Results 51 to 60 of about 845,542 (252)

Contour regression: A general approach to dimension reduction [PDF]

, 2005
We propose a novel approach to sufficient dimension reduction in regression, based on estimating contour directions of small variation in the response. These directions span the orthogonal complement of the minimal space relevant for the regression and ...
Chiaromonte, Francesca, Li, Bing, Zha, Hongyuan   +2 more
core   +1 more source

Likelihood-Based Sufficient Dimension Reduction

Journal of the American Statistical Association, 2009
We obtain the maximum likelihood estimator of the central subspace under conditional normality of the predictors given the response. Analytically and in simulations we found that our new estimator can preform much better than sliced inverse regression, sliced average variance estimation and directional regression, and that it seems quite robust to ...
Cook, R. Dennis, Forzani, Liliana
openaire   +4 more sources

Impact of sufficient dimension reduction in nonparametric estimation of causal effect

Statistical Theory and Related Fields, 2018
We consider the estimation of causal treatment effect using nonparametric regression or inverse propensity weighting together with sufficient dimension reduction for searching low-dimensional covariate subsets.
Ying Zhang, Jun Shao, Menggang Yu, Lei Wang   +3 more
doaj   +1 more source

Sufficient Dimension Reduction for Interactions

, 2020
Dimension reduction lies at the heart of many statistical methods. In regression, dimension reduction has been linked to the notion of sufficiency whereby the relation of the response to a set of predictors is explained by a lower dimensional subspace in the predictor space.
Park, Hyung, Petkova, Eva, Tarpey, Thaddeus, Ogden, R. Todd   +3 more
openaire   +2 more sources

Multiple phenotype association tests based on sliced inverse regression

BMC Bioinformatics
Background Joint analysis of multiple phenotypes in studies of biological systems such as Genome-Wide Association Studies is critical to revealing the functional interactions between various traits and genetic variants, but growth of data in ...
Wenyuan Sun, Kyongson Jon, Wensheng Zhu, the Alzheimer’s Disease Neuroimaging Initiative   +3 more
doaj   +1 more source

Optimization of Multidimensional Energy Security: An Index Based Assessment

Energies, 2022
This study introduces Pakistan’s multidimensional energy security index (PMESI) and indices across dimensions from 1991 to 2020 through indicator optimization.
Fahad Bin Abdullah, Rizwan Iqbal, Sadique Ahmad, Mohammed A. El-Affendi, Pardeep Kumar   +4 more
doaj   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

FEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo, Catherine S. Palmer, Jacqueline M. Kimmey   +2 more
wiley   +1 more source

Yukawa Deflected Gauge Mediation in Four Dimensions [PDF]

, 2002
We construct a four dimensional realization of a higher dimensional model, Yukawa deflected gauge mediation, in which supersymmetry breaking is communicated to the visible sector through both gauge and Yukawa interactions.
A. Adams, A. de Gouvea, C. Csaki, C. Csaki, C. Csaki, C.T. Hill, C.T. Hill, D.E. Kaplan, E. Katz, E. Perazzi, G.F. Giudice, H.C. Cheng, H.C. Cheng, H.C. Cheng, H.C. Cheng, I. Rothstein, K. Agashe, K. Sfetsos, L. Alvarez-Gaumé, L. Randall, M. Alishahiha, M. Bander, M. Dine, M. Dine, M. Dine, M. Dine, M. Dine, N. Arkani-Hamed, N. Arkani-Hamed, P.H. Chankowski, S. Dimopoulos, T. Han, W. Skiba, Z. Chacko, Z. Chacko, Z. Chacko   +35 more
core   +3 more sources

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source