccardi, Damiano Marastoni, Agnese Tamanti, Pietro Biasi, Valentina Visani, Annalisa Colombi, Tom A. Fuchs, Monica Sicchieri, Chiara Eccher, Francesco Guarnaccia, Milena Calderone, Valentina Camera, Francesca Benedetta Pizzini, Roberta Magliozzi, Marco Castellaro, Massimiliano Calabrese   +15 more
wiley   +1 more source

Biomarker-Based Signature of Alzheimer’s Disease in Pre-MCI Individuals

Brain Sciences, 2019
Alzheimer’s disease (AD) pathology begins decades before the onset of clinical symptoms. It is recognized as a clinicobiological entity, being detectable in vivo independently of the clinical stage by means of pathophysiological biomarkers ...
Elena Chipi, Nicola Salvadori, Lucia Farotti, Lucilla Parnetti   +3 more
doaj   +1 more source