Results 71 to 80 of about 560,921 (309)

Constructor Subtyping (extended Version) [PDF]

open access: yes, 1999
Constructor subtyping is a form of subtyping in which an inductive type sigma is viewed as a subtype of another inductive type tau if tau has more constructors than sigma.
Maria Jo~ao Frade   +2 more
core   +1 more source

Pure type systems with subtyping

open access: yes, 1999
We extend the framework of Pure Type Systems with subtyping, as found in F = ¿ . This leads to a concise description of many existing systems with subtyping, and also to some new interesting systems.
Zwanenburg, J.
core   +1 more source

On Behavioural Subtyping in LOTOS [PDF]

open access: yes, 1997
We consider how the OO notion of subtyping relates to LOTOS testing theory. In particular, we investigate which of the standard LOTOS preorders is a suitable instantiation of behavioural subtyping and argue that each of the main preorders, trace preorder,
Briscoe-Smith, C.   +7 more
core   +1 more source

Organoids in pediatric cancer research

open access: yesFEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Development of a Subtyping Tool for Zoonotic Pathogen Cryptosporidium canis

open access: yesJournal of Clinical Microbiology, 2020
Cryptosporidium canis is an important cause of cryptosporidiosis in canines and humans. Studies of the transmission characteristics of C. canis are currently hampered by the lack of suitable subtyping tools. ABSTRACT Cryptosporidium canis is an important
Wen Jiang   +5 more
semanticscholar   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

open access: yesFEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Genetic Diversity of Hepatitis E Virus Type 3 in Switzerland—From Stable to Table

open access: yesAnimals, 2021
Hepatitis E caused by hepatitis E viruses of the genotype 3 (HEV-3) is a major health concern in industrialized countries and due to its zoonotic character requires a “One Health” approach to unravel routes and sources of transmission.
Isabelle Vonlanthen-Specker   +5 more
doaj   +1 more source

Proteomic profiling of extracellular vesicles allows for human breast cancer subtyping

open access: yesCommunications Biology, 2019
Extracellular vesicles (EVs) are a potential source of disease-associated biomarkers for diagnosis. In breast cancer, comprehensive analyses of EVs could yield robust and reliable subtype-specific biomarkers that are still critically needed to improve ...
S. Rontogianni   +7 more
semanticscholar   +1 more source

Parametric Subtyping for Structural Parametric Polymorphism

open access: yes, 2023
We study the interaction of structural subtyping with parametric polymorphism and recursively defined type constructors. Although structural subtyping is undecidable in this setting, we describe a notion of parametricity for type constructors and then ...
DeYoung, Henry   +3 more
core  

Structure‐forward targeting of claudins with synthetic binders

open access: yesFEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

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