Results 71 to 80 of about 1,019,815 (357)
Arthritis Care &Research, Accepted Article.Objective Somatic items used in depression assessments can potentially overlap with symptoms related to physical illness, including systemic sclerosis (SSc). No studies have looked at whether somatic depression items may be influenced by diffuse versus limited SSc disease subtypes, which are associated with varying degrees of symptom presentation.
Sophie Hu +109 more
wiley +1 more source
Advanced Science, EarlyView.Using iPSC‐derived motoneurons and postmortem tissue from FUS‐ALS patients, it is demonstrated that increased mitochondrial transcription leads to elevated cytosolic double‐stranded RNA (dsRNA) levels. This aberrant accumulation activates a RIG‐I–dependent innate immune response leading to neurodegeneration, which is amenable for FDA‐ and EMA‐approved ...
Marcel Naumann +26 more
wiley +1 more source
A suicide prevention initiative at a jumping site: A mixed-methods evaluation
EClinicalMedicine, 2020 Background: Gap Park in Sydney, Australia has historically been recognised as a suicide jumping site. In 2010–2011 the Gap Park Masterplan initiative implemented a series of suicide prevention measures.
Victoria Ross, Yu Wen Koo, Kairi Kõlves
doaj +1 more source
Multi‐Site Transfer Classification of Major Depressive Disorder: An fMRI Study in 3335 Subjects
Advanced Science, EarlyView.The study proposes graph convolution network with sparse pooling to learn the hierarchical features of brain graph for MDD classification. Experiment is done on multi‐site fMRI samples (3335 subjects, the largest functional dataset of MDD to date) and transfer learning is applied, achieving an average accuracy of 70.14%.
Jianpo Su +14 more
wiley +1 more source
Advanced Science, EarlyView.The preferred derivative JX3212 demonstrates strong inhibitory activity against Kir4.1 with favorable druggability and shows significant antidepressant efficacy in vivo. Abstract Major depressive disorder is a serious psychiatric disorder for which novel and fast‐acting antidepressants are required.
Sisi Wang +15 more
wiley +1 more source
Forecasting call and chat volumes at online helplines for mental health
BMC Public Health, 2023 Background Each year, many help seekers in need contact health helplines for mental support. It is crucial that they receive support immediately, and that waiting times are minimal. In order to minimize delay, helplines must have adequate staffing levels,
Tim Rens de Boer +4 more
doaj +1 more source
Advanced Science, EarlyView.BioE is a new diiron oxygenase that catalyzes the conversion of long‐chain acyl groups into pimeloyl thioester, initiating biotin synthesis. The overexpression of EmBioE disrupts lipid metabolic homeostasis, requiring repressor BioL to maintain a balance between long‐chain fatty acids and biotin synthesis.
Meng Zhang +9 more
wiley +1 more source
Psychiatric diagnosis in attempted suicide [PDF]
, 2006 This is a retrospective study which assesses the various socio-demographic correlates, the methods adopted to commit suicide and the psychiatric disorders in patients attempting suicide.
Baby, Sanjush, KF, Yesudas, P, Manju
core
Astrocytic PERK Deficiency Drives Prefrontal Circuit Dysfunction and Depressive‐Like Behaviors
Advanced Science, EarlyView.Chen et al. show that the endoplasmic reticulum (ER) stress sensor PERK is downregulated in prefrontal cortex (PFC) astrocytes in major depressive disorder and in chronic‐stress mouse models. In young mice, astrocyte‐specific PERK loss reduces the synaptogenic cue thrombospondin‐1 (TSP1), leading to synaptic and circuit deficits and depressive‐like ...
Kai Chen +8 more
wiley +1 more source