Results 91 to 100 of about 1,160,550 (308)

Subtype-WGME

<p>Subtype-WGME uses genome-wide gene expression, miRNA, copy number and mutation data from PCAWG as input. It is an auto-encoder (VAE) framework using MLP-Mixer as the backbone encoder.
Liang Zhao, Yang Yang, Zhe Wang
core   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

MOLECULAR EPIDEMIOLOGY FEATURES OF HEPATITIS C VIRUS ISOLATES FROM DIFFERENT REGIONS OF THE REPUBLIC SAKHA (YAKUTIA)

Инфекция и иммунитет, 2016
According to WHO data about 3% of population are infected by hepatitic C virus (HCV) worldwide. Chronic hepatitis C is the leading cause of cirrhosis and hepatocellular carcinoma, thus it becoming one of the global public health problems.
A. V. Semenov, Ju. V. Ostankova, V. V. Gerasimova, M. A. Bichurina, A. V. Kozlov, S. L. Mukomolov, Areg A. Totolian   +6 more
doaj   +1 more source

Efficient recursive subtyping

Mathematical Structures in Computer Science, 1992
Subtyping in the presence of recursive types for the λ-calculus was studied by Amadio and Cardelli in 1991 (Amadio and Cardelli 1991). In that paper they showed that the problem of deciding whether one recursive type is a subtype of another is decidable in exponential time. In this paper we give an 0(n2) algorithm.
Schwartzbach, Michael Ignatieff, Kozen, Dexter, Palsberg, Jens   +2 more
openaire   +7 more sources

D-Dimers Predict Stroke Subtype when Assessed Early [PDF]

, 2009
Early classification of ischemic stroke subtype is important for secondary stroke prevention and may guide further ...
Arnold, Marcel, Kohler, Hans-Peter, Meier, Niklaus, Nedeltchev, Krassen, Isenegger, Jörg, Alberio, Lorenzo, Fischer, Urs, Gralla, Jan, Mattle, Heinrich, Lämmle, Bernhard, Isenegger J, Fischer U, Arnold M, Alberio L, Lämmle B, Gralla J, Nedeltchev K, Kohler HP, Mattle HP, Meier N, Krassen Nedeltchev, Urs Fischer, Lorenzo Alberio, Hans-Peter Kohler, Bernhard Lämmle, Niklaus Meier, Jörg Isenegger, Heinrich P. Mattle, Jan Gralla, Marcel Arnold   +29 more
core   +2 more sources

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

Read numbers and subtype frequencies.

, 2014
a) Undetermined in regard of sample.b) Undetermined in regard of subtype.nd = not done.na = not applicable.Read numbers and subtype frequencies.
Enkelejda Miho (654050), Sai T. Reddy (167874), Alexandra Trkola (51210), Thomas Liechti (654049), Osvaldo Zagordi (304585), Huldrych F. Günthard (173082), Merle Schanz (173073), Michael Huber (274369)   +7 more
core   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Characteristics of Subtype and Molecular Transmission Networks among Newly Diagnosed HIV-1 Infections in Patients Residing in Taiyuan City, Shanxi Province, China, from 2021 to 2023

Viruses
The HIV-1 pandemic, spanning four decades, presents a significant challenge to global public health. This study aimed to understand the molecular transmission characteristics of newly reported HIV infections in Taiyuan, Shanxi Province, China, to analyze
Ruihong Gao, Wentong Li, Jihong Xu, Jiane Guo, Rui Wang, Shuting Zhang, Xiaonan Zheng, Jitao Wang   +7 more
doaj   +1 more source

Polymerase chain reaction-based subtype diversity of Blastocystis species isolates obtained from hospitalized patients with blastocystosis

Archives of the Balkan Medical Union, 2020
Introduction. Blastocystis sp. is a common protozoan parasite that colonizes the intestinal tract of humans and animals and in humans nine subtypes have been described so far.
Martin P. LALEV, Vladislav M. NANKOV, Ludmil S. STOYANOV, Ivelin A. ANGELOV   +3 more
doaj   +1 more source