Results 231 to 240 of about 79,320 (275)

Modern Subunit Vaccines: Development, Components, and Research Opportunities

ChemMedChem, 2013
Traditional vaccines, based on the administration of killed or attenuated microorganisms, have proven to be among the most effective methods for disease prevention.
Peter M Moyle, István Tóth
exaly   +2 more sources

Protein subunit vaccines: Promising frontiers against COVID-19

Journal of Controlled Release
The emergence of COVID-19 has posed an unprecedented global health crisis, challenging the healthcare systems worldwide. Amidst the rapid development of several vaccine formulations, protein subunit vaccines have emerged as a promising approach.
Vivek P Chavda, Subhash C Chauhan, Vandana Patravale   +2 more
exaly   +1 more source

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Rotavirus subunit vaccines

1996
We evaluated rotavirus subunit vaccines for use in humans and animals. Insect cells were co-infected with combinations of individual baculovirus recombinants expressing human, bovine or simian rotavirus VP2, VP4, VP6 or VP7 to produce virus-like particles (VLPs).
Conner, M.E., Crawford, S.E., Barone, C., O'Neal, C., Zhou, Y.J., Fernandez, F., Parwani, A., Saif, L.J., Cohen, J., Estes, M.K.   +9 more
openaire   +3 more sources

Recombinant subunit vaccines

Current Opinion in Biotechnology, 1991
Research that may lead to the development of recombinant DNA-based vaccines has been conducted on a broad front. This has resulted in an increased understanding of immunological responsiveness to vaccines, the rational engineering of immunogens, and new means of delivering vaccines.
openaire   +2 more sources

Pulmonary Administration of Subunit Vaccines

2014
Pulmonary administration of vaccines might overcome some of the disadvantages related to administration by needle. The lungs are equipped with various immune cells through which a systemic as well as a mucosal immune response can be induced. Different types of devices and formulations can be used to administer vaccines to the lungs, each with their own
Tonnis, Wouter F., Huckriede, Anke L.W., Hinrichs, Wouter L.J., Frijlink, Henderik W.   +3 more
openaire   +2 more sources

The herpes zoster subunit vaccine

Expert Opinion on Biological Therapy, 2016
Herpes zoster (HZ) causes severe pain and rash in older people and may be complicated by prolonged pain (postherpetic neuralgia; PHN).HZ results from reactivation of latent varicella-zoster virus (VZV) infection, often associated with age related or other causes of decreased T cell immunity.
openaire   +2 more sources

EFFECTIVE PROTECTION AGAINST INFLUENZA AFTER VACCINATION WITH SUBUNIT VACCINE

Medical Journal of Australia, 1978
Immunization with an influenza subunit vaccine given in one dose about 1 month to 2 months before onset of an epidemic of influenza afforded from 80% to 90% protection in a double-blind clinical trial which was supported by isolation of virus and serological studies. In the vaccinated group, 20% failed to develop antibodies to the vaccine.
M L, Hammond, A A, Ferris, S, Faine, T, McAvan   +3 more
openaire   +2 more sources

Feline calicivirus subunit vaccine - a prototype

Antiviral Research, 1985
A vaccine was prepared from a subunit component, antigenically similar to the whole feline calicivirus (FCV) particles. Despite the limited number of animals available for this study we were able to demonstrate that the vaccine protected cats when challenged with a virulent strain of the virus while the non-vaccinates kept as controls developed ...
O O, Komolafe, O, Jarrett
openaire   +2 more sources

Infectious Bursal Disease Subunit Vaccination

Avian Diseases, 2008
Infectious bursal disease virus (IBDV) is the causative agent of infectious bursal disease, a nosologic entity with global economic importance in poultry. The viral protein 2 (VP2) is recognized as the virus' major antigenic protein. The goal of this study was to generate yeast (Pichia pastoris)-based protein expression from the VP2 gene of the Edgar ...
Pedro, Villegas, M, Hamoud, L B, Purvis, F, Perozo   +3 more
openaire   +2 more sources

KILLED SUBUNIT INFLUENZA VACCINE IN CHILDREN

Pediatrics, 1973
Thirty-three children ranging in age from 5 to 9 years were immunized with varying doses of bivalent A2 (Hong Kong variant) B subunit influenza vaccine. The immunization was given intramuscularly. There were no local or systemic reactions. Thirty-one of 33 children (94%) demonstrated four-fold or greater rises in antibody titer to type A antigen ...
C F, Phillips, C A, Phillips, W E, Hodgkin, B R, Forsyth, B A, Rubin, M E, Geraghty   +5 more
openaire   +2 more sources