Results 91 to 100 of about 31,699 (207)

A Comprehensive Study to Determine the Residual Elimination Pattern of Major Metabolites of Amoxicillin–Sulbactam Hybrid Molecules in Rats by UPLC–MS/MS

Molecules
Amoxicillin and sulbactam are widely used in animal food compounding. Amoxicillin–sulbactam hybrid molecules are bicester compounds made by linking amoxicillin and sulbactam with methylene groups and have good application prospects. However, the residual
Feike Zhao, Xueyan Sun, Jian Li, Junyuan Du, Zhiyi Wu, Shujuan Liu, Liangzhu Chen, Binghu Fang   +7 more
doaj   +1 more source

Electrochemical sensor for the detection of serine β-lactamase catalytic activity

Chimica Techno Acta
A new approach is proposed based on the use of electrodes modified with carbon nanomaterials to determine enzymatic activity and screening for inhibitors of serine β-lactamases such as extended spectrum β-lactamases (ESBLs). These enzymes are responsible
Victoria V. Shumyantseva, Tatiana V. Bulko, Galina V. Presnova, Vitaly G. Grigorenko, Maya Yu. Rubtsova   +4 more
doaj   +1 more source

Flexible Development Programs for Antibacterial Drugs to Address Unmet Medical Needs

Emerging Infectious Diseases
The US Food and Drug Administration recognizes the unmet medical need for antibacterial drugs to treat serious bacterial diseases caused by resistant pathogens for which effective therapies are limited or lacking.
Mayurika Ghosh, Dmitri Iarikov, Xiaojing (Karen) Qi, Daniel Rubin, Simone Shurland, Avery Goodwin, Xiaohui Wei, Dakshina Chilukuri, Owen McMaster, Terry Miller, Peter Kim, Adam Sherwat   +11 more
doaj   +1 more source

A Laboratory Protocol for Routine Therapeutic Drug Monitoring of Beta-Lactams Antimicrobials in Horses and Dogs

Antibiotics
Background: Although antibiotic resistance is a well-known issue in veterinary medicine, studies proposing real-time therapeutic monitoring (TDM) are lacking. The objective of the present study was to develop a simple and rapid protocol for the real-time
Anisa Bardhi, Aliai Lanci, Aurora Mannini, Carolina Castagnetti, Andrea Barbarossa   +4 more
doaj   +1 more source

Severe delayed coagulopathy caused by cefoperazone/sulbactam: A case report

This case report described a suspected severe coagulopathy attributed to cefoperazone/sulbactam, and this adverse reaction might be associated with the inhibition of the vitamin K cycle by cefoperazone/sulbactam, leading to vitamin K deficiency within ...
Jie Min, Lei Yu, Yixuan Wang, Siqin Sun, Zhidan Wang   +4 more
core   +1 more source

Adverse Event Signals Associated with Beta-Lactamase Inhibitors: Disproportionality Analysis of USFDA Adverse Event Reporting System

Journal of Xenobiotics
Background: Beta-lactamase inhibitors (BLIs) are widely used with beta-lactam antibiotics to combat resistant infections, yet their safety profiles, especially for newer agents, remain underexplored.
Kannan Sridharan, Gowri Sivaramakrishnan
doaj   +1 more source

Postβ-Lactamase-Inhibiting Effect of Sulbactam in Combination with Ceftriaxone on Extended-Spectrum-β-Lactamase-Producing Escherichia coli

Antibiotics
Background/Objectives: Extended-spectrum β-lactamase (ESBL)-producing Escherichia coli poses a significant global health challenge, as it leads to antimicrobial treatment failure and is associated with elevated mortality rates.
Ru Wang, Kun Mi, Aihua Lu, Chengyang Zhang, Lei Sun, Yuxiang Chen, Yuanhu Pan, Yanfei Tao, Lingli Huang   +8 more
doaj   +1 more source

FIC values of Ampicillin/sulbactam plus Cefepime combination.

, 2017
FIC values of Ampicillin/sulbactam plus Cefepime combination.
Mona M. Abdelkader (3753058), Mohammad M. Aboulwafa (3753052), Marwa A. El-Ashry (3753055), Khaled M. Aboshanab (3753061)   +3 more
core   +1 more source

In vitro activity of sulbactam in combination with other antimicrobial agents against extensively drug-resistant Acinetobacter baumannii

Microbiology Spectrum
Extensively drug-resistant (XDR) Acinetobacter baumannii infection has significant challenges due to limited treatment options. Although sulbactam (SUL) shows in vitro effectiveness against XDR A. baumannii, the efficacy of SUL-based combinations remains
Anupop Jitmuang, Surapee Tiengrim, Visanu Thamlikitkul, Pornpan Koomanachai   +3 more
doaj   +1 more source

FIC values of Ampicillin/sulbactam plus Levofloxacin combination.

, 2017
FIC values of Ampicillin/sulbactam plus Levofloxacin combination.
Mona M. Abdelkader (3753058), Mohammad M. Aboulwafa (3753052), Marwa A. El-Ashry (3753055), Khaled M. Aboshanab (3753061)   +3 more
core   +1 more source