Results 161 to 170 of about 9,709 (198)

The non-nutritive sweetener sucralose increases β-arrestin signaling at the constitutively active orphan G protein-coupled receptor GPR52.

Canadian Journal of Physiology and Pharmacology, 2023
Non-nutritive sweeteners are popular food additives owing to their low caloric density and powerful sweetness relative to natural sugars. Their lack of metabolism contributes to evidence proclaiming their safety, yet several studies contravene this ...
Madeline E Power, N. Fernandez, Olaiya Peter Oni, Aditaya Kalia, J. L. Rourke   +4 more
semanticscholar   +1 more source

The metabolic fate of sucralose in rats

Food and Chemical Toxicology, 2000
The fate of sucralose was investigated in rats following single intravenous or oral doses of 2-1000mg/kg. Following intravenous administration (2-20mg/kg) approximately 80% of the dose was eliminated in urine with 9-16% in the faeces. In contrast, only about 5% of oral doses (10-1000mg/kg) was recovered in the urine, indicating that sucralose is poorly
J, Sims, A, Roberts, J W, Daniel, A G, Renwick   +3 more
openaire   +2 more sources

Hydrophobic interactions of sucralose with protein structures

Archives of Biochemistry and Biophysics, 2018
Sucralose is a commonly employed artificial sweetener that appears to destabilize protein native structures. This is in direct contrast to the bio-preservative nature of its natural counterpart, sucrose, which enhances the stability of biomolecules against environmental stress.
Nimesh Shukla, Enrico Pomarico, Cody J.S. Hecht, Erika A. Taylor, Majed Chergui, Christina M. Othon   +5 more
openaire   +2 more sources

Artificial sweeteners acesulfame and sucralose: from wastewater constituents to groundwater contaminants

Proceedings of the 37th International Congress on Process Industry
Acesulfame and sucralose are non-nutritive sweeteners widely used as sugar substitutes in food, beverages, and pharmaceuticals. As metabolically stable compounds, they are ubiquitous constituents of municipal wastewaters ultimately discharged into the ...
Eleonora Gvozdić
semanticscholar   +1 more source

Sucralose with Bifunctional Groups as a Functional Additive Enhancing Interfacial Stability of Zinc Metal Anode via Interfacial Molecular Chemistry Regulation

Journal of Materials Chemistry A
Recent years have witnessed renewed interest in aqueous zinc-ion batteries, but challenges persist due to the rapid capacity decay and irreversible cycling of zinc anodes, primarily stemming from uncontrolled dendritic...
Huan Liu, Zijun Xin, Bin Cao, Di Zhang, Jie Lu, Yiwen Zhang, Zhijing Xu, Hongjuan Lai, Zirong Guo, Mengjiao Du   +9 more
semanticscholar   +1 more source

Induction of the Interdigitated Gel Phase of Hydrated Dipalmitoylphosphatidylcholine Bilayers by the Artificial Sweetener Sucralose.

Journal of Physical Chemistry B
Recent research indicates that high doses of sucralose content can weaken the immune response in mice. To better understand the interaction between cell membranes and sucralose, we studied model biomembranes composed of dipalmitoylphosphatidylcholine ...
Emika Matsumoto, Michael Postrado, Hiroshi Takahashi   +2 more
semanticscholar   +1 more source

Acute and subchronic toxicity of sucralose

Food and Chemical Toxicology, 2000
The toxicity of sucralose has been evaluated in acute and subchronic toxicity studies. Acute oral toxicity studies in male and female mice and male rats documented no deaths or treatment-related signs at doses of 16g/kg for mice and 10g/kg for rats. Sucralose was administered to male and female rats for 4 and 8 weeks at dietary concentrations of 1.0, 2.
openaire   +2 more sources

Assessment of human abuse potential of an unflavored, sucralose-sweetened electronic cigarette in combustible cigarette smokers.

Experimental and clinical psychopharmacology
Despite the popularity of electronic cigarettes (ECIGs), limited research has examined the role of sweeteners, independent of other flavors, in shaping ECIG human abuse potential (HAP).
Sarah F Maloney, Cosima Hoetger, Rose S. Bono, Rebecca Lester Scholtes, Madison Combs, Nareg Karaoghlanian, T. Lipato, A. Breland, T. Eissenberg   +8 more
semanticscholar   +1 more source

An overview of the safety of sucralose

Regulatory Toxicology and Pharmacology, 2009
Sucralose is a non-nutritive sweetener used in a broad range of foods and beverages and is the non-nutritive sweetener in retail SPLENDA Sweetening Products, composed of sucralose and common food ingredients. A review of the extensive body of evidence that supports the safety of sucralose is provided. The results of an independent review of a new study
V Lee, Grotz, Ian C, Munro
openaire   +2 more sources

Popular Sweetner Sucralose as a Migraine Trigger

Headache: The Journal of Head and Face Pain, 2006
Sucralose (trichlorogalactosucrose, or better known as Splenda) is an artificial sweetener from native sucrose that was approved by the FDA on April 1, 1998 (April Fool's Day). This observation of a potential causal relationship between sucralose and migraines may be important for physicians to remember this can be a possible trigger during dietary ...
Rajendrakumar M, Patel, Rakesh, Sarma, Edwin, Grimsley   +2 more
openaire   +2 more sources