Results 31 to 40 of about 38,608 (234)

Succinic acid inhibits the activity of cytochrome P450 (CYP450) enzymes

Pharmaceutical Biology, 2020
Context Succinic acid, extracted from amber, is widely used in cardiovascular therapy. Objective The effect of succinic acid on the activity of cytochrome P450 (CYP450) enzymes was investigated in this study.
Hao Wang, Bingyan Xia, Mei Lin, Yongpeng Wang, Bin Sun, Yuzhu Li   +5 more
doaj   +1 more source

Co-production of acetoin and succinic acid by metabolically engineered Enterobacter cloacae

Biotechnology for Biofuels, 2021
Background Renewable chemicals have attracted attention due to increasing interest in environmental concerns and resource utilization. Biobased production of industrial compounds from nonfood biomass has become increasingly important as a sustainable ...
Hsiang-Yen Su, Hua-Ying Li, Cai-Yun Xie, Qiang Fei, Ke-Ke Cheng   +4 more
doaj   +1 more source

Hydrolysis of lignocellulose to succinic acid: a review of treatment methods and succinic acid applications

Biotechnology for Biofuels and Bioproducts, 2023
AbstractSuccinic acid (SA) is an intermediate product of the tricarboxylic acid cycle (TCA) and is one of the most significant platform chemicals for the production of various derivatives with high added value. Due to the depletion of fossil raw materials and the demand for eco-friendly energy sources, SA biosynthesis from renewable energy sources is ...
Shuzhen Zhou, Miaomiao Zhang, Linying Zhu, Xiaoling Zhao, Junying Chen, Wei Chen, Chun Chang   +6 more
openaire   +3 more sources

Thermodynamic and Thermomicroscopy Study of Atorvastatin Calcium-Succinic Acid Binary Mixtures

Indonesian Journal of Chemistry, 2017
Binary mixtures of pharmaceuticals significantly affect the physical and chemical properties of each component. The aim of this work was to explore the thermal behavior and solid state transformation of binary mixture of atorvastatin calcium and succinic
Yudi Wicaksono, Budipratiwi Wisudyaningsih, Frida Oktaningtias Widiarthi, Tri Agus Siswoyo   +3 more
doaj   +1 more source

Baltic amber teething necklaces: could succinic acid leaching from beads provide anti-inflammatory effects?

BMC Complementary and Alternative Medicine, 2019
Background Baltic amber teething necklaces have been popularized as a safe and natural alternative to conventional or pharmacological medicines for the management of teething pain. However, claims made by retailers regarding the efficacy and mechanism of
Michael D. Nissen, Esther T. L. Lau, Peter J. Cabot, Kathryn J. Steadman   +3 more
doaj   +1 more source

Sustainable and Multifunctional Natural Macromolecular Polymers for Aqueous Zn Metal Batteries

Advanced Materials, EarlyView.
We comprehensively review the structure‐function relationships and regulatory mechanism of natural macromolecular polymers in stabilizing zinc anodes at the microscopic and mesoscopic scales. The interactions among polymer structures, optimization strategies, and regulatory mechanisms are discussed systematically summarizing recent related research ...
Yunuo Shi, Bo Jiang, Jingcheng Zhang, Xiaodong Shao, Peixun Xiong, Lutong Shan, Shengyang Huang, Mengfang Liang, Mengyao Chang, Fangyan Liu, Wenwu Li, Baoyu Xia, Wei Ji, Ho Seok Park   +13 more
wiley   +1 more source

Bis(melaminium) succinate succinic acid monosolvate dihydrate [PDF]

Acta Crystallographica Section E Structure Reports Online, 2012
The asymmetric unit of the solvated title salt, 2C3H7N6+·C4H4O42−·C4H6O4·2H2O, contains one essentially planar melaminium (2,4,6-triamino-1,3,5-triazin-1-ium) cation (r.m.s. deviation of the non-H atoms = 0.0097 Å), one-half of a succinate anion, one-half of a succinic acid solvent molecule and one water molecule of crystallization; full molecules are ...
Barbara Froschauer, Matthias Weil
openaire   +3 more sources

Protein Structuromics Reveals a Loop‐Controlled Half‐Open Active Pocket Conformation Throughout Fe(II)/α‐ketoglutarate‐Dependent Dioxygenase Catalytic Cycle

Advanced Science, EarlyView.
This study reveals a conserved half‐open active pocket in Fe(II)/α‐ketoglutarate‐dependent dioxygenases through protein structuromics, distinguished by structural features comprising highly flexible loop elements. Enhanced sampling simulations‐guided mutagenesis experiments elucidated how this flexible loop regulates pocket open/closed conformations ...
Lunjie Wu, Huan Liu, Songyin Zhao, Lei Qin, Jiarui Li, Jun Wang, Zixuan Dai, Jie Gu, Yan Xu, Feiran Li, Yao Nie   +10 more
wiley   +1 more source

Improved succinic acid production through the reconstruction of methanol dissimilation in Escherichia coli

Bioresources and Bioprocessing, 2022
Synthetic biology has boosted the rapid development on using non-methylotrophy as chassis for value added chemicals production from one-carbon feedstocks, such as methanol and formic acid.
Feng Guo, Min Wu, Shangjie Zhang, Yifan Feng, Yujia Jiang, Wankui Jiang, Fengxue Xin, Wenming Zhang, Min Jiang   +8 more
doaj   +1 more source

Vascularized Liver‐on‐a‐Microsphere Reveals Alanine‐Glucose Metabolism‐Driven Regulation of Liver Function and Injury

Advanced Science, EarlyView.
A vascularized liver‐on‐a‐microsphere system is developed to recreate lobule‐like cellular organization and endothelial barrier function within compartmentalized hydrogel particles. The platform enhances hepatic performance and reveals alanine‐glucose cycle activation linked to improved detoxification capacity, offering a high‐throughput microscale ...
Jingyang Li, Zengnan Wu, Yingrui Zhang, Shulang Chen, Yongning Lin, Shiyu Chen, Tong Xu, Xianli Meng, Yi Zhang, Jin‐Ming Lin   +9 more
wiley   +1 more source