Results 111 to 120 of about 560,921 (309)

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

First detection of tick‐borne encephalitis virus (TBEV) in raw milk samples in North‐Western Iran

Veterinary Medicine and Science
Tick‐borne encephalitis virus (TBEV) is a significant cause of flaviviral infections affecting the human central nervous system, primarily transmitted through tick bites and the consumption of unpasteurized milk. This study aimed to assess the prevalence
Angineh Parsadanians, Hessam Mirshahabi, Masoud Yavarmanesh   +2 more
doaj   +1 more source

Specialization in the iStar2.0 Language

IEEE Access, 2019
iStar2.0 has been proposed as a standard language for building goaland agent-oriented models. It is an evolution of the former i* language, with the purpose of homogenising existing syntactical and semantic variations of basic i* constructs that ...
Lidia Lopez, Xavier Franch, Jordi Marco
doaj   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Next-generation lung cancer pathology: Development and validation of diagnostic and prognostic algorithms

Cell Reports Medicine
Summary: Non-small cell lung cancer (NSCLC) is one of the most common malignant tumors. In this study, we develop a clinically useful computational pathology platform for NSCLC that can be a foundation for multiple downstream applications and provide ...
Carina Kludt, Yuan Wang, Waleed Ahmad, Andrey Bychkov, Junya Fukuoka, Nadine Gaisa, Mark Kühnel, Danny Jonigk, Alexey Pryalukhin, Fabian Mairinger, Franziska Klein, Anne Maria Schultheis, Alexander Seper, Wolfgang Hulla, Johannes Brägelmann, Sebastian Michels, Sebastian Klein, Alexander Quaas, Reinhard Büttner, Yuri Tolkach   +19 more
doaj   +1 more source

Epidemiology of Mycoplasma pneumoniae Infections in Japan and Therapeutic Strategies for Macrolide-resistant M. pneumoniae

Frontiers in Microbiology, 2016
Pneumonia caused by Mycoplasma pneumoniae (M. pneumoniae pneumonia) is a major cause of community-acquired pneumonia worldwide. The surveillance of M.
Tsutomu eYamazaki, Tsuyoshi eKenri
doaj   +1 more source

Insomnia heterogeneity: Characteristics to consider for data-driven multivariate subtyping.

Sleep Medicine Reviews, 2017
Meta-analyses and systematic reviews have reported surprisingly few consistent insomnia-characteristics with respect to cognitions, mood, traits, history of life events and family history.
J. Benjamins, F. Migliorati, K. Dekker, R. Wassing, S. Moens, T. Blanken, B. T. Te Lindert, Jeffrey Sjauw Mook, E. V. van Someren   +8 more
semanticscholar   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Abstract Combining Structural Subtyping and External Dispatch

, 2008
Nominal subtyping (or user-defined subtyping) and structural subtyping each have their own strengths and weaknesses. Nominal subtyping allows programmers to explicitly express design intent, and, when types are associated with run time tags, enables ...

core   +1 more source

Coercive Subtyping in Lambda-Free Logical Frameworks [PDF]

, 2009
We show how coercive subtyping may be added to a lambda-free logical framework, by constructing the logical framework ...
Adams, Robin, Robin Adams, Adams, Robin,
core   +1 more source