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Advances in protein subunit vaccines against tuberculosis [PDF]
Frontiers in Immunology, 2023 Tuberculosis (TB), also known as the “White Plague”, is caused by Mycobacterium tuberculosis (Mtb). Before the COVID-19 epidemic, TB had the highest mortality rate of any single infectious disease.
Ying Zhang +5 more
doaj +6 more sources
Carbohydrate Immune Adjuvants in Subunit Vaccines [PDF]
Pharmaceutics, 2020 Modern subunit vaccines are composed of antigens and a delivery system and/or adjuvant (immune stimulator) that triggers the desired immune responses.
Sahra Bashiri +3 more
doaj +9 more sources
Subunit vaccines for Acinetobacter baumannii [PDF]
Frontiers in Immunology, 2023 Acinetobacter baumannii is a gram-negative bacterium and a crucial opportunistic pathogen in hospitals. A. baumannii infection has become a challenging problem in clinical practice due to the increasing number of multidrug-resistant strains and their ...
Ning Yang +6 more
doaj +4 more sources
Advances in protein subunit vaccines against H1N1/09 influenza [PDF]
Frontiers in ImmunologyThe A/H1N1pdm09 influenza virus, which caused the 2009 pandemic, has since become a recurring strain in seasonal influenza outbreaks. Given the ongoing threat of influenza, protein subunit vaccines have garnered significant attention for their safety and
Yu Zhang +9 more
doaj +4 more sources
Delivery of STING agonists for adjuvanting subunit vaccines
Advanced Drug Delivery Reviews, 2021 Adjuvant is an essential component in subunit vaccines. Many agonists of pathogen recognition receptors have been developed as potent adjuvants to optimize the immunogenicity and efficacy of vaccines. Recently discovered cyclic GMP-AMP synthase-stimulator of interferon genes (cGAS-STING) pathway has attracted much attention as it is a key mediator for ...
Simon Van Herck, Bing Feng, Li Tang
exaly +4 more sources
Adjuvants and Antigen-Delivery Systems for Subunit Vaccines against Tuberculosis
Vaccines, 2021 The only licensed vaccine against tuberculosis is BCG. However, BCG has failed to provide consistent protection against tuberculosis, especially pulmonary disease in adults.
Abu Salim Mustafa
doaj +2 more sources
Advances in Oral Subunit Vaccine Design [PDF]
Vaccines, 2020 Many pathogens invade the host at the intestinal surface. To protect against these enteropathogens, the induction of intestinal secretory IgA (SIgA) responses is paramount. While systemic vaccination provides strong systemic immune responses, oral vaccination is the most efficient way to trigger protective SIgA responses.
Hans Van der Weken +2 more
openaire +6 more sources
Vaccines, 2021 A recently reported parallel preclinical study between a severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) mRNA vaccine and an inactivated SARS-CoV-2 vaccine adjuvanted with alum showed pulmonary immunopathology typical of eosinophil ...
Han Cao +6 more
doaj +2 more sources
Evaluation of immunogenicity of gene-deleted and subunit vaccines constructed against the emerging pseudorabies virus variants [PDF]
Virology Journal, 2023 Background Pseudorabies (PR) (also called Aujeszky’s disease, AD) is a serious infectious disease affecting pigs and other animals worldwide. The emergence of variant strains of pseudorabies virus (PRV) since 2011 has led to PR outbreaks in China and a ...
Hong-liang Zhang +6 more
doaj +2 more sources
Enhancing vaccine half-life as a novel strategy for improving immune response durability of subunit vaccines. [PDF]
PLoS PathogensVaccines are widely regarded as one of the most effective strategies for combating infectious diseases. However, significant challenges remain, such as insufficient antibody levels, limited protection against rapidly evolving variants, and poor immune ...
Zhaoling Shen +8 more
doaj +2 more sources