Results 1 to 10 of about 21,681 (186)

Subventricular zone involvement is associated with worse outcome in glioma WHO grade 2 depending on molecular markers

Scientific Reports, 2021
Neural stem cells within the subventricular zone were identified as cells of origin driving growth of high-grade gliomas, and anatomical involvement of the subventricular zone has been associated with an inferior clinical outcome. Whether the association
Philipp Karschnia, Jonathan Weller, Jens Blobner, Veit M. Stoecklein, Mario M. Dorostkar, Kai Rejeski, Robert Forbrig, Maximilian Niyazi, Louisa von Baumgarten, Jorg Dietrich, Joerg-Christian Tonn, Niklas Thon   +11 more
doaj   +1 more source

Targeting the neural stem cells in subventricular zone for the treatment of glioblastoma: an update from preclinical evidence to clinical interventions

Stem Cell Research & Therapy, 2023
Background Glioblastoma is one of the most common and aggressive adult brain tumors. The conventional treatment strategy, surgery combined with chemoradiotherapy, did not change the fact that the recurrence rate was high and the survival rate was low ...
Sijia Li, Lihua Dong, Zhenyu Pan, Guozi Yang   +3 more
doaj   +1 more source

Periventricular zone involvement as a predictor of survival in glioblastoma patients: A single centre cohort-comparison investigation concerning a distinct clinical entity

Interdisciplinary Neurosurgery, 2021
Background: Glioblastoma (GBM) contacting the Subventricular Zone (SVZ) may display a more aggressive pattern of invasiveness with higher potential to recruit migratory progenitor cells.
Daniele Armocida, Alessandro Pesce, Mauro Palmieri, Giancarlo D'Andrea, Maurizio Salvati, Antonio Santoro, Alessandro Frati   +6 more
doaj   +1 more source

To Become or Not to Become Tumorigenic: Subventricular Zone Versus Hippocampal Neural Stem Cells

Frontiers in Oncology, 2020
Neural stem cells (NSCs) persist in the adult mammalian brain in two neurogenic regions: the subventricular zone lining the lateral ventricles and the dentate gyrus of the hippocampus.
Ángela Fontán-Lozano, Sara Morcuende, Mª América Davis-López de Carrizosa, Beatriz Benítez-Temiño, Rebeca Mejías, Esperanza R. Matarredona   +5 more
doaj   +1 more source

ADAM10 facilitates rapid neural stem cell cycling and proper positioning within the subventricular zone niche via JAMC/RAP1Gap signaling

Neural Regeneration Research, 2022
[INLINE:1] The mechanisms that regulate neural stem cell (NSC) lineage progression and maintain NSCs within different domains of the adult neural stem cell niche, the subventricular zone are not well defined.
Nadia McMillan, Gregory W Kirschen, Sanket Desai, Emma Xia, Stella E Tsirka, Adan Aguirre   +5 more
doaj   +1 more source

Wnt signaling enhances neurogenesis and improves neurological function after focal ischemic injury. [PDF]

PLoS ONE, 2012
Stroke potently stimulates cell proliferation in the subventricular zone of the lateral ventricles with subsequent neuroblast migration to the injured striatum and cortex. However, most of the cells do not survive and mature.
Adi Shruster, Tali Ben-Zur, Eldad Melamed, Daniel Offen   +3 more
doaj   +1 more source

TULP4, a novel E3 ligase gene, participates in neuronal migration as a candidate in schizophrenia

CNS Neuroscience &Therapeutics, EarlyView., 2023
Mutations identified from four SCZ pedigrees resulted in decreased TULP4 expression. Tulp4 knockdown caused delayed neuron migration in embryonic mice, and impaired cognition and prepulse inhibition in adult mice. These phenotypes may be related to TULP4 through its involvement in the formation of a novel E3 ubiquitin ligases.
Yan Bi, Decheng Ren, Fan Yuan, Zhou Zhang, Daizhan Zhou, Xin Yi, Lei Ji, Keyi Li, Fengping Yang, Xi Wu, Xingwang Li, Yifeng Xu, Yun Liu, Peng Wang, Changqun Cai, Chuanxin Liu, Qian Ma, Lin He, Yi Shi, Guang He   +19 more
wiley   +1 more source

Adult neural stem cell dysfunction in the subventricular zone of the lateral ventricle leads to diabetic olfactory defects

Neural Regeneration Research, 2017
Sensitive smell discrimination is based on structural plasticity of the olfactory bulb, which depends on migration and integration of newborn neurons from the subventricular zone.
Yu-hong Jing, Chu-chu Qi, Li Yuan, Xiang-wen Liu, Li-ping Gao, Jie Yin   +5 more
doaj   +1 more source

Protein expression differs between neural progenitor cells from the adult rat brain subventricular zone and olfactory bulb

BMC Neuroscience, 2008
Background Neural progenitor cells can be isolated from various regions of the adult mammalian brain, including the forebrain structures of the subventricular zone and the olfactory bulb.
Bürgers Heinrich F, Feldmann Robert E, Maurer Martin H, Kuschinsky Wolfgang   +3 more
doaj   +1 more source

Neural progenitor cells isolated from the subventricular zone present hemichannel activity and form functional gap junctions with glial cells

Frontiers in Cellular Neuroscience, 2015
The postnatal subventricular zone lining the walls of the lateral ventricles contains neural progenitor cells (NPCs) that generate new olfactory bulb interneurons.
Rocío eTalaverón, Paola eFernández, Rosalba eEscamilla, Angel M. Pastor, Esperanza R. Matarredona, Juan Carlos eSáez   +5 more
doaj   +1 more source