Results 81 to 90 of about 19,076 (167)

Nosocomial Outbreak of Crimean-Congo Hemorrhagic Fever, Sudan

Emerging Infectious Diseases, 2010
To confirm the presence of Crimean-Congo hemorrhagic fever in Sudan, we tested serum of 8 patients with hemorrhagic fever in a rural hospital in 2008. Reverse transcription–PCR identified Crimean-Congo hemorrhagic fever virus. Its identification as group
Imadeldin E. Aradaib, Bobbie R. Erickson, Mubarak E. Mustafa, Marina L. Khristova, Nageeb S. Saeed, Rehab M. Elageb, Stuart T. Nichol   +6 more
doaj   +1 more source

Rational design of next-generation filovirus vaccines combining glycoprotein stabilization and nanoparticle display with glycan modification

Nature Communications
Filoviruses pose a significant threat to human health due to frequent outbreaks and high mortality. Although two vector-based vaccines are available for Ebola virus, a broadly protective filovirus vaccine remains elusive.
Yi-Zong Lee, Yi-Nan Zhang, Maddy L. Newby, Garrett Ward, Keegan Braz Gomes, Sarah Auclair, Connor DesRoberts, Joel D. Allen, Andrew B. Ward, Robyn L. Stanfield, Linling He, Max Crispin, Ian A. Wilson, Jiang Zhu   +13 more
doaj   +1 more source

Post-exposure immunotherapy for two ebolaviruses and Marburg virus in nonhuman primates

Nature Communications, 2019
Current experimental monoclonal antibodies (mAbs) for Ebola virus (EBOV) post-exposure immunotherapy are ineffective against Sudan (SUDV) or Marburg virus (MARV).
Jennifer M. Brannan, Shihua He, Katie A. Howell, Laura I. Prugar, Wenjun Zhu, Hong Vu, Sergey Shulenin, Shweta Kailasan, Henna Raina, Gary Wong, Md Niaz Rahim, Logan Banadyga, Kevin Tierney, Xuelian Zhao, Yuxing Li, Frederick W. Holtsberg, John M. Dye, Xiangguo Qiu, M. Javad Aman   +18 more
doaj   +1 more source

Potent immunogenicity and protective efficacy of a multi-pathogen vaccination targeting Ebola, Sudan, Marburg and Lassa viruse.

PLoS Pathogens
Viral haemorrhagic fevers (VHF) pose a significant threat to human health. In recent years, VHF outbreaks caused by Ebola, Marburg and Lassa viruses have caused substantial morbidity and mortality in West and Central Africa.
Amy Flaxman, Sarah Sebastian, Sofia Appelberg, Kuan M Cha, Marta Ulaszewska, Jyothi Purushotham, Ciaran Gilbride, Hannah Sharpe, Alexandra J Spencer, Sagida Bibi, Daniel Wright, Isabel Schmidt, Stuart Dowall, Linda Easterbrook, Stephen Findlay-Wilson, Sarah Gilbert, Ali Mirazimi, Teresa Lambe   +17 more
doaj   +1 more source

Resurgence of Ebola in Uganda: Response Strategies, Lessons Learned, and Future Directions

Health Science Reports
Introduction The recent resurgence of Ebola virus disease (EVD), specifically the Sudan virus strain, in Uganda highlights the ongoing threat of emerging infectious diseases.
Majani Edward, Sylivester Muhigi, Joan Mundua, Ally Ally   +3 more
doaj   +1 more source

Abstracts From AIDS 2026, the 26th International AIDS Conference, 26 – 31 July 2026 Rio de Janeiro, Brazil & virtual

Journal of the International AIDS Society, Volume 29, Issue S4, July 2026.
wiley   +1 more source

In silico exploration of deep-sea fungal metabolites as inhibitor of Ebola and Marburg VP35 and VP40.

PLoS ONE
VP30 and VP40 proteins of Ebola and Marburg viruses have been recognized as potential targets for antiviral drug development due to their essential roles in the viral lifecycle.
Abdullah R Alanzi, Mohammed F Alajmi, Mohammed S Al-Dosari, Mohammad K Parvez, Moneerah J Alqahtani   +4 more
doaj   +1 more source

Estimates of Serial Interval and Reproduction Number of Sudan Virus, Uganda, August-November 2022. [PDF]

Emerg Infect Dis, 2023
Marziano V, Guzzetta G, Longini I, Merler S.   +3 more
europepmc   +1 more source

The rVSV-EBOV vaccine provides limited cross-protection against Sudan virus in guinea pigs. [PDF]

NPJ Vaccines, 2023
Cao W, He S, Liu G, Schulz H, Emeterio K, Chan M, Tierney K, Azaransky K, Soule G, Tailor N, Salawudeen A, Nichols R, Fusco J, Safronetz D, Banadyga L.   +14 more
europepmc   +1 more source

Species-specific immunogenicity and protective efficacy of a vesicular stomatitis virus-based Sudan virus vaccine: a challenge study in macaques. [PDF]

Lancet Microbe, 2023
Marzi A, Fletcher P, Feldmann F, Saturday G, Hanley PW, Feldmann H.   +5 more
europepmc   +1 more source