Advances in protein subunit vaccines against tuberculosis [PDF]
Frontiers in Immunology, 2023 Tuberculosis (TB), also known as the “White Plague”, is caused by Mycobacterium tuberculosis (Mtb). Before the COVID-19 epidemic, TB had the highest mortality rate of any single infectious disease.
Xiao-Yong Fan, Jin-Chuan Xu
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Subunit vaccines for Acinetobacter baumannii [PDF]
Frontiers in Immunology, 2023 Acinetobacter baumannii is a gram-negative bacterium and a crucial opportunistic pathogen in hospitals. A. baumannii infection has become a challenging problem in clinical practice due to the increasing number of multidrug-resistant strains and their ...
Ning Yang +6 more
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Advances in protein subunit vaccines against H1N1/09 influenza [PDF]
Frontiers in ImmunologyThe A/H1N1pdm09 influenza virus, which caused the 2009 pandemic, has since become a recurring strain in seasonal influenza outbreaks. Given the ongoing threat of influenza, protein subunit vaccines have garnered significant attention for their safety and
Yu Zhang +9 more
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Carbohydrate Immune Adjuvants in Subunit Vaccines [PDF]
Pharmaceutics, 2020 Modern subunit vaccines are composed of antigens and a delivery system and/or adjuvant (immune stimulator) that triggers the desired immune responses.
Mariusz Skwarczyński +2 more
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Subunit Vaccines Against Emerging Pathogenic Human Coronaviruses
Frontiers in Microbiology, 2020 Seven coronaviruses (CoVs) have been isolated from humans so far. Among them, three emerging pathogenic CoVs, including severe acute respiratory syndrome coronavirus (SARS-CoV), Middle East respiratory syndrome coronavirus (MERS-CoV), and a newly ...
Lanying Du, Jiang Shibo, Jian Shang
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Adjuvants and Antigen-Delivery Systems for Subunit Vaccines against Tuberculosis
Vaccines, 2021 The only licensed vaccine against tuberculosis is BCG. However, BCG has failed to provide consistent protection against tuberculosis, especially pulmonary disease in adults.
Abu Salim Mustafa
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Evaluation of immunogenicity of gene-deleted and subunit vaccines constructed against the emerging pseudorabies virus variants [PDF]
Virology Journal, 2023 Background Pseudorabies (PR) (also called Aujeszky’s disease, AD) is a serious infectious disease affecting pigs and other animals worldwide. The emergence of variant strains of pseudorabies virus (PRV) since 2011 has led to PR outbreaks in China and a ...
Hong-liang Zhang +6 more
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Enhancing vaccine half-life as a novel strategy for improving immune response durability of subunit vaccines. [PDF]
PLoS PathogensVaccines are widely regarded as one of the most effective strategies for combating infectious diseases. However, significant challenges remain, such as insufficient antibody levels, limited protection against rapidly evolving variants, and poor immune ...
Zhaoling Shen +8 more
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A platform technology for generating subunit vaccines against diverse viral pathogens [PDF]
Frontiers in Immunology, 2022 The COVID-19 pandemic response has shown how vaccine platform technologies can be used to rapidly and effectively counteract a novel emerging infectious disease.
Andrew Young +28 more
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Advanced subunit vaccine delivery technologies: From vaccine cascade obstacles to design strategies
Acta Pharmaceutica Sinica B, 2023 Designing and manufacturing safe and effective vaccines is a crucial challenge for human health worldwide. Research on adjuvant-based subunit vaccines is increasingly being explored to meet clinical needs.
Yingying Hou +5 more
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