What we need to know and do on sugammadex usage in pregnant and lactating women and those on hormonal contraceptives [PDF]
Anesthesia and Pain Medicine, 2023 Sugammadex is a chemically modified γ-cyclodextrin that is used as a selective reversal agent for steroidal neuromuscular blockade. The use of sugammadex has greatly increased globally; however, little is known about its potential adverse effects in ...
Wangseok Do, Ah-Reum Cho
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Sugammadex for reversal of neuromuscular blockade: a retrospective analysis of clinical outcomes and cost-effectiveness in a single center [PDF]
ClinicoEconomics and Outcomes Research, 2016 Michele Carron, Fabio Baratto, Francesco Zarantonello, Carlo Ori Department of Medicine, Anesthesiology and Intensive Care, University of Padova, Padova, Italy Objective: The aim of the study is to evaluate the clinical and economic impact of introducing
Carron M +3 more
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Frontiers in Pharmacology, 2023 Background: Sugammadex is known to reverse neuromuscular blockade induced by non-depolarizing agents. In children, the recommended dose for reversal of moderate neuromuscular blockade is 2 mg/kg.
Sang-Hwan Ji +17 more
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Sugammadex, a neuromuscular blockade reversal agent, causes neuronal apoptosis in primary cultures. [PDF]
, 2013 Sugammadex, a γ-cyclodextrin that encapsulates selectively steroidal neuromuscular blocking agents, such as rocuronium or vecuronium, has changed the face of clinical neuromuscular pharmacology.
Aguirre Rueda, Diana +10 more
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Prediction of Optimal Reversal Dose of Sugammadex after Rocuronium Administration in Adult Surgical Patients [PDF]
Anesthesiology Research and Practice, 2014 The objective of this study was to determine the point after sugammadex administration at which sufficient or insufficient dose could be determined, using first twitch height of train-of-four (T1 height) or train-of-four ratio (TOFR) as indicators ...
Shigeaki Otomo +6 more
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Scientific Reports, 2023 Sugammadex reverses neuromuscular blockade by encapsulating steroidal neuromuscular blockers; therefore, it does not pharmacologically affect sedation levels.
Jeayoun Kim +6 more
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Effects of sugammadex on coagulation: a systematic review and meta-analysis [PDF]
BMC AnesthesiologyBackground Sugammadex, an innovative agent that rapidly and completely reverses rocuronium-induced neuromuscular blockade, may prolong coagulation time and influence postoperative bleeding.
Yu-Hsun Tsai +2 more
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Sugammadex-induced anaphylactic reaction: A systematic review
Journal of Anaesthesiology Clinical Pharmacology, 2022 Perioperative anaphylaxis is a rare, but life-threatening hypersensitivity reaction for patients undergoing surgical procedures. Sugammadex is a relatively new drug used to reverse the neuromuscular blockade of specific anesthetics in surgery.
Fatih Zecic +4 more
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Use and Outcomes of Sugammadex for Neurological Examination after Neuromuscular Blockade in the Emergency Department. [PDF]
West J Emerg MedIntroduction: Non-depolarizing agents such as rocuronium and vecuronium are frequently used in the emergency department (ED) to facilitate intubation but may lead to delay in neurologic examination and intervention.
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Postoperative mortality in patients with end-stage renal disease according to the use of sugammadex: a single-center retrospective propensity score matched study [PDF]
Anesthesia and Pain Medicine, 2022 Background Clearance of the sugammadex-rocuronium complex is limited to renal excretion. There are restrictions on the use of sugammadex in patients with severe renal impairment.
Sanghoon Song +10 more
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