Results 201 to 210 of about 575,880 (285)

Complete Pathway Refactoring and Combinatorial Biosynthesis of Anthracyclines for Modulation of Histone Eviction and DNA Damage Bioactivities

Angewandte Chemie, EarlyView.
A synthetic biology platform was established for the complete refactoring of complex anthracycline biosynthetic pathways in Streptomyces coelicolor using standardized, chemically synthetic DNA parts. This modular construction enabled streamlined combinatorial biosynthesis, yielding novel analogs that decouple DNA damage from chromatin damage (histone ...
Rongbin Wang, Heli Tirkkonen, Sabina Y. van der Zanden, Larissa Ponomareva, Isaline Fagon, Leslie Fève, Kendall Paige, Courtney L. Brown, Nora Schwartz, Jacob Hecht, Jennifer Nguyen, Jon S. Thorson, Jacques Neefjes, S. Eric Nybo, Khaled A. Shaaban, Mikko Metsä‐Ketelä   +15 more
wiley   +2 more sources

The intensity and spatial dispersion of within‐plant herbivory drive trait‐specific resistance and tolerance in wild cotton

American Journal of Botany, EarlyView.
Abstract Premise Herbivory induces complex plant defensive responses that may vary depending on the amount and spatial dispersion of damage on the plant; however, of the two variables, damage dispersion has received much less attention. To address this gap, we studied wild cotton (Gossypium hirsutum) defensive responses to different herbivory amounts ...
Víctor Hugo Ramírez‐Delgado, Yeyson Briones‐May, Juan Sánchez‐Durán, Lucía Martín‐Cacheda, Xoaquín Moreira, Ted C. J. Turlings, Luis Abdala‐Roberts   +6 more
wiley   +1 more source

Molecular Details of RNA Interactions With FUS Condensates Altering Assembly, Dynamics, and Aggregation

Angewandte Chemie, EarlyView.
Using NMR and molecular simulations, we map how RNA engages FUS LC‐RGG1 within condensates through electrostatic, π‐stacking, and polar contacts. These multivalent RNA contacts help stabilize RNA within FUS condensates while also reshaping condensate composition and dynamics.
Tongyin Zheng, Kandarp A. Sojitra, Samara Cummings, Qizan Chen, Priyesh Mohanty, Jeetain Mittal, Nicolas L. Fawzi   +6 more
wiley   +2 more sources

The potato sugar transporter SWEET1g affects apoplasmic sugar ratio and phloem-mobile tuber- and flower-inducing signals. [PDF]

Plant Physiol
Lauschke A, Maibaum L, Engel M, Eisengräber L, Bayer S, Hackel A, Kühn C.   +6 more
europepmc   +1 more source

The EXPLAIN Study: Exploring Arthrogryposis Multiplex Congenita in Adults in Norway — A Description of Demographic, Medical, and Neurological Findings

American Journal of Medical Genetics Part C: Seminars in Medical Genetics, EarlyView.
ABSTRACT Arthrogryposis Multiplex Congenita (AMC) encompasses several hundred conditions with diverse genetic, pathophysiological, and clinical origins. The overarching EXPLAIN study explores underlying causes and implications of AMC and represents the largest clinical cohort of adults with AMC reported to date.
My Vuong Hermansen, Kristin Ørstavik, Unni Steen, Mathias Toft, Cathrine Brunborg, Lena Lande Wekre   +5 more
wiley   +1 more source

Ag─S Sites Steer Furfural Electroreduction to Furfuryl Alcohol

Angewandte Chemie, EarlyView.
A simple sulfide incorporation strategy turns silver into a highly active and selective catalyst for furfural electroreduction to furfuryl alcohol. Experiments combined with density functional theory reveal how isolated S sites promote hydrogenation while suppressing hydrofuroin coupling, enabling selective biomass upgrading.
Haibin Ma, Jordi Morales‐Vidal, George Teo, Muhammad S. Naeem, Terence Jing Cong Tan, Núria López, Boon Siang Yeo   +6 more
wiley   +2 more sources

Genome-Wide Identification and Expression Pattern of Sugar Transporter Genes in the Brown Planthopper, Nilaparvata lugens (Stål). [PDF]

Insects
Shangguan X, Yang X, Wang S, Geng L, Wang L, Zhao M, Cao H, Zhang Y, Li X, Yang M, Xu K, Zheng X.   +11 more
europepmc   +1 more source

Stabilizing Functional Nucleic Acids for Real‐Sample Diagnostics

Angewandte Chemie, EarlyView.
Functional nucleic acids enable programmable real‐sample diagnostics, but often lose function in complex biological matrices. This review highlights four stabilization levers—chemical, topological, architectural, and microenvironment/interface engineering—that preserve aptamer and DNAzyme performance in saliva, serum, urine, and stool, reframing ...
Soyeon Lee, Letizia Dondi, Amal Mathai, Connor Nurmi, Yingfu Li   +4 more
wiley   +2 more sources

Whole-Genome Resequencing Identifies SNPs in Sucrose Synthase and Sugar Transporter Genes Associated with Sweetness in Coconut. [PDF]

Plants (Basel)
Khongmaluan M, Aesomnuk W, Dumhai R, Pitaloka MK, Xiao Y, Xia R, Kraithong T, Phonsatta N, Panya A, Ruanjaichon V, Wanchana S, Arikit S.   +11 more
europepmc   +1 more source

Intermolecular Carbon–Carbon Naphthalene Coupling Involves a Radical Mechanism Driven by Cytochrome P450 in Alternaria alternata

Angewandte Chemie, EarlyView.
1,8‐DHN is an important intermediate to form complex aromatic ring systems. Phenol‐coupling reactions are important for the dimerization of two molecules. Here, we show that a fungal cytochrome P450 enzyme catalyzes specific C─C bonds. ABSTRACT Dihydroxynaphthalene (DHN) derivatives are precursors of biologically important molecules, including melanin ...
Jia Gao, Leyao Chen, Karin Steffen, Henrik Schweder, Birgit Schreckenberger, Shu‐Ming Li, Ben Auxier, Antonis Rokas, Reinhard Fischer   +8 more
wiley   +2 more sources