Results 71 to 80 of about 1,350,829 (302)

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Prevalence and transmission of HIV-1 drug resistance mutations among patients with treatment failure and newly diagnosed people in Liangshan Prefecture, China, in 2021–2023

Frontiers in Public Health
IntroductionDespite expanded antiretroviral therapy (ART) in China, HIV transmission persists. Liangshan Prefecture is one of the areas in China most severely affected by HIV, with high levels of drug resistance.
Rong Pei, Rong Pei, Yulian Zhang, Chunnong Jike, Gang Yu, Ling Su, Ju Wang, Lin Xiao, Yubing Wang, Maogang Shen, Jiayi Liao, Yifei Zheng, Joris Hemelaar   +12 more
doaj   +1 more source

Single‐Cell RNA‐seq Reveals a Developmental Hierarchy Super‐Imposed Over Subclonal Evolution in the Cellular Ecosystem of Prostate Cancer

Advanced Science, 2022
Prostate cancer (PCa) is a complex disease. An ongoing accumulation of mutations results in increased genetic diversity, with the tumor acquiring distinct subclones. However, non‐genetic intra‐tumoral heterogeneity, the cellular differentiation state and
Guangzhe Ge, Yang Han, Jianye Zhang, Xinxin Li, Xiaodan Liu, Yanqing Gong, Zhentao Lei, Jie Wang, Weijie Zhu, Yangyang Xu, Yiji Peng, Jianhua Deng, Bao Zhang, Xuesong Li, Liqun Zhou, Huiying He, Weimin Ci   +16 more
doaj   +1 more source

On the origin of W UMa type Contact binaries - a new method for computation of initial masses

, 2013
W UMa type binaries have two defining characteristics. These are (i) the effective temperatures of both components are very similar, and (ii) the secondary (currently less massive) component is overluminous for its current mass. We consider the latter to
Dogan, Tuncay, Yildiz, Mutlu
core   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

Studying luminal A and B subtypes of breast cancer under paracrine secretion of fibro- blasts [PDF]

BioImpacts
Introduction: Understanding the key role of the tumor microenvironment in specifying molecular markers of breast cancer subtypes is of a high importance in diagnosis and treatment. Therefore, the possibility of interconversion of luminal states and their
Nazila Jalilzadeh, Neda Barzgar Barough, Mehrdad Karami, Amir Baghbanzadeh, Kobra Velaei   +4 more
doaj   +1 more source

Stellar Rotation in Young Clusters. I. Evolution of Projected Rotational Velocity Distributions

, 2005
Open clusters offer us the means to study stellar properties in samples with well-defined ages and initial chemical composition. Here we present a survey of projected rotational velocities for a large sample of mainly B-type stars in young clusters to ...
Ardeberg A., Balona L. A., Balona L. A., Bertelli G., Boden E., Brown A. G. A., D. R. Gies, Dachs J., Fabregat J., Feinstein A., Hoag A. A., Howarth I. D., Loden L. O., Loktin A. V., Maeder A., Mermilliod J.-C., Meynet G., Meynet G., Moffat A. F. J., Ogura K., Oosterhoff P. T., Pols O. R., Purgathofer A., Schaller G., Van Bever J., van Schewick H., Vogt N., W. Huang   +27 more
core   +1 more source

Drug resistance and viral tropism in HIV-1 subtype C-infected patients in KwaZulu-Natal, South Africa: implications for future treatment options [PDF]

, 2011
Article approval pendingDrug resistance poses a significant challenge for the successful application of highly active antiretroviral therapy (HAART) globally. Furthermore, emergence of HIV-1 isolates that preferentially use CXCR4 as a coreceptor for cell
Ashika Singh, Bjorndal, Brenner, Briggs, Briz, Cann, Cecilia, Cilliers, Coakley, Coetzer, Connor, Cozzi-Lepri, Daniel R. Kuritzkes, Elizabeth D. Anton, Fouchier, Fouchier, Furtado, Henry Sunpath, Hosseinipour, Hunt, Irlbeck, Jacqueline D. Reeves, Johnston, Kantor, Keshni Hiramen, Kuiken, Loemba, Low, Marconi, Nagavelli Padayachi, Ndungu, Novitsky, Reeves, Richard Murphy, Rizzuto, Scarlatti, Singh, Tamura, Taryn N. Green, Taylor, Thumbi Ndung'u, Tobin, Trinh, Tscherning, Wallis, Westby, Whitcomb, Wu, Yolanda Lie   +48 more
core   +2 more sources

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Comprehensive Characterization of the Transmitted/Founder env Genes From a Single MSM Cohort in China [PDF]

, 2015
Background: The men having sex with men (MSM) population has become one of the major risk groups for HIV-1 infection in China. However, the epidemiological patterns, function of the env genes, and autologous and heterologous neutralization activity in ...
Cai, F, Chen, Y, Gao, F, Huang, X, Jiang, C, Li, N, Meng, Z, Montefiori, DC, Vandergrift, N, Wu, H, Xin, R, Xu, X, Zhang, T, Zhang, X   +13 more
core   +1 more source