Results 271 to 280 of about 382,582 (334)

Transforming Growth Factor‐β‐Mediated Fibrotic Remodeling Drives Chronic Kidney Disease in Methylmalonic Aciduria and Propionic Aciduria—Identification of a New Therapeutic Target

Journal of Inherited Metabolic Disease, Volume 48, Issue 6, November 2025.
ABSTRACT Propionic aciduria (PA‐uria) and methylmalonic aciduria (MMA‐uria) are caused by defects in propionate catabolism. While chronic kidney disease (CKD) is a well‐established complication in MMA‐uria, renal involvement in PA‐uria has only come into focus more recently, and the underlying mechanisms remain poorly understood.
Karina A. Zeyer, Stefan Tholen, Oliver Schilling, Leonie Gerling, Marina Morath, Stefan Kölker, Alexander Nyström, Ute Spiekerkoetter, Anke Schumann   +8 more
wiley   +1 more source

A Comprehensive Review of Germination Impact on Moringa Seeds and Sprouts: Physiological and Biochemical Changes, Bioactive Compounds, Health Benefits, and Food Applications

Comprehensive Reviews in Food Science and Food Safety, Volume 24, Issue 6, November 2025.
ABSTRACT Germination is emerging as a promising bioprocess to produce edible moringa sprouts with enhanced nutritional value and health benefits. Germinated moringa seeds could be marketed as a novel food ingredient for functional food formulations. Attempts to understand the bioactive compounds and their associated health benefits of moringa seeds and
Yi Liu, Yi Kai, Dejian Huang, Shao Quan Liu, Yuyun Lu   +4 more
wiley   +1 more source

β-Cyclodextrin-optimized supramolecular nanovesicles enhance the droplet/foliage interface interactions and inhibition of succinate dehydrogenase (SDH) for efficient treatment of fungal diseases. [PDF]

J Nanobiotechnology
Guo DX, Song L, Yang JH, He XY, Liu P, Wang PY.   +5 more
europepmc   +1 more source

Differences in Clinical Presentation Between Pheochromocytomas and Paragangliomas

Clinical Endocrinology, Volume 103, Issue 5, Page 651-658, November 2025.
ABSTRACT Objectives Pheochromocytomas and sympathetic paragangliomas (PPGLs) are similar in most aspects. However, they differ in genetic etiology, hormonal secretion, and associated neoplasms. This study aimed to investigate differences in clinical presentation between PPGLs. Design This study employs a retrospective cohort design. Patients The cohort
Vincent E. D. Pihlblad, Jan Calissendorff, Henrik Falhammar   +2 more
wiley   +1 more source

Uterine Leiomyomas with Specific Histology Features of Two Fumarate Hydratase/Succinate Dehydrogenase-Deficient Tumors: A Double Case Report. [PDF]

Medicina (Kaunas)
Jovanović L, Milenković S, Andrić L, Stefanović R, Milošević B, Micić J, Pilić I, Beleslin A, Mihaljević O, Dokić M.   +9 more
europepmc   +1 more source

The Role of C/EBP‐Homologous Protein in Idiopathic Inflammatory Myopathies

Journal of Cellular and Molecular Medicine, Volume 29, Issue 21, November 2025.
ABSTRACT The Idiopathic Inflammatory Myopathies (IIMs) are a group of autoimmune disorders characterised by persistent muscle inflammation and diverse clinical manifestations. Common symptoms include muscle weakness, myalgia, and elevated serum creatine kinase levels. Recent findings highlight the relevance of muscle fibre necrosis in IIMs.
Monica Sciacco, Patrizia Ciscato, Letizia Bertolasi, Maria Guttuso, Stefania Corti, Deborah Mattinzoli, Masami Ikeata, Giuseppe Castellano, Giacomo Pietro Comi, Simona Zanotti   +9 more
wiley   +1 more source

A highly malignant succinate dehydrogenase A‑deficient renal cell carcinoma with bone metastasis misdiagnosed as hereditary leiomyomatosis and renal cell carcinoma: A case report. [PDF]

Oncol Lett
Dai Z, Wang X, Zhang Y, Qiu Y, Liu J.
europepmc   +1 more source

Complementary Muscle Metabolomics and Proteomics of Muscle in Cows With Post‐Calving Ketosis

Journal of Veterinary Internal Medicine, Volume 39, Issue 6, November/December 2025.
ABSTRACT Background The muscle tissue of dairy cows is a site of β‐hydroxybutyrate (BHBA) metabolism. The mechanisms underlying the changes in proteins and metabolites in the muscle tissue of cows with ketosis remain unclear. Objectives To elucidate the metabolic and physiological molecular adaptation mechanisms in the muscle tissue of cows with ...
Tao Tang, Jing Zhou, Jiahao Shao, Meigui Wang, Siqi Xia, Wenqiang Sun, Xianbo Jia, Jie Wang, Songjia Lai   +8 more
wiley   +1 more source

Inhibition of rhizobial cheaters by the host Medicago truncatula involves repression of symbiotic functions and induction of defense

New Phytologist, Volume 248, Issue 3, Page 1458-1474, November 2025.
Summary In symbiotic plant–microbe interactions, the host invests considerable amounts of resources in the microbial partner. If the microbe does not reciprocate with a comparable symbiotic benefit, it is regarded as a cheater. The host responds to cheaters with negative feedback mechanisms (sanctions) to prevent fitness deficits resulting from being ...
Min Chen, Axelle Raisin, Natalie Judkins, Pierre‐Marie Allard, Emmanuel Défossez, Michael Stumpe, Inmaculada Yruela, Manuel Becana, Didier Reinhardt   +8 more
wiley   +1 more source

Long-Term Protective Effects of Succinate Dehydrogenase Inhibition during Reperfusion with Malonate on Post-Infarction Left Ventricular Scar and Remodeling in Mice. [PDF]

Int J Mol Sci
Valls-Lacalle L, Consegal M, Ganse FG, Yáñez-Bisbe L, Pastor J, Ruiz-Meana M, Inserte J, Benito B, Ferreira-González I, Rodríguez-Sinovas A.   +9 more
europepmc   +1 more source