Results 81 to 90 of about 2,407,462 (283)

Calcium‐sensing receptor induces the apoptosis of chondrocytes in cooperation with phosphate transporter

open access: yesFEBS Open Bio, EarlyView.
Excess Ca2+ ions activate the Calcium‐Sensing Receptor (CaSR), which subsequently drives the uptake of excess inorganic phosphate (Pi) via the Pi transporter (Pit−1) in chondrocytes. This mechanism causes a toxic increase in intracellular Pi concentration, ultimately leading to chondrocyte apoptosis and pathological mineralization. Excess extracellular
Sachie Nakatani   +7 more
wiley   +1 more source

”Whatever Does Not Kill Me Makes Me Stronger”: A Sociological Analysis of Uses of the Concept of Resilience. The Case of Boris Cyrulnik’s Self-Help Books Readers

open access: yesSwiss Journal of Sociology, 2019
This article offers a social science analysis of the resilience concept’s success and common sense uses. Based on a sample of letters from the readers of the French author Boris Cyrulnik’s self-help best-sellers, the article first depicts the ...
Marquis Nicolas
doaj   +1 more source

John Paul II’s Theology of the Suffering Body

open access: yesThe Person and the Challenges. The Journal of Theology, Education, Canon Law and Social Studies Inspired by Pope John Paul II, 2019
This article evaluates the experience of suffering and its redemptive value in the light of St. John Paul II’s Theology of the Body. It begins by exploring how man was created in “the beginning,” before the experience of evil and sin.
Zachary Swantek
doaj   +1 more source

Enough Suffering: Thoughts on Suffering and Virtue [PDF]

open access: yesThe Journal of Value Inquiry, 2021
Coplan, Amy, Battaly, Heather
openaire   +2 more sources

Aquinas’ De malo and the Ostensibly Problematic Status of Natural Evil as Privation [PDF]

open access: yes, 2018
Arguments concerning the nature of natural evil vary in their conclusions depending on the particular approach with which they commence inquiry; one of the most contested conclusions regards evil as privation, sourcing its justification primarily from ...
Pertierra, Iñaki Xavier Larrauri
core   +1 more source

The photoswitchable cannabinoid azo‐HU308 enables optical control of Ca2+ dynamics in INS‐1 β‐cells via off‐target effects on TRPC channels

open access: yesFEBS Open Bio, EarlyView.
Light activation of the photoswitchable cannabinoid ligand azo‐HU308 triggers Ca2+ influx in pancreatic β‐cells through TRPC channels, independent of CB2 cannabinoid receptors. This reveals a non‐GPCR pathway for cannabinoid modulation of β‐cell Ca2+ dynamics and establishes azo‐HU308 as an optical tool to study cannabinoid signaling through TRP ...
Alexander E. G. Viray, James A. Frank
wiley   +1 more source

Dysthanasia [PDF]

open access: yesScripta Medica
Dysthanasia in medicine is the artificial prolongation and delay of death in a terminal patient, using all available means. With the advancement of sophisticated medical technologies and care, the patient can be kept alive as long as possible in the ...
Greš Alen   +2 more
doaj   +1 more source

On Job: God-Talk and the Suffering of the Innocent [PDF]

open access: yes, 1987
Reviewed Book: Gutiérrez, Gustavo. On Job: God-TaLuke and the Suffering of the Innocent.
Teigen, Ragnar C.
core   +1 more source

Down‐regulation of Shh in the hair follicles of mice during chemotherapy‐induced hair loss is mediated by the JAK/STAT1 signaling pathway

open access: yesFEBS Open Bio, EarlyView.
We found that during chemotherapy‐induced alopecia (CIA), Sonic hedgehog (Shh) expression significantly decreased in hair follicle Shh+ cells, whereas the Janus‐activated kinase/signal transducer and activator of transcription 1 (JAK/STAT1) signaling pathway was markedly activated.
Ruifang Fan   +6 more
wiley   +1 more source

Icons of Just Is: Justice, Suffering, and the Artwork of Samuel Bak

open access: yesReligions, 2017
This paper examines select paintings by Holocaust survivor and painter Samuel Bak from his recent Just Is series. The essay explores ways Bak’s art bears witness to suffering.
Gary A. Phillips
doaj   +1 more source

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