Results 71 to 80 of about 1,067,207 (315)
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
Characterizing the emergence and persistence of drug resistant mutations in HIV-1 subtype C infections using 454 ultra deep pyrosequencing. [PDF]
, 2013 BACKGROUND: The role of HIV-1 RNA in the emergence of resistance to antiretroviral therapies (ARTs) is well documented while less is known about the role of historical viruses stored in the proviral DNA. The primary focus of this work was to characterize
Grace P McCormack +21 more
core +1 more source
COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells
Molecular Oncology, EarlyView.This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos +6 more
wiley +1 more source
Frontiers in Public HealthIntroductionDespite expanded antiretroviral therapy (ART) in China, HIV transmission persists. Liangshan Prefecture is one of the areas in China most severely affected by HIV, with high levels of drug resistance.
Rong Pei +12 more
doaj +1 more source
Advanced Science, 2022 Prostate cancer (PCa) is a complex disease. An ongoing accumulation of mutations results in increased genetic diversity, with the tumor acquiring distinct subclones. However, non‐genetic intra‐tumoral heterogeneity, the cellular differentiation state and
Guangzhe Ge +16 more
doaj +1 more source
Game semantics and subtyping [PDF]
Proceedings Fifteenth Annual IEEE Symposium on Logic in Computer Science (Cat. No.99CB36332), 2002 While game semantics has been remarkably successful at modelling, often in a fully abstract manner a wide range of features of programming languages, there has to date been no attempt at applying it to subtyping. We show how the simple device of explicitly introducing error values in the syntax of the calculus leads to a notion of subtyping for game ...
openaire +2 more sources
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
Comparative analysis of spatial and transform domain methods for meningioma subtype classification [PDF]
, 2010 Pattern recognition in histopathological image analysis requires new techniques and methods. Various techniques have been presented and some state of the art techniques have been applied to complex textural data in histological images.
Qureshi, Hammad A. +1 more
core
The association between children's ADHD subtype and parenting stress and parental symptoms
, 2011 100學年度研究獎補助論文Objective. To investigate the association between two attention deficit/hyperactivity disorder (ADHD) subtypes—combined and inattentive subtypes—and parental stress in a Taiwanese population. Method.
Tzang, Ruu-Fen +1 more
core +1 more source
Studying luminal A and B subtypes of breast cancer under paracrine secretion of fibro- blasts [PDF]
BioImpactsIntroduction: Understanding the key role of the tumor microenvironment in specifying molecular markers of breast cancer subtypes is of a high importance in diagnosis and treatment. Therefore, the possibility of interconversion of luminal states and their
Nazila Jalilzadeh +4 more
doaj +1 more source