Results 51 to 60 of about 21,681 (186)

Subventricular zone lipidomic architecture loss in Huntington's disease [PDF]

Journal of Neurochemistry, 2018
AbstractThe human subventricular zone (SVZ) has a defined cytological and neurochemical architecture, with four constituent laminae that act in concert to support its neurogenic activity. Lipidomic specialisation has previously been demonstrated in the neurologically normal human SVZ, with enrichment of functionally important lipid classes in each ...
Mandana Hunter, Nicholas J. Demarais, Richard L. M. Faull, Angus C. Grey, Maurice A. Curtis   +4 more
openaire   +2 more sources

Mesenchymal/proangiogenic factor YKL-40 related to glioblastomas and its relationship with the subventricular zone

Folia Neuropathologica, 2017
Glioblastoma is the most common primary brain tumor. Despite multimodality therapy with aggressive microsurgical resection and adjuvant chemotherapy and radiotherapy, the median survival is below 15 months.
Kelvin M. Pińa Batista, Sayoa Alvarez de Eulate-Beramendi, Kenia Y. Álvarez Reyes de Pińa, Pedro Reimunde Figueira, Adan Fernandez Canal, Josué M. Avecillas Chasin, Ángela Meilan, Rodrigo Ugalde, Ivan Fernandez Vega   +8 more
doaj   +1 more source

Islet Amyloid Polypeptide Modelled to Simulate Diabetes Co‐Oligomerized with β‐Amyloid 1‐42 Reproducing the Pathological Cascade of Alzheimer's Disease in Human Cerebral Organoids

Advanced Science, EarlyView.
Human islet amyloid polypeptide (hIAPP) was used to mimic T2DM, and Aβ42‐hIAPP co‐oligomers were delivered into the human mature cerebral organoids (COs), which reproduce typical AD pathology and significant neuronal death more closely resembling that of AD patients.
Jin Yan, Zhimeng Tang, Yanyu Luo, Bin Liu, Xinxin Huang, Jun Wei, Feng Yue   +6 more
wiley   +1 more source

A model of ischemia-induced neuroblast activation in the adult subventricular zone. [PDF]

PLoS ONE, 2009
We have developed a rat brain organotypic culture model, in which tissue slices contain cortex-subventricular zone-striatum regions, to model neuroblast activity in response to in vitro ischemia.
Davide Vergni, Filippo Castiglione, Maya Briani, Silvia Middei, Elena Alberdi, Klaus G Reymann, Roberto Natalini, Cinzia Volonté, Carlos Matute, Fabio Cavaliere   +9 more
doaj   +1 more source

From the Gut to the Brain: Microplastic‐Associated Neurovascular Dysfunction and Implications for Stroke Risk

Advanced Science, EarlyView.
Chronic oral exposure to microplastics may disrupt gut microbiota homeostasis and intestinal barrier integrity, potentially engaging the gut–brain axis and systemic inflammatory responses. These alterations may be associated with impaired blood–brain barrier function, cerebral microvascular dysfunction, and enhanced endothelial inflammation, pro ...
Hongxing Wang, Yujiao He, Pei Zou, Xiaoyi Wang, Gang Peng, Xiangying Deng   +5 more
wiley   +1 more source

MicroRNA-124 Is a Subventricular Zone Neuronal Fate Determinant [PDF]

Journal of Neuroscience, 2012
New neurons are continuously generated from neural stem cells with astrocyte properties, which reside in close proximity to the ventricle in the postnatal and adult brain. In this study we found that microRNA-124 (miR-124) dictates postnatal neurogenesis in the mouse subventricular zone. Using a transgenic reporter mouse we show that miR-124 expression
Åkerblom, Malin, Sachdeva, Rohit, Barde, Isabelle, Verp, Sonia, Gentner, Bernhard, Trono, Didier, Jakobsson, Johan   +6 more
openaire   +4 more sources

Potentials of Endogenous Neural Stem cells in Cortical Repair

Frontiers in Cellular Neuroscience, 2012
In the last few decades great thrust has been put in the area of regenerative neurobiology research to combat brain injuries and neurodegenerative diseases.
Bhaskar eSaha, Mohamed eJaber, Afsaneh eGaillard   +2 more
doaj   +1 more source

Unveiling a New Link: Cholesterol Deficiency in Smith–Lemli–Opitz and Niemann–Pick C as a Driver of Ciliopathies

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT The ciliopathies are a group of genetic disorders caused by defective function of either the primary cilia (a large number) or the motile cilia (a much smaller number). These have been defined as diseases with mutations in genes encoding individual ciliary or cilia‐associated proteins.
Robert P. Erickson, Maria Teresa Fiorenza   +1 more
wiley   +1 more source

Silk fibroin‐based biomaterials for spinal cord injury repair: Recent advances and future prospects

BMEMat, EarlyView.
A comprehensive review on the design principles and current strategies of silk fibroin‐based biomaterials in spinal cord injury repair, focusing on environmentally friendly processing techniques, and the strategies for designing composite scaffolds as well as discussing the advantages and current challenges of silk fibroin‐based biomaterials in spinal ...
Xiaoliang Cui, Xuanwen Wang, Siying Liu, Lilei Wang, Menghong Li, Jun Zhang, Li Wang, Ke‐Qin Zhang   +7 more
wiley   +1 more source

Tissue Engineering and Biomaterial Strategies to Elicit Endogenous Neuronal Replacement in the Brain

Frontiers in Neurology, 2020
Neurogenesis in the postnatal mammalian brain is known to occur in the dentate gyrus of the hippocampus and the subventricular zone. These neurogenic niches serve as endogenous sources of neural precursor cells that could potentially replace neurons that
Erin M. Purvis, Erin M. Purvis, John C. O'Donnell, John C. O'Donnell, H. Isaac Chen, H. Isaac Chen, D. Kacy Cullen, D. Kacy Cullen, D. Kacy Cullen   +8 more
doaj   +1 more source