Results 81 to 90 of about 1,067,207 (315)

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

An outbreak of HIV-1 subtype G among Italian injecting drug users

, 2007
We describe an outbreak of subtype G among injecting drug users (IDU) in northern Italy newly infected with HIV. We analysed pol gene sequences from samples of 139 individuals from different risk groups. Non-B subtypes were more frequently detected among
T. De Oliveira, M. Ciccozzi, A. Sinicco, De Luca, Andrea, G. Rezza, C. Balotta, M. Salemi, A. De Luca, S. Montieri, M. Dorrucci, M. Giuliani   +10 more
core   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

D-Dimers Predict Stroke Subtype when Assessed Early [PDF]

, 2010
Early classification of ischemic stroke subtype is important for secondary stroke prevention and may guide further ...
Arnold, Marcel, Kohler, Hans-Peter, Meier, Niklaus, Nedeltchev, Krassen, Isenegger, Jörg, Alberio, Lorenzo, Fischer, Urs, Gralla, Jan, Mattle, Heinrich, Lämmle, Bernhard   +9 more
core   +1 more source

HIV subtype distribution.

, 2023
A) Frequency of HIV-1 subtype in all samples, B) HIV-1 subtype distribution in ART-naïve and ART-experienced group. Each bar represented the subtype frequency in each group.
Dilsha Siddiqui (16877717), Fatima Mir (8967854), Sofia Furqan (16877726), Mahnoor Javaid (16877723), Ayesha Iftikhar (11559090), Nida Farooqui (12524843), Syed Hani Abidi (11361852), Faisal Sultan (10996620), Sharaf Ali Shah (14380838), Syed Faisal Mahmood (11287566), Uzma Badar (16877720)   +10 more
core   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Swine influenza A virus subtype H1N2 in Sweden [PDF]

, 2014
The influenza A virus subtypes H1N1, H1N2 and H3N2 are prevalent in pig populations worldwide. All scientific data point towards swine as the key host species for new human influenza pandemics, which have been suggested to evolve in pigs from viral genes
Metreveli, Giorgi
core  

Addressing the Unmet Need in Acne Management: A Novel Dermocosmetics Guideline Tailored to Asian Patient Subgroups

Cosmetics
Acne, a commonly treated skin disease, requires control of one’s daily routine for an optimal outcome. As skincare products continue to advance, and with the introduction of dermocosmetics (active cosmetics, functional cosmetics, cosmeceuticals), it is ...
Hei Sung Kim, Joo Yeon Ko, Dong Hye Suh, Hwa Jung Ryu, Eunsun Baek, Soyun Cho   +5 more
doaj   +1 more source

Classification of Subtypes of Vernal Keratoconjunctivitis by Cluster Analysis Based on Clinical Features

Clinical Ophthalmology, 2023
Hideaki Fujita, Tomohiro Ueno, Shuji Suzuki, Kazuhiro Harada, Tomoko Tsukahara-Kawamura, Hiroaki Ozaki, Eiichi Uchio Department of Ophthalmology, Fukuoka University School of Medicine, Fukuoka, JapanCorrespondence: Eiichi Uchio, Department of ...
Fujita H, Ueno T, Suzuki S, Harada K, Tsukahara-Kawamura T, Ozaki H, Uchio E   +6 more
doaj  

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source