Results 81 to 90 of about 846,250 (270)

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

A hybrid heteroclinic cycle

Examples and Counterexamples, 2022
Using a vector field in R4, we provide an example of a robust heteroclinic cycle between two equilibria that displays a mix of features exhibited by well-known types of low-dimensional heteroclinic structures, including simple, quasi-simple and pseudo ...
Sofia B.S.D. Castro, Alexander Lohse
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Plugin procedure in segmentation and application to hyperspectral image segmentation

, 2010
In this article we give our contribution to the problem of segmentation with plug-in procedures. We give general sufficient conditions under which plug in procedure are efficient. We also give an algorithm that satisfy these conditions.
Girard, R.
core   +3 more sources

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

The Alternating Direction Method of Multipliers for Sufficient Dimension Reduction

Journal of Mathematics
The minimum average variance estimation (MAVE) method has proven to be an effective approach to sufficient dimension reduction. In this study, we apply the computationally efficient optimization algorithm named alternating direction method of multipliers
Sheng Ma, Qin Jiang, Zaiqiang Ku
doaj   +1 more source

Impact of informational dimension and information on the operation cost [PDF]

Војно дело, 2014
Despite the disappearance of the bipolar world, the mankind has not yet become free from challenges, risks and threats to peace and security. Armed conflicts have remained a part of reality, and new security challenges, risks and threats have emerged ...
Miladinović Mića, Šipka Branko
doaj   +1 more source

Dynamic Partial Sufficient Dimension Reduction

, 2019
Sufficient dimension reduction aims for reduction of dimensionality of a regression without loss of information by replacing the original predictor with its lower-dimensional subspace. Partial (sufficient) dimension reduction arises when the predictors naturally fall into two sets, X and W, and we seek dimension reduction on X alone while considering ...
Li, Lu, Tan, Kai, Wen, Xuerong Meggie, Yu, Zhou   +3 more
openaire   +2 more sources

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Sufficient Dimension Reduction for Classification

Statistica Sinica
We propose a new sufficient dimension reduction approach designed deliberately for high-dimensional classification. This novel method is named maximal mean variance (MMV), inspired by the mean variance index first proposed by Cui, Li and Zhong (2015), which measures the dependence between a categorical random variable with multiple classes and a ...
Chen, Xin, Wu, Jingjing, Yao, Zhigang, Zhang, Jia   +3 more
openaire   +2 more sources