Results 51 to 60 of about 79,320 (275)

A New Rabbit-Skin Model to Evaluate Protective Efficacy of Tuberculosis Vaccines

Frontiers in Microbiology, 2017
Background: BCG protection is suboptimal and there is significant interest to develop new tuberculosis (TB) vaccines. However, there are significant limitations of the current vaccine evaluation systems in the mouse model.
Huiyu Chen, Huiyu Chen, Xun Liu, Xun Liu, Xingming Ma, Xingming Ma, Qian Wang, Qian Wang, Guang Yang, Hongxia Niu, Hongxia Niu, Shuaixiang Li, Bingzheng He, Shanshan He, Shanshan He, Arthur M. Dannenberg, Bingdong Zhu, Bingdong Zhu, Ying Zhang   +18 more
doaj   +1 more source

Polymers for subunit vaccine delivery

, 2019
Mimicking the size and structural features of a pathogen is critical in developing immunity through subunit vaccines; it has been shown that this can be successfully achieved by nano-sized delivery systems and carriers.
Skwarczynski, Mariusz, Nevagi, Reshma J, Toth, Istvan   +2 more
core   +1 more source

Fc-Mediated E2-Dimer Subunit Vaccines of Atypical Porcine Pestivirus Induce Efficient Humoral and Cellular Immune Responses in Piglets

, 2021
Congenital tremor (CT) type A-II in piglets is caused by an emerging atypical porcine pestivirus (APPV), which is prevalent in swine herds and a serious threat to the pig production industry.
Shudan Liu, Huanchun Chen, Xujiao Ren, Ping Qian, Xiangmin Li   +4 more
core   +1 more source

ProSiteHunter: A Unified Framework for Sequence‐Based Prediction of Protein‐Nucleic Acid and Protein‐Protein Binding Sites

Advanced Science, EarlyView.
This study proposed a unified sequence‐based framework for protein binding site prediction, which adopted a tri‐track semantic multi‐source feature fusion strategy to effectively capture diverse macromolecular interaction sites and further improved the accuracy of antibody‐antigen interaction prediction.
Dongliang Hou, Qihang Zhen, Zexin Lv, Xinyue Cui, Suhui Wang, Minghua Hou, Zhan Zhou, Xiaogen Zhou, Guijun Zhang   +8 more
wiley   +1 more source

Novel Administration Routes, Delivery Vectors, and Application of Vaccines Based on Biotechnologies: A Review

Vaccines
Traditional vaccines can be classified into inactivated vaccines, live attenuated vaccines, and subunit vaccines given orally or via intramuscular (IM) injection or subcutaneous (SC) injection for the prevention of infectious diseases.
Chung-I Rai, Tsu-Hsiang Kuo, Yuan-Chuan Chen   +2 more
doaj   +1 more source

Porcine Circovirus Type 2 Vaccines: Commercial Application and Research Advances

, 2022
Porcine circovirus type 2 (PCV2) infection can lead to porcine circovirus-associated disease (PCVAD), causing great economic losses to the global swine industry.
Guo, Jinshuo, Jue Liu, Zhou, Jianwei, Liu, Jue, Hou, Lei, Dedong Wang, Yongqiu Cui, Xufei Feng, Lei Hou, Jinshuo Guo, Jianwei Zhou, Cui, Yongqiu, Wang, Dedong, Feng, Xufei   +13 more
core   +1 more source

Conformational Snapshots of CydDC in a Native Lipid Bilayer Coupling Heme Transport to Antibiotic Resistance

Advanced Science, EarlyView.
Phylogenetic and biochemical analyses of the heme transporter CydDC reveal its functional conservation throughout bacterial evolution and demonstrate its unique asymmetric allosteric mechanism. Furthermore, impairment of CydDC function directly affects bacterial antibiotic resistance and likely compromises antibiotic efficacy through drug efflux.
Lili Yang, Changbin Zhang, Mengyuan Lyu, Yongbo Luo, Jierou Zhang, Yujiao Chen, Lintao Luo, Wen Qiao, Xiangyangpeng Li, Yu Zhou, Zhongling Wei, Yuling Xiao, Qian Niu, Juan Zhou, Guanglin He, Binwu Ying, Zhaoming Su, Hao Chen, Xiaodi Tang, Haohao Dong   +19 more
wiley   +1 more source

Current strategies, advances, and challenges in multi-epitope subunit vaccine development for African swine fever virus

Veterinary Integrative Sciences
African Swine Fever (ASF), a highly contagious and lethal viral disease affecting swine populations, presents a critical global threat with no approved vaccine.
Ella Mae Joy S. Sira, Edward C. Banico, Lauren Emily Fajardo, Nyzar Mabeth O. Odchimar, Alea Maurice Simbulan, Fredmoore L. Orosco   +5 more
doaj   +1 more source

Protection of Mice from Lethal Vaccinia Virus Infection by Vaccinia Virus Protein Subunits with a CpG Adjuvant

Viruses, 2017
Smallpox vaccination carries a high risk of adverse events in recipients with a variety of contra-indications for live vaccines. Although alternative non-replicating vaccines have been described in the form of replication-deficient vaccine viruses, DNA ...
Sarah Reeman, Amanda J. Gates, David J. Pulford, Art Krieg, David O. Ulaeto   +4 more
doaj   +1 more source

Hemoglobin's α‐Helix‐to‐β‐Sheet Transition Enables Targeted mRNA Delivery to the Lung

Advanced Science, EarlyView.
Acidic heating converts hemoglobin into β‐sheet‐rich fibrils with positively charged surfaces. These hemoglobin fibrils electrostatically complex IL‐11 scFv mRNA, selectively bind circulating platelets, and hitchhike to the lung, where they are enriched in fibroblasts.
Xihua Liu, Saiya Li, Guodong Wu, Shuangjian Li, Long Shuang Huang, Xiaoyang Li, Yiguo Zhao, Wei Lu, Cuixia Sun, Qin Cao, Yapeng Fang, Yiping Cao   +11 more
wiley   +1 more source