Results 51 to 60 of about 471,587 (292)

Novel Administration Routes, Delivery Vectors, and Application of Vaccines Based on Biotechnologies: A Review

Vaccines
Traditional vaccines can be classified into inactivated vaccines, live attenuated vaccines, and subunit vaccines given orally or via intramuscular (IM) injection or subcutaneous (SC) injection for the prevention of infectious diseases.
Chung-I Rai, Tsu-Hsiang Kuo, Yuan-Chuan Chen   +2 more
doaj   +1 more source

Protection of Mice from Lethal Vaccinia Virus Infection by Vaccinia Virus Protein Subunits with a CpG Adjuvant

Viruses, 2017
Smallpox vaccination carries a high risk of adverse events in recipients with a variety of contra-indications for live vaccines. Although alternative non-replicating vaccines have been described in the form of replication-deficient vaccine viruses, DNA ...
Sarah Reeman, Amanda J. Gates, David J. Pulford, Art Krieg, David O. Ulaeto   +4 more
doaj   +1 more source

Recent progress in the development of plant derived vaccines

, 2022
S.1173-1183Recombinant subunit vaccines have been with us for the last 30 years and they provide us with the unique opportunity to choose from the many available production systems that can be used for recombinant protein expression.
Rabindran, S., Yusibov, V.
core   +1 more source

Advanced Materials for Biologics Delivery to Brain Tumors

Advanced Materials, EarlyView.
Material innovation is central to unlocking the therapeutic potential of biologics against many central nervous system diseases, including brain cancer. By engineering carriers with controlled transport, targeting, and release properties, advanced materials can overcome the blood–brain barrier and tumor microenvironment, improving the delivery of ...
Yuran Feng, Yuxue Cao, Maria Kavallaris, Taskeen Janjua, Amirali Popat   +4 more
wiley   +1 more source

Engineering Microbial Particles for Next‐Generation Biomedical Platforms

Advanced Science, EarlyView.
Microbe‐derived particles (MDPs), which include extracellular vesicles, outer membrane vesicles, inclusion bodies, polysaccharide particles, and virus‐like particles, represent a rapidly expanding category of bioinspired nanomaterials. With their natural origin, intrinsic biocompatibility, and highly programmable functionality, MDPs serve as a ...
Yuting Li, Yunjie Lu, Ziyan Huang, Jianjiang Chen, Yanbin Liu, Lei Qin, Chao Wang, Yumin Wu   +7 more
wiley   +1 more source

Current strategies, advances, and challenges in multi-epitope subunit vaccine development for African swine fever virus

Veterinary Integrative Sciences
African Swine Fever (ASF), a highly contagious and lethal viral disease affecting swine populations, presents a critical global threat with no approved vaccine.
Ella Mae Joy S. Sira, Edward C. Banico, Lauren Emily Fajardo, Nyzar Mabeth O. Odchimar, Alea Maurice Simbulan, Fredmoore L. Orosco   +5 more
doaj   +1 more source

Overview of current advances in the development of subunit and recombinant vaccines against Newcastle disease virus [PDF]

Biotechnology in Animal Husbandry, 2017
Newcastle disease virus (NDV) is one of the most important viral pathogens of avian species and the causative agent of atypical fowl plague, a highly contagious and economically important disease characterized by high mortality rates and reduction of egg
Milić Nenad, Nišavić Jakov, Zorić Andrea, Krnjaić Dejan, Radojičić Marina, Stanojković Aleksandar   +5 more
doaj  

Targeting antigens to an invariant epitope of the MHC Class II DR molecule potentiates the immune response to subunit vaccines

, 2011
Recombinant subunit and peptidic vaccines in general present a reduced immunogenicity in vaccinated individuals with respect to the whole pathogen from which they derived.
Covadonga Alonso, Pérez-Filgueira, Mariano, Escribano, J. M., Félix Gil, Vivanco Martínez, Fernando, Fernando Vivanco, Vivanco, F., María G. Barderas, Pastor Vargas, Carlos, Alonso, Covadonga, Escribano, José M, Mariano Pérez-Filgueira, José M. Escribano, Gil Dones, Félix, Escribano, José, Vivanco, Fernando, Alonso Martí, Covadonga, Gonzalez Barderas, María, Pastor-Vargas, C., Carlos Pastor-Vargas, Barderas, María G., Gil, Félix, Barderas, María, Pérez-Filgueira, M.   +23 more
core   +1 more source

Recombinant subunit vaccines for soil-transmitted helminths [PDF]

, 2018
Soil-transmitted helminths (STHs) collectively infect one fourth of all human beings, and the majority of livestock in the developing world. These gastrointestinal nematodes are the most important parasites on earth with regard to their prevalence in ...
Aroian, Raffi V, Noon, Jason B.
core   +1 more source

Single‐Cell and Spatial Transcriptomics Unveil Key Regulators Governing Cell Differentiation for Schistosoma japonicum Sexual Development

Advanced Science, EarlyView.
Using single‐cell and spatial transcriptomics, we identified key regulators that govern cell differentiation involved in parasite development and egg laying in Schistosoma japonicum. This comprehensive study establishes a foundational resource for understanding schistosome biology, deciphers the regulatory programs underlying cell differentiation and ...
Zhigang Lu, Xiaoxu Wang, Shun Li, Xuxin Li, Pengfei Du, Yameng Zheng, Lu Liu, Yanyan Zhang, Omri Wurtzel, Guofeng Cheng   +9 more
wiley   +1 more source