Results 81 to 90 of about 21,681 (186)

Stroke Repair via Biomimicry of the Subventricular Zone

Frontiers in Materials, 2018
Stroke is among the leading causes of death and disability worldwide, 85% of which are ischemic. Current stroke therapies are limited by a narrow effective therapeutic time and fail to effectively complete the recovery of the damaged area.
Rita Matta, Anjelica L. Gonzalez
doaj   +1 more source

Modeling cerebral palsy in animals

Developmental Medicine &Child Neurology, Volume 68, Issue 2, Page 158-174, February 2026.
Abstract Advancements in the treatment of cerebral palsy depend on animal research. Yet, most animal models have not been fully evaluated for spasticity and dystonia using clinically relevant measures of altered tone or movement patterns, which form the basis for diagnosing people with the condition.
Katharina A. Quinlan, Emily J. Reedich, Elvia Mena Avila, Brendan C. Moline, Landon T. Genry, Megan R. Detloff, Benjamin R. Katholi, Deborah Gaebler‐Spira, Bhooma R. Aravamuthan   +8 more
wiley   +1 more source

On the subventricular zone origin of human glioblastoma

Translational Cancer Research, 2019
The cancer stem cell theory posits that a small subset of cancer cells with self-renewing capacity, popularly known as cancer stem cells and experimentally defined as tumor-initiating cells, maintains the tumor with its heterogeneous lineages of cancer cells (1,2).
openaire   +2 more sources

Chi3l3 induces oligodendrogenesis in an experimental model of autoimmune neuroinflammation

Nature Communications, 2019
Chitinase 3-like-3 (Chi3l3) is expressed in microglia, but its function is not clear. Here the authors show that Chi3l3 is expressed in the subventricular zone in mouse experimental immune encephalitis, which induces oligodendrogenesis.
Sarah C. Starossom, Juliana Campo Garcia, Tim Woelfle, Silvina Romero-Suarez, Marta Olah, Fumihiro Watanabe, Li Cao, Ada Yeste, John J. Tukker, Francisco J. Quintana, Jaime Imitola, Franziska Witzel, Dietmar Schmitz, Markus Morkel, Friedemann Paul, Carmen Infante-Duarte, Samia J. Khoury   +16 more
doaj   +1 more source

Perlecan is required for FGF-2 signaling in the neural stem cell niche

Stem Cell Research, 2014
In the adult subventricular zone (neurogenic niche), neural stem cells double-positive for two markers of subsets of neural stem cells in the adult central nervous system, glial fibrillary acidic protein and CD133, lie in proximity to fractones and to ...
Aurelien Kerever, Frederic Mercier, Risa Nonaka, Susana de Vega, Yuka Oda, Bernard Zalc, Yohei Okada, Nobutaka Hattori, Yoshihiko Yamada, Eri Arikawa-Hirasawa   +9 more
doaj   +1 more source

Ethanol Alters DNMT1/3a/3b Expression Profile, Promotes Persistent DNA Hypomethylation in Human Brain Endothelial Cells and Impairs Late Cortical Angiogenesis

Journal of Neurochemistry, Volume 170, Issue 2, February 2026.
Ethanol exposure alters brain endothelial cell function and blood–brain barrier integrity. In human brain microcapillary endothelial cells (HBMEC) and mouse brain endothelial cells (MBEC) from a prenatal alcohol exposure (PAE) model, ethanol increased DNA methyltransferas‐1 (DNMT1) activity and reduced DNA methylation, affecting DNMT3a/3b, methyl‐CpG ...
Michele Siqueira, Matheus Barros, Paula Lacerda Almeida, Luiza dos Santos Heringer, Henrique Rocha Mendonça, Flávia Carvalho Alcantara Gomes, Joice Stipursky   +6 more
wiley   +1 more source

RBM3 promotes neurogenesis in a niche-dependent manner via IMP2-IGF2 signaling pathway after hypoxic-ischemic brain injury

Nature Communications, 2019
Therapeutic hypothermia is a potent tool in the treatment of neonatal hypoxic-ischemic (HI) injury, yet the underlying mechanisms remain unclear. Here, authors demonstrate how the RNA-binding motif protein RBM3, which is induced by mild cooling while ...
Xinzhou Zhu, Jingyi Yan, Catherine Bregere, Andrea Zelmer, Tessa Goerne, Josef P. Kapfhammer, Raphael Guzman, Sven Wellmann   +7 more
doaj   +1 more source

Catalpol promotes the generation of cerebral organoids with oRGs through activation of STAT3 signaling

Bioengineering & Translational Medicine
The generation of human cortical organoids containing outer radial glia (oRG) cells is crucial for modeling neocortical development. Here we show that Catalpol, an iridoid glucoside derived from Rehmannia glutinosa, significantly enhances the generation ...
Yoo‐Jung Lee, Byounggook Cho, Daeyeol Kwon, Yunkyung Kim, Saemin An, Soi Kang, Jongpil Kim   +6 more
doaj   +1 more source

Activation of subventricular zone stem cells after neuronal injury

Cell and Tissue Research, 2007
The mammalian subventricular zone (SVZ) has garnered a tremendous amount of attention as a potential source of replacement cells for neuronal injury. This zone is highly neurogenic, harbours stem cells and supports long-distance migration. The general pattern of activation includes increased proliferation, neurogenesis and emigration towards the injury.
Kim, Y, Szele, F
openaire   +3 more sources

What do we know about adult mammalian hippocampal neurogenesis so far? [PDF]

Medicinski Podmladak
It is known that the adult mammalian brain can add new neurons throughout the whole lifespan. Neural stem cells reside in the subgranular zone of the dentate gyrus of the hippocampus and the subventricular zone of the rostral lateral ventricle.
Jeremić Rada, Brkić Predrag, Dacić Sanja   +2 more
doaj   +1 more source