Results 41 to 50 of about 21,681 (186)

Rejuvenating subventricular zone neurogenesis in the aging brain

Current Opinion in Pharmacology, 2020
Neural stem cells exist in specialized regions of the brain and have the capacity to give rise to neurons and glia over the lifespan. The process of giving rise to new neurons, also known as neurogenesis, is thought to be important in cognition and certain types of brain repair.
Ronald R Cutler, Erzsebet Kokovay
openaire   +2 more sources

Single-Cell Analysis of Regional Differences in Adult V-SVZ Neural Stem Cell Lineages

Cell Reports, 2019
Summary: The ventricular-subventricular zone (V-SVZ) harbors adult neural stem cells. V-SVZ neural stem cells exhibit features of astrocytes, have a regional identity, and depending on their location in the lateral or septal wall of the lateral ventricle,
Dogukan Mizrak, Hanna Mendes Levitin, Ana C. Delgado, Valerie Crotet, Jinzhou Yuan, Zayna Chaker, Violeta Silva-Vargas, Peter A. Sims, Fiona Doetsch   +8 more
doaj   +1 more source

Translational Considerations for Injectable Biomaterials and Bioscaffolds to Repair and Regenerate Brain Tissue

Advanced Healthcare Materials, EarlyView.
The repair and regeneration of brain tissue faces both biological and technical challenges. Injectable bioscaffolds offer new opportunities to stimulate tissue regrowth in the brain by recruiting neural stem cells. Here, the translational issues are reviewed that need to be address to advance this promising new therapeutic approach from the bench to ...
Michel Modo, Alena Kisel
wiley   +1 more source

Intractable Headache Related to Intraventricular Glioblastoma: A Case Report and Literature Review

대한영상의학회지, 2019
Although various neoplasms may develop in the ventricular system, glioblastomas are rare. An 80-year-old woman visited our hospital with intractable headache related to a right ventricular large mass, which exhibited heterogeneous enhancement involving
Dong Yoon Han, Kyung Mi Lee, Hyug-Gi Kim, Eui Jong Kim   +3 more
doaj   +1 more source

Adult subventricular zone neural stem cells as a potential source of dopaminergic replacement neurons

Frontiers in Neuroscience, 2014
Clinical trials engrafting human fetal ventral mesencephalic tissue have demonstrated, in principle, that cell replacement therapy provides substantial long-lasting improvement of motor impairments generated by Parkinson’s Disease.
John eCave, John eCave, Meng eWang, Meng eWang, Harriet eBaker, Harriet eBaker   +5 more
doaj   +1 more source

Engineered Microfluidic Organoid Systems: New Paradigms for Menopause Mechanism Research and Personalized Medicine

Advanced Materials Technologies, EarlyView.
This review explores the integration of microfluidic technology with organoid systems as an innovative platform for studying menopausea complex multi‐organ condition. By enabling precise simulation of inter‐organ communication and hormone responses, microfluidic organoids offer a physiologically relevant model for investigating menopausal syndrome and ...
Qianyi Zhang, He Huang, Hongliang Dong, Qiang Ma, Hongyan Jin   +4 more
wiley   +1 more source

Activated regulatory T cell regulates neural stem cell proliferation in the subventricular zone of normal and ischemic mouse brain through interleukin 10

Frontiers in Cellular Neuroscience, 2015
Recent studies have demonstrated that the depletion of Regulatory T cells (Tregs) inhibits neural progenitor cell migration after brain ischemia. However, whether Tregs affect neural stem/progenitor cell proliferation is unclear.
Jixian eWang, Jixian eWang, Jixian eWang, Luokun eXie, Chenqi eYang, Changhong eRen, kaijing eZhou, Brian eWang, Zhijun eZhang, Yongting eWang, Kunlin eJin, Guo-Yuan eYang, Guo-Yuan eYang   +12 more
doaj   +1 more source

Long‐Term Effects of Xenotransplantation of Human Enteric Glia in an Immunocompetent Rat Model of Acute Brain Injury

Advanced Science, EarlyView.
Acute brain injuries are characterized by extensive tissue damage, resulting in debilitating deficits in patients. Despite considerable progress, cell‐based approaches have yet to identify an ideal candidate. This long‐term study explores the use of an untested cell source – human enteric glia – and a non‐invasive administration route – intranasal ...
Nina Colitti, Edwige Rice, Franck Desmoulin, Maylis Combeau, Mélissa Parny, Lorenne Robert, Etienne Buscail, Barbara Bournet, Nathalie Vergnolle, Isabelle Raymond‐Letron, Isabelle Loubinoux, Carla Cirillo   +11 more
wiley   +1 more source

Subventricular zones: new key targets for glioblastoma treatment [PDF]

Radiation Oncology, 2017
We aimed to identify subventricular zone (SVZ)-related prognostic factors of survival and patterns of recurrence among patients with glioblastoma.Forty-three patients with primary diagnosed glioblastoma treated in our Cancer Center between 2006 and 2010 were identified.
J. Khalifa, F. Tensaouti, A. Lusque, B. Plas, J.-A. Lotterie, A. Benouaich-Amiel, E. Uro-Coste, V. Lubrano, E. Cohen-Jonathan Moyal   +8 more
openaire   +3 more sources

TTNPB Promotes Human Pluripotent Stem Cell‐to‐Neural Stem Cell Transition via Modulation of Chromatin Accessibility and the S‐(5′‐adenosyl)‐L‐homocysteine/Choline Metabolic Network

Advanced Science, EarlyView.
A retinoic acid receptor agonist, TTNPB, drives the efficient generation of advanced neural stem cells (ANSCs) from human pluripotent stem cells. TTNPB‐centered chromatin remodeling and metabolic reprogramming, promote neuroectoderm commitment. The resulting cells show robust neural potential and functional efficacy in a rat depression model.
Ruilin Du, Yudi Ren, Qiaoqiao Meng, Peng Wei, Ruyu Zhu, Junjie Bao, Ye Yang, Shuo Yan, Chaorong Yue, Xueying Zhu, Shuo Cao, Chunxia Hao, Wei Sun, Yongli Song, Xihe Li, Zhimin Wu, Siqin Bao, Yanglin Chen   +17 more
wiley   +1 more source