Results 11 to 20 of about 471,587 (292)

Advances in Oral Subunit Vaccine Design [PDF]

Vaccines, 2020
Many pathogens invade the host at the intestinal surface. To protect against these enteropathogens, the induction of intestinal secretory IgA (SIgA) responses is paramount. While systemic vaccination provides strong systemic immune responses, oral vaccination is the most efficient way to trigger protective SIgA responses.
Hans Van der Weken, Eric Cox, Bert Devriendt   +2 more
openaire   +6 more sources

An Established Th2-Oriented Response to an Alum-Adjuvanted SARS-CoV-2 Subunit Vaccine Is Not Reversible by Sequential Immunization with Nucleic Acid-Adjuvanted Th1-Oriented Subunit Vaccines

Vaccines, 2021
A recently reported parallel preclinical study between a severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) mRNA vaccine and an inactivated SARS-CoV-2 vaccine adjuvanted with alum showed pulmonary immunopathology typical of eosinophil ...
Han Cao, Shengran Yang, Yunfei Wang, Ning Luan, Xingxiao Yin, Kangyang Lin, Cunbao Liu   +6 more
doaj   +2 more sources

Research Progress on Varicella-Zoster Virus Vaccines

Vaccines
Varicella-zoster virus (VZV) poses significant public health challenges as the etiological agent of varicella (chickenpox) and herpes zoster (HZ), given its high transmissibility and potential for severe complications.
Hongjing Liu, Lingyan Cui, Sibo Zhang, Hong Wang, Wenhui Xue, Hai Li, Yuyun Zhang, Lin Chen, Ying Gu, Tingting Li, Ningshao Xia, Shaowei Li   +11 more
doaj   +2 more sources

Vaccine Platform-Dependent Differential Impact on Microbiome Diversity: Potential Advantages of Protein Subunit Vaccines. [PDF]

Vaccines (Basel)
Background: The COVID-19 pandemic accelerated the development of diverse vaccine platforms, including mRNA, adenoviral vector, and protein subunit vaccines. Given the growing evidence that the gut microbiome modulates vaccine-induced immunity, this study
Seong H, Yoon JG, Nham E, Choi YJ, Noh JY, Cheong HJ, Kim WJ, Lim S, Song JY.   +8 more
europepmc   +2 more sources

Adjuvant Selection for Influenza and RSV Prefusion Subunit Vaccines [PDF]

, 2021
Subunit vaccines exhibit favorable safety and immunogenicity profiles and can be designed to mimic native antigen structures. However, pairing with an appropriate adjuvant is imperative in order to elicit effective humoral and cellular immune responses ...
Naphak Modhiran, Chappell, K.J., Danushka K. Wijesundara, Christopher L. D. McMillan, Young, P.R., Watterson, D., Paul R. Young, Li, Z., Isaacs, A., Modhiran, N., Zheyi Li, Daniel Watterson, Stacey T. M. Cheung, Charani Ranasinghe, Ranasinghe, C., Ariel Isaacs, McMillan, C.L.D., Keith J. Chappell, Cheung, S.T.M., Wijesundara, D.K.   +19 more
core   +1 more source

Adjuvants : an essential component of neisseria vaccines [PDF]

, 2009
Adjuvants may be classified into delivery systems and immune potentiator or modulator molecules based on their mechanism of action. Neisseria vaccines containing traditional adjuvants such as aluminium salts have existed for long time, but meningitis ...
Acevedo, R., del Campo, J., Zayas, C., Cuello, M., Romeu, B., Ferro, Valerie A., Gonzales, E., Cabrera, O., Balbao, J.   +8 more
core   +4 more sources

Microneedle array delivered recombinant coronavirus vaccines: Immunogenicity and rapid translational development

EBioMedicine, 2020
Background: Coronaviruses pose a serious threat to global health as evidenced by Severe Acute Respiratory Syndrome (SARS), Middle East Respiratory Syndrome (MERS), and COVID-19.
Eun Kim, Geza Erdos, Shaohua Huang, Thomas W. Kenniston, Stephen C. Balmert, Cara Donahue Carey, V. Stalin Raj, Michael W. Epperly, William B. Klimstra, Bart L. Haagmans, Emrullah Korkmaz, Louis D. Falo, Jr., Andrea Gambotto   +12 more
doaj   +1 more source

A Sneak Peek into COVID-19 Vaccines-Present Status [PDF]

Journal of Clinical and Diagnostic Research, 2021
The Coronavirus Disease 2019 (COVID-19) pandemic has taken a toll on all of us for one year with more than 1.94 million deaths. Despite many educational interventions and precautionary measures, there is increasing number of cases with rising mortality.
SWATHI GURAJALA
doaj   +1 more source

Research Progress on the Development of Porcine Reproductive and Respiratory Syndrome Vaccines

Veterinary Sciences, 2023
Porcine reproductive and respiratory syndrome (PRRS) is a highly contagious disease in the pig industry, but its pathogenesis is not yet fully understood.
Hang Zhang, Qin Luo, Yingxin He, Yajie Zheng, Huiyang Sha, Gan Li, Weili Kong, Jiedan Liao, Mengmeng Zhao   +8 more
doaj   +1 more source

Assembly, Biochemical Characterization, Immunogenicity, Adjuvanticity, and Efficacy of Shigella Artificial Invaplex

mSphere, 2018
The native Invaplex (InvaplexNAT) vaccine and adjuvant is an ion exchange-purified product derived from the water extract of virulent Shigella species.
K. Ross Turbyfill, Kristen A. Clarkson, Anthony R. Vortherms, Edwin V. Oaks, Robert W. Kaminski   +4 more
doaj   +1 more source