Results 131 to 140 of about 1,160,550 (308)

Evaluating the neutralizing antibody response to HIV-1 membrane proximal external regional; Implications for vaccine design [PDF]

, 2014
Includes bibliographical references.Inducing broadly neutralizing antibodies targeting the HIV-1 envelope is thought to be crucial for developing an effective vaccine.
Jacob, Rajesh Abraham
core   +1 more source

Predictive and prognostic biomarkers of Bacillus Calmette‐Guérin therapy failure in bladder cancer patients: A systematic review

Molecular Oncology, EarlyView.
High‐risk bladder cancer is typically treated with Bacillus Calmette‐Guérin (BCG), but 30–40% of patients relapse. No FDA‐ or CE‐approved biomarkers currently predict or prognosticate BCG failure. We systematically reviewed the literature and identified 72 eligible studies, revealing several promising biomarkers associated with BCG treatment response ...
Rui Ribeiro‐Pereira, Ana Teixeira‐Marques, Rui Freitas, João A Carvalho, Sara Monteiro‐Reis, Giorgio I. Russo, Rui Henrique, Carmen Jerónimo   +7 more
wiley   +1 more source

NAPRT loss promotes lung tumor initiation and growth through AKT signaling independently of NAD+ biosynthesis

Molecular Oncology, EarlyView.
Loss of NAPRT promotes lung tumor initiation and growth through a noncanonical mechanism, independent of its role in NAD+ biosynthesis. Mechanistically, NAPRT depletion activates the mTORC2‐driven AKT/β‐catenin signaling axis to enhance clonogenic and invasive phenotypes. Furthermore, lung‐specific Naprt deletion significantly increases tumor burden in
Myung Joon Oh, Ji Yun Jang, Yoon Jeon, Gi‐Cheon Kim, Hwanho Lee, Jooyoung Lee, Ju‐Hwa Kim, Hakhyun Kim, Minjee Kim, Ho‐Keun Kwon, Ho Lee, Hyun Seok Kim   +11 more
wiley   +1 more source

Rare Cryptosporidium hominis Subtype Associated with Aquatic Center Use

Emerging Infectious Diseases, 2008
Corinne S. L. Ong, Simon Chow, Reka Gustafson, Candace Plohman, Robert Parker, Judith L. Isaac-Renton, Murray W. Fyfe   +6 more
doaj   +1 more source

Valium without dependence? Individual GABAA receptor subtype contribution toward benzodiazepine addiction, tolerance, and therapeutic effects

, 2018
Tianze Cheng,1 Dominique Marie Wallace,2 Benjamin Ponteri,1 Mahir Tuli3 1Pitzer College, Claremont, CA, USA; 2Portland State University, Portland, OR, USA; 3University of British Columbia, Vancouver, BC, Canada Abstract: Benzodiazepines are one of the ...
Ponteri B, Cheng T, Tuli M, Wallace DM
core  

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source

Analysis of ABO serological phenotype and molecular biology results of 256 blood donors with ambiguous blood group

Zhongguo shuxue zazhi
Objective To correctly identify the blood group of ABO and study its molecular biological characteristics. Methods Blood samples from blood donors with discrepancies in forward and reverse typing using the microplate method were subjected to both saline ...
Lanlan CHEN, Yanhua ZHANG, Jin CHE, Feng LI, Jingmin MA, Jiahong ZHANG   +5 more
doaj   +1 more source

Neutralization Susceptibility of B Subtype Variant B′′ Primary HIV‐1 Isolates

, 1998
The HEC/FIOCRUZ Aids Clinical Research Groupp: V. G. V. SANTOS, V. C. Rolla, S. Cavalcante, M. C. G. Galhardo and M. R. C. Guimarães.Susceptibility to autologous and heterologous neutralization of primary human immunodeficiency virus (HIV)-1 isolates ...
Bongertz, Vera, Castro Filho, Bernardo Galvão, João Filho, Esaú Custódio, Morgado, Mariza Gonçalves, Grinsztejn, Beatriz, Costa, Catia Ines, Guimarães, Monick Lindenmeyer, Galvão‐Castro, Grinsztejn, Bongertz, João Filho, Guimarães, Costa, Morgado, The Hec/fiocruz Aids Clinical Research Group   +14 more
core   +1 more source

p190A/ARHGAP35 and p190B/ARHGAP5 proteins in endometrial cancer: a novel cancer‐relevant paralog interplay

Molecular Oncology, EarlyView.
This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault, Capucine Heraud, Mélissa Correia de Oliveira, Véronique Neaud, Valérie Valesco, Valérie Prouzet‐Mauleon, Béatrice Turcq, Jean‐William Dupuy, Anne‐Aurélie Raymond, Sabrina Croce, Frédéric Saltel, Valérie Lagrée, Violaine Moreau   +12 more
wiley   +1 more source

Comparison of ultrasound findings of papillary thyroid carcinoma subtypes based on the 2022 WHO classification of thyroid neoplasms

Frontiers in Endocrinology
PurposeThe present study aimed to analyze and compare sonographic features of papillary thyroid carcinoma (PTC) subtypes to determine whether ultrasound (US) may aid in differentiating particular subtypes.MethodsThis retrospective study enrolled 133 ...
İlhan Hekimsoy, Yeşim Ertan, Gürdeniz Serin, Ahmet Kasım Karabulut, Süha Süreyya Özbek   +4 more
doaj   +1 more source