Results 141 to 150 of about 215,979 (293)

Adss1–HDAC3 Interaction: A Novel Mechanism for Epigenetic Regulation of Metabolism in Adipose Tissue

iNew Medicine, EarlyView.
ABSTRACT Obesity and its related metabolic disorders have emerged as global public health challenges with underlying mechanisms involving an imbalance between energy storage and expenditure in the adipose tissue. In recent years, with the deepening research on adipose tissue metabolism, the cross talk between metabolic enzymes and epigenetic regulation
Jiarui Zhao, Jingjing Sun, Yan Lu, Ying Yang   +3 more
wiley   +1 more source

Non‐invasive and efficient diabetic retinal mitochondrial repair nanoplatform based on engineered endothelial mitochondrial‐derived vesicles with dynamic integrated stress response modulation

Interdisciplinary Medicine, EarlyView.
Under hyperglycemic conditions, mitochondrial dysfunction in retinal endothelial cells triggers excessive reactive oxygen species/reactive nitrogen species production, barrier protein degradation, and endothelial barrier breakdown in diabetic retinopathy.
Siyu Gui, Jie Gao, Tianchang Tao, Peng Wang, Zhihao Huang, Yuyang She, Jiajie Li, Jingwan Su, Zhe Lu, Jianchao Qiao, Song Wang, Xiaodong Sun, Mohan Li   +12 more
wiley   +1 more source

Gut microbiome‐derived metabolites show promise in cancer research and therapy

Interdisciplinary Medicine, EarlyView.
The metabolites produced by the gut microbiome, which are subject to regulation by multiple factors, play a pivotal role in the progression of various types of cancer. These metabolites not only function as potential biomarkers for the early detection and monitoring of tumor development, but also actively participate in cancer therapeutic processes ...
Kangjie Yang, Yifan Wang, Daolin Tang, Peilong Li, Lutao Du   +4 more
wiley   +1 more source

Monocytes with trained immunity–like signatures are associated with acute anterior uveitis in ankylosing spondylitis

Interdisciplinary Medicine, EarlyView.
In ankylosing spondylitis‐acute anterior uveitis (AS‐AAU), trained immunity monocytes (Mono‐TI) differentiate into macrophages in the eye, retaining trained immunity features. Mono‐TI cells secrete pro‐inflammatory cytokines and chemokines, including IL‐1β, TNF‐α, and CCL3.
Yimeng Sun, Lu Zhang, Xinyu Yao, Yunfei Liu, Xin Li, Feng Wen, Yong Dai, Ye Dai, Ziyu Du, Dijie Qiao, Ziwei Meng, Cong Hu, Chun Yan, Wei Chi   +13 more
wiley   +1 more source

Chronic Low‐Dose Unsymmetrical Dimethylhydrazine Exposure in Rats: Multiorgan Mechanisms and Biomarker Identification

Journal of Applied Toxicology, EarlyView.
ABSTRACT Unsymmetrical dimethylhydrazine (UDMH), a highly toxic rocket propellant with known multiorgan effects, requires urgent characterization of its chronic low‐dose toxicity. Using an integrated approach including exploratory transcriptomics (n = 3/group) and metabolomic (n = 4/group) approaches in male Sprague–Dawley rats exposed to high‐dose ...
Fuzhou Liu, Bing Liu, Keli Wang, Xiaoyu Wang, Zhen Sun, Xiaojuan Pan, Zengming Zhao   +6 more
wiley   +1 more source

Influence of genetic diversity, drought stress and rhizobial symbiosis on the nutritional quality of common vetch (Vicia sativa L.) grain

Journal of the Science of Food and Agriculture, EarlyView.
Abstract BACKGROUND Legumes are the primary source of plant protein in both human and livestock diets and, therefore, play an essential role in nutrition. Common vetch (Vicia sativa L.) is a grain legume widely used in animal feed. Its nutritional properties, particularly its high protein content, make it an adequate component to enrich feedstuffs ...
María Isabel López‐Román, Lucía De la Rosa, Cristina Castaño‐Herrero, Maria Teresa Marcos‐Prado, Elena Ramírez‐Parra   +4 more
wiley   +1 more source

Enzymatic Ring‐Opening Polymerization of ε‐Caprolactone in Novel Green Solvents: from Batch Systems to Continuous Flow Mesoreactors

Macromolecular Materials and Engineering, EarlyView.
Multi‐gram synthesis of CaLB‐catalyzed ROP of ε‐CL in green organic media under flow conditions. ABSTRACT The transition toward sustainable alternatives in polymeric material production is a critical step in reducing the environmental impact of the traditional plastic industry.
Tullio Crovetto, Andrea Pasquale, Daniele Alessandro Consolini, Martina Letizia Contente, Alessandro Pellis   +4 more
wiley   +1 more source

Successive Mechanical Recycling of Poly(lactic Acid) by Injection Molding: Evolution of Molecular, Thermal, and Mechanical Properties

Macromolecular Materials and Engineering, EarlyView.
This study investigated how successive injection molding recycling affects the properties of poly(lactic acid) (PLA). Gel permeation chromatography showed a two‐thirds molar mass reduction after ten reprocessing cycles. Differential scanning calorimetry revealed lower glass transition and cold crystallization temperatures.
László Lendvai, Virág Luca Bódi, Martin Danko, Petar Sabev Varbanov, Sándor Kálmán Jakab   +4 more
wiley   +1 more source

Clinical and laboratory evaluation of the efficiency of chronic hemodialysis treatment using acidosuccinate in patients with terminal renal failure

Терапевтический архив, 2013
AIM: To evaluate the efficiency of using a succinate-containing dialysis solution (SCDS) in terminal renal failure patients treated with chronic hemodialysis (CHD)/MATERIAL AND METHODS: Ninety patients from two hemodialysis units took part in the ...
A V Smirnov, O B Nesterova, E D Suglobova, R V Golubev, A N Vasil'ev, I A Vasil'eva, E V Verbitskaia, N Iu Korosteleva, E M Kostereva, É B Lebedeva, E N Levykina, K G Starosel'skiĭ, V A Lazeba   +12 more
doaj  

Mono‐ and Bivalent Poly(iso‐butylene)‐Alanines for Drug‐Delivery of Nimodipine and Triamcinolone Acetonide

Macromolecular Rapid Communications, EarlyView.
Mono‐ and bivalent‐, alanine‐modified poly‐iso‐butylenes, folding into beta‐sheets, were prepared by living carbocationic polymerization and subsequent endgroup modification. These PIB‐conjugates are useful as solid polymers for the drug release of triamcinolone and nimodipine. ABSTRACT Poly‐iso‐butylene (PIB) is a well known biocompatible polymer with
Philipp S. Hilgeroth, Julius F. Butter, Wolfgang H. Binder   +2 more
wiley   +1 more source