Results 171 to 180 of about 941,649 (339)
Circular RNA PTPN4 Contributes to Blood‐Brain Barrier Disruption during Early Epileptogenesis
Epileptic condition induces CircPTPN4 upregulation, which promotes ECE‐1 expression through competitive sequestration of miR‐145a‐5p. The elevated ECE‐1 catalyzes the ET‐1 production, leading to p38/MAPK pathway activation and subsequent downregulation of tight junction protein expression. This cascade results in increased BBB permeability and enhanced
Jiurong Yang +16 more
wiley +1 more source
Effects of adolescent sucrose overconsumption on serotonin and dopamine signalling and associated maladaptive effects in adulthood [PDF]
K. Matthews
openalex +1 more source
Acute brain injuries are characterized by extensive tissue damage, resulting in debilitating deficits in patients. Despite considerable progress, cell‐based approaches have yet to identify an ideal candidate. This long‐term study explores the use of an untested cell source – human enteric glia – and a non‐invasive administration route – intranasal ...
Nina Colitti +11 more
wiley +1 more source
Morphine activates the excitatory cingulate cortex–intermediate rostrocaudal division of zona incerta (Cg‐ZIm) pathway to drive hyperlocomotion in mice. Inhibiting the Cg‐ZIm pathway attenuates both acute and chronic morphine‐induced hyperlocomotion, while its activation mimics morphine's motor effects.
Chun‐Yue Li +13 more
wiley +1 more source
A critical role of <i>sux</i> cistron-mediated sucrose uptake for virulence of the rice blight pathogen <i>Xanthomonas oryzae</i> pv. <i>oryzae</i>. [PDF]
Zöllner NR +11 more
europepmc +1 more source
EIF1AX Nucleolar Condensates Enhance Susceptibilities for the Management of Endometrial Cancer
This schematic illustrates the mechanism of a senolytic strategy in endometrial cancer. EIF1AX facilitates the incorporation of DDX21 into nucleolar condensates, an event that suppresses rDNA transcription and induces cellular senescence. The compound 2,5‐MeC exploits this pathway by promoting EIF1AX nucleolar translocation and condensate formation ...
Chengyu Lv +8 more
wiley +1 more source
Advances in the Regulatory Mechanism of Enzymes Involved in Soluble Sugar Metabolism in Fruits. [PDF]
Meng Z +12 more
europepmc +1 more source

