Results 271 to 280 of about 1,032,066 (371)

Neonatal Sucrose and Internalizing Behaviors at 18 Months in Children Born Very Preterm.

open access: yesJAMA Netw Open
McLean MA   +11 more
europepmc   +1 more source

LncRNA‐MEG3 Regulates Muscle Mass and Metabolic Homeostasis by Facilitating SUZ12 Liquid–Liquid Phase Separation

open access: yesAdvanced Science, EarlyView.
This study has identified lncRNA‐MEG3 as a key regulator of muscle mass, promoting slow‐twitch muscle fibers and preventing muscle atrophy. By stabilizing the SUZ12/PRC2 complex through liquid–liquid phase separation (LLPS), lncRNA‐MEG3 influences mitochondrial function and lipid metabolism.
Yilong Yao   +15 more
wiley   +1 more source

Microglial MS4A4A Protects against Epileptic Seizures in Alzheimer's Disease

open access: yesAdvanced Science, EarlyView.
This study has unveiled significant new insights into the role of MS4A4A in Alzheimer's disease‐related epilepsy, highlighting its impact on microglial phagocytosis, mitochondrial metabolism, and cytoskeleton, and demonstrating its therapeutic potential in epilepsy management.
Meng Jiang   +10 more
wiley   +1 more source

Enhancing the Protein Stability of an Anticancer VHH‐Fc Heavy Chain Antibody through Computational Modeling and Variant Design

open access: yesAdvanced Science, EarlyView.
In this study, a computational pipeline is developed to systematically evaluate the conformational stability, disulfide bond reduction state, and aggregation and degradation tendencies of an anticancer VHH‐Fc fusion antibody. Based on the mechanistic insights, antibody variants with enhanced stability and increased yield are successfully designed. This
Yuan Fang   +10 more
wiley   +1 more source

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