Results 51 to 60 of about 38,608 (234)

Beyond PEG: Emerging Polymer Lipid Alternatives for Lipid Nanoparticle (LNP) Formulations

Advanced Science, EarlyView.
This review discusses recent advances in PEG‐alternative LNP designs, including non‐PEG polymers, zwitterionic lipids, and polypeptides. It evaluates how surface‐engineering chemistry influences LNP formation and biological behavior, and highlights current limitations and opportunities of PEG‐alternative LNPs.
Zihnil A. I. Mazrad, Yi Ju, Stephen J. Kent, Colin W. Pouton, Kristian Kempe   +4 more
wiley   +1 more source

From Flexible to Conformable Pressure Sensors: Mechanisms, Materials, and Biomedical Applications

Advanced Electronic Materials, EarlyView.
This review highlights recent progress, challenges and future opportunities in pressure sensing for advanced biomedical applications. We summarize key transduction mechanisms and emerging material strategies, discuss representative wearable and implantable applications for continuous physiological monitoring and provide a focused perspective on barrier
Rishabh B. Mishra, Andrea Ottomaniello, Virgilio Mattoli   +2 more
wiley   +1 more source

Deoxydehydration and Catalytic Transfer Hydrogenation: New Strategy to Valorize Tartaric Acid and Succinic Acid to γ-Butyrolactone and Tetrahydrofuran

Energies, 2020
Hydrogenation of succinic acid and maleic acid produces C4 value-added chemicals such as γ-butyrolactone and tetrahydrofuran. Here, unsupported ReOx nanoparticles transform succinic acid to γ-butyrolactone and tetrahydrofuran via catalytic transfer ...
Jun Hee Jang, Mahdi M. Abu-Omar
doaj   +1 more source

Citric‐Acid Polyester‐Modified Melamine–Formaldehyde Resins: Mechanistic Insights and Implications for Greener Decorative Laminates

Journal of Applied Polymer Science, EarlyView.
Driven by the need for more sustainable materials in the laminate industry, poly(glycerol citrate) was introduced as a bio‐based modifier that significantly altered the cure kinetics and structural evolution of melamine–formaldehyde resins. Correlated FTIR, DSC, TGA, and rheological analyses revealed accelerated network formation, enabling lower ...
Martina Duller, Arunjunai Raj Mahendran, Elisabeth Billich, Edith Martha Zikulnig‐Rusch   +3 more
wiley   +1 more source

Liquid‐phase oxidation of furfural catalyzed by magnetically separable metal oxide nanoparticles deposited on silica gel

Biofuels, Bioproducts and Biorefining, EarlyView.
Abstract Oxidation of furfural (FF), a bio‐based platform chemical, was investigated using a range of iron‐, vanadium‐ and iron–zinc‐oxalates supported on silica gel (FeVOx@silica and FeZnOx@silica, respectively) as precursor for FeV@silica and FeZn@silica oxide catalysts and H2O2 as a green oxidant.
Alexander Pokutsa, Alina Mariana Balu, Rafael Luque   +2 more
wiley   +1 more source

Metabolic Flux Analysis Reveals Cell Line‐Specific Rewiring in CHO Cells Following TCA Cycle Intermediate Feeding for Bioprocess pH Control

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Chinese hamster ovary (CHO) cells are the leading host for recombinant therapeutic protein production in the biopharma industry. In this study, we investigated how feeding acidic forms of tricarboxylic acid (TCA) cycle intermediates—malic acid, succinic acid, and α‐ketoglutaric acid—affects cell culture performance and metabolism in two ...
Sarah A. Sacco, Kevin J. Ruiz‐Márquez, Rachel Moen, Irina Trenary, Xiaolin Zhang, Xiaowen Wang, Malik Padellan, Henry Lin, Jamey D. Young   +8 more
wiley   +1 more source

Eudragit®‐engineered pH‐responsive probiotic microspheres with enhanced gastrointestinal resistance and prolonged storage stability for inflammatory bowel disease therapy

BMEMat, EarlyView.
This study reports the development of AMS@Eud core‐shell microspheres, combining calcium alginate and pH‐responsive Eudragit® L100, which exhibit exceptional gastrointestinal resistance and long‐term storage stability (only 5.28%–9.09% viability loss over 35 days at 4–25°C), and effectively alleviate inflammatory bowel disease via gut microbiota ...
Ming Teng, Xiaomin Luo, Peng Zhang, Chen Yang, Yuniel Ma, Xinhua Liu   +5 more
wiley   +1 more source

Biotechnological Synthesis of Succinic Acid By Actinobacillus succinogenes by Exploitation of Lignocellulosic Biomass

Chemical Engineering Transactions, 2017
Succinic acid is increasingly used in pharmaceutical industries, for the production of additives in food industries, in agriculture and in refinery processes as a precursor of many chemical compounds among which the most important is the succinate salt ...
D. Pirozzi, M. Fagnano, N. Fiorentino, G. Toscano, F. Rugari, F. Sannino, G. Zuccaro, C. Florio   +7 more
doaj   +1 more source

Homo‐/Heterodimeric Substrates Bias the Type and Multiplicity of Hydroxamic Acid Chelators Assembled by a NIS Synthetase DesD

Chemistry – A European Journal, EarlyView.
Chemoenzymatic reactions using the siderophore synthetase DesD from Salinispora tropica and hydroxamic acid substrates (native, non‐native) with different multiplicities (monomer, dimer) and components (homo‐/heterodimer) followed different reaction trajectories, which biased the architectures of the chelator major products and indicated DesD contains ...
Callum A. Rosser, Todd E. Markham, Rachel Codd   +2 more
wiley   +1 more source

Extracellularly Activatable Conjugates of RGD Peptidomimetics and Cryptophycin for αVβ3‐Targeted Cancer Therapy

Chemistry – A European Journal, EarlyView.
Integrin αVβ3‐targeting small‐molecule drug conjugates (SMDCs) were synthesized by conjugating a cryptophycin payload through a neutrophil elastase‐cleavable NPV‐PABC linker. RGD peptidomimetic and linker epimers served as controls for targeting and enzymatic cleavage, and the resulting conjugates displayed subnanomolar cytotoxicity in vitro.
Dominic Seißenschmidt, Henriette Hartung, Jonah Kammer, Norbert Sewald   +3 more
wiley   +1 more source