Results 81 to 90 of about 1,350,829 (302)
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
CosmeticsAcne, a commonly treated skin disease, requires control of one’s daily routine for an optimal outcome. As skincare products continue to advance, and with the introduction of dermocosmetics (active cosmetics, functional cosmetics, cosmeceuticals), it is ...
Hei Sung Kim +5 more
doaj +1 more source
Clinical Ophthalmology, 2023 Hideaki Fujita, Tomohiro Ueno, Shuji Suzuki, Kazuhiro Harada, Tomoko Tsukahara-Kawamura, Hiroaki Ozaki, Eiichi Uchio Department of Ophthalmology, Fukuoka University School of Medicine, Fukuoka, JapanCorrespondence: Eiichi Uchio, Department of ...
Fujita H +6 more
doaj
On the properties of contact binary stars
, 2004 A catalogue of light curve solutions of contact binary stars has been compiled. It contains the results of 159 light curve solutions. Properties of contact binary stars were studied by using the catalogue data. As it is well known since Lucy's (1968a,b)
Binnendijk +22 more
core +1 more source
Decompositions of a polygon into centrally symmetric pieces [PDF]
, 2015 In this paper we deal with edge-to-edge, irreducible decompositions of a centrally symmetric convex $(2k)$-gon into centrally symmetric convex pieces. We prove an upper bound on the number of these decompositions for any value of $k$, and characterize ...
Frittmann, Júlia, Lángi, Zsolt
core +2 more sources
Mathematical Structures in Computer Science, 1992 Subtyping in the presence of recursive types for the λ-calculus was studied by Amadio and Cardelli in 1991 (Amadio and Cardelli 1991). In that paper they showed that the problem of deciding whether one recursive type is a subtype of another is decidable in exponential time. In this paper we give an 0(n2) algorithm.
Schwartzbach, Michael Ignatieff +2 more
openaire +4 more sources
Molecular Oncology, EarlyView.Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff +11 more
wiley +1 more source
Expanded Indications of Molecular-Targeted Drugs in Perioperative Therapy of Breast Cancer
Tokyo Women's Medical University JournalIn recent years, numerous molecular-targeted drugs have become available for the perioperative therapy of breast cancer, bringing about a revolution in breast cancer treatment.
Eiichiro Noguchi, Sadako Akashi-Tanaka
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Molecular Oncology, EarlyView.Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon +9 more
wiley +1 more source