Results 91 to 100 of about 560,921 (309)
A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma
FEBS Letters, EarlyView.Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos +9 more
wiley +1 more source
AnimalsStaphylococcus aureus frequently causes intramammary infections in dairy cows (bovine mastitis), which impair animal welfare, milk yield, and food safety. This study determined the prevalence and genetic diversity of S.
Nasrin Ramezanigardaloud +6 more
doaj +1 more source
A novel approach for data integration and disease subtyping
Genome Research, 2017 Advances in high-throughput technologies allow for measurements of many types of omics data, yet the meaningful integration of several different data types remains a significant challenge.
Tin Nguyen +3 more
semanticscholar +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
On the Preciseness of Subtyping in Session Types [PDF]
, 2014 Subtyping in concurrency has been extensively studied since early 1990s as one of the most interesting issues in type theory. The correctness of subtyping relations has been usually provided as the soundness for type safety.
Dezani, Mariangiola +6 more
core +1 more source
, 1999 . Constructor subtyping is a form of subtyping in which an inductive type oe is viewed as a subtype of another inductive type ø if ø has more constructors than oe.
Maria Jo~ao Frade +2 more
core +2 more sources
Molecular Oncology, EarlyView.In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge +17 more
wiley +1 more source
IEEE Access, 2019 The task of virus classification into subtypes is an important concern in many categorization studies, e.g., in virology or epidemiology. Therefore, the problem of virus subtyping has been a subject of considerable interest in the last decade.
Anna Fabijanska, Szymon Grabowski
doaj +1 more source
Assessment and Comparison of Molecular Subtyping and Characterization Methods for Salmonella
Frontiers in Microbiology, 2019 The food industry is facing a major transition regarding methods for confirmation, characterization, and subtyping of Salmonella. Whole-genome sequencing (WGS) is rapidly becoming both the method of choice and the gold standard for Salmonella subtyping ...
Silin Tang +7 more
semanticscholar +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source