Results 1 to 10 of about 9,709 (198)

Ten-Week Sucralose Consumption Induces Gut Dysbiosis and Altered Glucose and Insulin Levels in Healthy Young Adults

Microorganisms, 2022
Sucralose consumption alters microbiome and carbohydrate metabolism in mouse models. However, there are no conclusive studies in humans. Our goals were to examine the effect of sucralose consumption on the intestinal abundance of bacterial species ...
Lucía A. Méndez-García, Nallely Bueno-Hernández, Miguel A. Cid-Soto, Karen L. De León, Viridiana M. Mendoza-Martínez, Aranza J. Espinosa-Flores, Miguel Carrero-Aguirre, Marcela Esquivel-Velázquez, Mireya León-Hernández, Rebeca Viurcos-Sanabria, Alejandra Ruíz-Barranco, Julián M. Cota-Arce, Angélica Álvarez-Lee, Marco A. De León-Nava, Guillermo Meléndez, Galileo Escobedo   +15 more
doaj   +2 more sources

Sucralose: From Sweet Success to Metabolic Controversies—Unraveling the Global Health Implications of a Pervasive Non-Caloric Artificial Sweetener

Life
Sucralose is a food additive initially used to mitigate glycemic peaks and calorie intake in patients with diabetes and obesity. Although sucralose has been considered safe for human consumption, the World Health Organization (WHO) issued a global alert ...
José Alfredo Aguayo-Guerrero, Lucía Angélica Méndez-García, Helena Solleiro-Villavicencio, Rebeca Viurcos-Sanabria, Galileo Escobedo   +4 more
doaj   +2 more sources

Newborns from Mothers Who Intensely Consumed Sucralose during Pregnancy Are Heavier and Exhibit Markers of Metabolic Alteration and Low-Grade Systemic Inflammation: A Cross-Sectional, Prospective Study

Biomedicines, 2023
Robust data in animals show that sucralose intake during gestation can predispose the offspring to weight gain, metabolic disturbances, and low-grade systemic inflammation; however, concluding information remains elusive in humans.
José Alfredo Aguayo-Guerrero, Lucía Angélica Méndez-García, Aarón Noe Manjarrez-Reyna, Marcela Esquivel-Velázquez, Sonia León-Cabrera, Guillermo Meléndez, Elena Zambrano, Espiridión Ramos-Martínez, José Manuel Fragoso, Juan Carlos Briones-Garduño, Galileo Escobedo   +10 more
doaj   +2 more sources

Sucralose, a Non-nutritive Artificial Sweetener Exacerbates High Fat Diet-Induced Hepatic Steatosis Through Taste Receptor Type 1 Member 3

Frontiers in Nutrition, 2022
Non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disease globally, and it is strongly associated with obesity. To combat obesity, artificial sweeteners are often used to replace natural sugars, and sucralose is one of the most ...
Hung-Tsung Wu, Ching-Han Lin, Hsiu-Ling Pai, Yi-Cheng Chen, Kai-Pi Cheng, Hsin-Yu Kuo, Hsin-Yu Kuo, Chung-Hao Li, Horng-Yih Ou, Horng-Yih Ou   +9 more
doaj   +2 more sources

Sucralose Promotes Benzo(a)Pyrene-Induced Renal Toxicity in Mice by Regulating P-glycoprotein

Antioxidants
Background: Sucralose and benzo(a)pyrene (B[a]P) are widespread foodborne substances known to harm human health. However, the effects of their combined exposure on kidney function remain unclear.
Jun Hu, Ji Feng, Yan Bai, Zhi-Sheng Yao, Xiao-Yu Wu, Xin-Yu Hong, Guo-Dong Lu, Kun Xue   +7 more
doaj   +2 more sources

Low Dose of Sucralose Alter Gut Microbiome in Mice

Frontiers in Nutrition, 2022
Sucralose is a non-nutritive artificial sweetener (NNS) used in foods or beverages to control blood glucose levels and body weight gain. The consumption of NNS has increased in recent years over the world, and many researches have indicated long-term ...
Zibin Zheng, Zibin Zheng, Yingping Xiao, Lingyan Ma, Wentao Lyu, Hao Peng, Hao Peng, Xiaorong Wang, Ying Ren, Jinjun Li   +9 more
doaj   +2 more sources

Sucralose Targets the Insulin Signaling Pathway in the SH-SY5Y Neuroblastoma Cell Line

Metabolites, 2023
Sucralose is widely used as a non-nutritive sweetener (NNS). However, in order to justify its use as a non-nutritive food additive, sucralose would have to be metabolically neutral.
Marina Čović, Milorad Zjalić, Lovro Mihajlović, Marianna Pap, Jasenka Wagner, Dario Mandić, Željko Debeljak, Marija Heffer   +7 more
doaj   +2 more sources

Advancements and Challenges in Sucralose Determination: A Comparative Review of Chromatographic, Electrochemical, and Spectrophotometric Methods

Foods
This review presents an in-depth analysis of the latest methods used for the determination of sucralose (E955), focusing on research conducted over the past 10 years.
Volodymyr V. Tkach, Tetiana V. Morozova, Isabel O’Neill de Mascarenhas Gaivão, Yana G. Ivanushko, José Inácio Ferrão da Paiva Martins, Ana Novo Barros   +5 more
doaj   +2 more sources

Sucralose Influences the Productive Performance, Carcass Traits, Blood Components, and Gut Microflora Using 16S rRNA Sequencing of Growing APRI-Line Rabbits

Animals
This study investigated how sucralose influenced rabbit intestine and caecal microbial activity, blood parameters, growth performance, carcass characteristics, and digestibility. In total, 160 5-week-old rabbits from the APRI line weighing 563.29 gm were
Hatem M. El-Tahan, Mohamad Elsayed Elmasry, H. A. Madian, Ahmad R. Alhimaidi, In Ho Kim, Jae Hong Park, Hossam M. El-Tahan   +6 more
doaj   +2 more sources

Sweet taste receptor serves to activate glucose- and leptin-responsive neurons in the hypothalamic arcuate nucleus and participates in glucose responsiveness. [PDF]

Frontiers in Neuroscience, 2016
The hypothalamic feeding center plays an important role in energy homeostasis. In the feeding center, whole-body energy signals including hormones and nutrients are sensed, processed, and integrated.
Daisuke Kohno, Miho Koike, Yuzo Ninomiya, Itaru Kojima, Tadahiro Kitamura, Toshihiko Yada   +5 more
doaj   +3 more sources